<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05026486</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-04T15:58:05+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma</title>
            <author role="aut">
              <persName>
                <forename type="first">Aurore</forename>
                <surname>Perrot</surname>
              </persName>
              <idno type="halauthorid">726030-0</idno>
              <affiliation ref="#struct-1750863"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Lauwers-Cances</surname>
              </persName>
              <idno type="halauthorid">619643-0</idno>
              <affiliation ref="#struct-300075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elodie</forename>
                <surname>Tournay</surname>
              </persName>
              <idno type="halauthorid">1699947-0</idno>
              <affiliation ref="#struct-300075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cyrille</forename>
                <surname>Hulin</surname>
              </persName>
              <idno type="halauthorid">709484-0</idno>
              <affiliation ref="#struct-408207"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Lorraine</forename>
                <surname>Chretien</surname>
              </persName>
              <idno type="halauthorid">1009540-0</idno>
              <affiliation ref="#struct-300924"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Royer</surname>
              </persName>
              <idno type="halauthorid">139130-0</idno>
              <affiliation ref="#struct-300535"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mamoun</forename>
                <surname>Dib</surname>
              </persName>
              <idno type="halauthorid">738173-0</idno>
              <affiliation ref="#struct-151939"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Decaux</surname>
              </persName>
              <idno type="halauthorid">411652-0</idno>
              <affiliation ref="#struct-301327"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Jaccard</surname>
              </persName>
              <idno type="halauthorid">963042-0</idno>
              <affiliation ref="#struct-300906"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Belhadj</surname>
              </persName>
              <idno type="halauthorid">373329-0</idno>
              <affiliation ref="#struct-366262"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sabine</forename>
                <surname>Brechignac</surname>
              </persName>
              <idno type="halauthorid">1386814-0</idno>
              <affiliation ref="#struct-1007720"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Fontan</surname>
              </persName>
              <idno type="halauthorid">448184-0</idno>
              <affiliation ref="#struct-300165"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Voillat</surname>
              </persName>
              <idno type="halauthorid">440697-0</idno>
              <affiliation ref="#struct-408481"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Demarquette</surname>
              </persName>
              <idno type="halauthorid">860073-0</idno>
              <affiliation ref="#struct-1202364"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Collet</surname>
              </persName>
              <idno type="halauthorid">10214-0</idno>
              <affiliation ref="#struct-51335"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Rodon</surname>
              </persName>
              <idno type="halauthorid">440509-0</idno>
              <affiliation ref="#struct-1096008"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claudine</forename>
                <surname>Sohn</surname>
              </persName>
              <idno type="halauthorid">738178-0</idno>
              <affiliation ref="#struct-360891"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Lifermann</surname>
              </persName>
              <idno type="halauthorid">822331-0</idno>
              <affiliation ref="#struct-1075487"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frédérique</forename>
                <surname>Orsini-Piocelle</surname>
              </persName>
              <idno type="halauthorid">1183821-0</idno>
              <affiliation ref="#struct-489464"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valentine</forename>
                <surname>Richez</surname>
              </persName>
              <idno type="halauthorid">721716-0</idno>
              <affiliation ref="#struct-107940"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mohamad</forename>
                <surname>Mohty</surname>
              </persName>
              <idno type="halauthorid">461502-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Margaret</forename>
                <surname>Macro</surname>
              </persName>
              <idno type="halauthorid">859959-0</idno>
              <affiliation ref="#struct-300185"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stéphane</forename>
                <surname>Minvielle</surname>
              </persName>
              <idno type="halauthorid">456460-0</idno>
              <affiliation ref="#struct-474972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Moreau</surname>
              </persName>
              <email type="md5">5fa0a6a4ccebb4820bccd79e146b4877</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">759214</idno>
              <idno type="halauthorid" notation="string">228775-759214</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1780-8746</idno>
              <idno type="IDREF">https://www.idref.fr/113205252</idno>
              <affiliation ref="#struct-474972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <surname>Leleu</surname>
              </persName>
              <email type="md5">a1ce58cd3cec3f5c1a61e7618a6101aa</email>
              <email type="domain">chu-poitiers.fr</email>
              <idno type="idhal" notation="numeric">989084</idno>
              <idno type="halauthorid" notation="string">228777-989084</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9822-4170</idno>
              <idno type="IDREF">https://www.idref.fr/073451967</idno>
              <idno type="VIAF">https://viaf.org/viaf/189519842</idno>
              <idno type="ISNI">http://isni.org/isni/0000000139365662</idno>
              <affiliation ref="#struct-300170"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thierry</forename>
                <surname>Facon</surname>
              </persName>
              <idno type="halauthorid">481966-0</idno>
              <affiliation ref="#struct-425779"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Attal</surname>
              </persName>
              <idno type="halauthorid">308553-0</idno>
              <affiliation ref="#struct-450027"/>
              <affiliation ref="#struct-511697"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hervé</forename>
                <surname>Avet-Loiseau</surname>
              </persName>
              <idno type="halauthorid">583626-0</idno>
              <affiliation ref="#struct-511697"/>
              <affiliation ref="#struct-450027"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jill</forename>
                <surname>Corre</surname>
              </persName>
              <idno type="halauthorid">193266-0</idno>
              <affiliation ref="#struct-511697"/>
              <affiliation ref="#struct-450027"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Ludovic</forename>
                <surname>Martinet</surname>
              </persName>
              <email type="md5">5c8dcc3b2f4eb85908d1992b14ff039c</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>P01 CA155258/CA/NCI NIH HHS/United States</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-04-09 09:49:46</date>
              <date type="whenModified">2026-05-04 15:57:40</date>
              <date type="whenReleased">2025-04-09 09:49:46</date>
              <date type="whenProduced">2019-07-01</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804890"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="367274">
                <persName>
                  <forename>Ludovic</forename>
                  <surname>Martinet</surname>
                </persName>
                <email type="md5">5c8dcc3b2f4eb85908d1992b14ff039c</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05026486</idno>
            <idno type="halUri">https://hal.science/hal-05026486</idno>
            <idno type="halBibtex">perrot:hal-05026486</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Clinical Oncology&lt;/i&gt;, 2019, 37 (19), pp.1657-1665. &lt;a target="_blank" href="https://dx.doi.org/10.1200/JCO.18.00776"&gt;&amp;#x27E8;10.1200/JCO.18.00776&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Clinical Oncology, 2019, 37 (19), pp.1657-1665. &amp;#x27E8;10.1200/JCO.18.00776&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="CRCT">CRCT</idno>
            <idno type="stamp" n="CHU-POITIERS">CHU-POITIERS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">Supported by National Cancer Institute grants P01-155258 and P50-100707 (H.A.-L.) and the Cancer Pharmacology of Toulouse and Region rogram. The Centre de Recherches en Cancérologie de Toulouse Team13 is supported by la Fondation Association pour la Recherche sur la Cancer grant PGA1*20160203788.</note>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurore</forename>
                    <surname>Perrot</surname>
                  </persName>
                  <idno type="halauthorid">726030-0</idno>
                  <affiliation ref="#struct-1750863"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Lauwers-Cances</surname>
                  </persName>
                  <idno type="halauthorid">619643-0</idno>
                  <affiliation ref="#struct-300075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elodie</forename>
                    <surname>Tournay</surname>
                  </persName>
                  <idno type="halauthorid">1699947-0</idno>
                  <affiliation ref="#struct-300075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cyrille</forename>
                    <surname>Hulin</surname>
                  </persName>
                  <idno type="halauthorid">709484-0</idno>
                  <affiliation ref="#struct-408207"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Lorraine</forename>
                    <surname>Chretien</surname>
                  </persName>
                  <idno type="halauthorid">1009540-0</idno>
                  <affiliation ref="#struct-300924"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Royer</surname>
                  </persName>
                  <idno type="halauthorid">139130-0</idno>
                  <affiliation ref="#struct-300535"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mamoun</forename>
                    <surname>Dib</surname>
                  </persName>
                  <idno type="halauthorid">738173-0</idno>
                  <affiliation ref="#struct-151939"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Decaux</surname>
                  </persName>
                  <idno type="halauthorid">411652-0</idno>
                  <affiliation ref="#struct-301327"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Jaccard</surname>
                  </persName>
                  <idno type="halauthorid">963042-0</idno>
                  <affiliation ref="#struct-300906"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Belhadj</surname>
                  </persName>
                  <idno type="halauthorid">373329-0</idno>
                  <affiliation ref="#struct-366262"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sabine</forename>
                    <surname>Brechignac</surname>
                  </persName>
                  <idno type="halauthorid">1386814-0</idno>
                  <affiliation ref="#struct-1007720"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Fontan</surname>
                  </persName>
                  <idno type="halauthorid">448184-0</idno>
                  <affiliation ref="#struct-300165"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Voillat</surname>
                  </persName>
                  <idno type="halauthorid">440697-0</idno>
                  <affiliation ref="#struct-408481"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Demarquette</surname>
                  </persName>
                  <idno type="halauthorid">860073-0</idno>
                  <affiliation ref="#struct-1202364"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Collet</surname>
                  </persName>
                  <idno type="halauthorid">10214-0</idno>
                  <affiliation ref="#struct-51335"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Rodon</surname>
                  </persName>
                  <idno type="halauthorid">440509-0</idno>
                  <affiliation ref="#struct-1096008"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claudine</forename>
                    <surname>Sohn</surname>
                  </persName>
                  <idno type="halauthorid">738178-0</idno>
                  <affiliation ref="#struct-360891"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Lifermann</surname>
                  </persName>
                  <idno type="halauthorid">822331-0</idno>
                  <affiliation ref="#struct-1075487"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédérique</forename>
                    <surname>Orsini-Piocelle</surname>
                  </persName>
                  <idno type="halauthorid">1183821-0</idno>
                  <affiliation ref="#struct-489464"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valentine</forename>
                    <surname>Richez</surname>
                  </persName>
                  <idno type="halauthorid">721716-0</idno>
                  <affiliation ref="#struct-107940"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mohamad</forename>
                    <surname>Mohty</surname>
                  </persName>
                  <idno type="halauthorid">461502-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Margaret</forename>
                    <surname>Macro</surname>
                  </persName>
                  <idno type="halauthorid">859959-0</idno>
                  <affiliation ref="#struct-300185"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stéphane</forename>
                    <surname>Minvielle</surname>
                  </persName>
                  <idno type="halauthorid">456460-0</idno>
                  <affiliation ref="#struct-474972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Moreau</surname>
                  </persName>
                  <email type="md5">5fa0a6a4ccebb4820bccd79e146b4877</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">759214</idno>
                  <idno type="halauthorid" notation="string">228775-759214</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1780-8746</idno>
                  <idno type="IDREF">https://www.idref.fr/113205252</idno>
                  <affiliation ref="#struct-474972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>Leleu</surname>
                  </persName>
                  <email type="md5">a1ce58cd3cec3f5c1a61e7618a6101aa</email>
                  <email type="domain">chu-poitiers.fr</email>
                  <idno type="idhal" notation="numeric">989084</idno>
                  <idno type="halauthorid" notation="string">228777-989084</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9822-4170</idno>
                  <idno type="IDREF">https://www.idref.fr/073451967</idno>
                  <idno type="VIAF">https://viaf.org/viaf/189519842</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000139365662</idno>
                  <affiliation ref="#struct-300170"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thierry</forename>
                    <surname>Facon</surname>
                  </persName>
                  <idno type="halauthorid">481966-0</idno>
                  <affiliation ref="#struct-425779"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Attal</surname>
                  </persName>
                  <idno type="halauthorid">308553-0</idno>
                  <affiliation ref="#struct-450027"/>
                  <affiliation ref="#struct-511697"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hervé</forename>
                    <surname>Avet-Loiseau</surname>
                  </persName>
                  <idno type="halauthorid">583626-0</idno>
                  <affiliation ref="#struct-511697"/>
                  <affiliation ref="#struct-450027"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jill</forename>
                    <surname>Corre</surname>
                  </persName>
                  <idno type="halauthorid">193266-0</idno>
                  <affiliation ref="#struct-511697"/>
                  <affiliation ref="#struct-450027"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15236</idno>
                <idno type="issn">0732-183X</idno>
                <idno type="eissn">1527-7755</idno>
                <title level="j">Journal of Clinical Oncology</title>
                <imprint>
                  <publisher>American Society of Clinical Oncology</publisher>
                  <biblScope unit="volume">37</biblScope>
                  <biblScope unit="issue">19</biblScope>
                  <biblScope unit="pp">1657-1665</biblScope>
                  <date type="datePub">2019-07-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1200/JCO.18.00776</idno>
              <idno type="pubmed">31091136</idno>
              <idno type="pubmedcentral">PMC6804890</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Aged</classCode>
              <classCode scheme="mesh">Chromosomes, Human, Pair 21 / genetics</classCode>
              <classCode scheme="mesh">Translocation, Genetic</classCode>
              <classCode scheme="mesh">Trisomy</classCode>
              <classCode scheme="mesh">Chromosomes, Human, Pair 3 / genetics</classCode>
              <classCode scheme="mesh">Chromosomes, Human, Pair 5 / genetics</classCode>
              <classCode scheme="mesh">Cytogenetic Analysis / methods*</classCode>
              <classCode scheme="mesh">Disease-Free Survival</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Gene Deletion</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Multiple Myeloma / diagnosis</classCode>
              <classCode scheme="mesh">Multiple Myeloma / drug therapy*</classCode>
              <classCode scheme="mesh">Multiple Myeloma / mortality*</classCode>
              <classCode scheme="mesh">Multivariate Analysis</classCode>
              <classCode scheme="mesh">Prognosis*</classCode>
              <classCode scheme="mesh">Risk Assessment</classCode>
              <classCode scheme="mesh">Survival Analysis*</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>&lt;b&gt;Purpose:&lt;/b&gt; The wide heterogeneity in multiple myeloma (MM) outcome is driven mainly by cytogenetic abnormalities. The current definition of high-risk profile is restrictive and oversimplified. To adapt MM treatment to risk, we need to better define a cytogenetic risk classification. To address this issue, we simultaneously examined the prognostic impact of del(17p); t(4;14); del(1p32); 1q21 gain; and trisomies 3, 5, and 21 in a cohort of newly diagnosed patients with MM.&lt;b&gt;Methods: &lt;/b&gt;Data were obtained from 1,635 patients enrolled in four trials implemented by the Intergroupe Francophone du Myélome. The oldest collection of data were used for model development and internal validation. For external validation, one of the two independent data sets was used to assess the performance of the model in patients treated with more current regimens. Six cytogenetic abnormalities were identified as clinically relevant, and a prognostic index (PI) that was based on the parameter estimates of the multivariable Cox model was computed for all patients.&lt;b&gt;Results:&lt;/b&gt; In all data sets, a higher PI was consistently associated with a poor survival outcome. Dependent on the validation cohorts used, hazard ratios for patients in the high-risk category for death were between six and 15 times higher than those of patients in the low-risk category. Among patients with t(4;14) or del(17p), we observed a worse survival in those classified in the high-risk category than in those in the intermediate-risk category. The PI showed good performance for discriminating between patients who died and those who survived (Harrell's concordance index greater than 70%).&lt;b&gt;Conclusion:&lt;/b&gt; The cytogenetic PI improves the classification of newly diagnosed patients with MM in the high-risk group compared with current classifications. These findings may facilitate the development of risk-adapted treatment strategies.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-1750863" status="VALID">
          <idno type="ISNI">0000 0004 1765 1301</idno>
          <idno type="ROR">https://ror.org/016ncsr12</idno>
          <orgName>CHRU Nancy - Hôpitaux de Brabois</orgName>
          <date type="start">1973-01-01</date>
          <desc>
            <address>
              <addrLine>Rue du Morvan, 54500 Vandœuvre-lès-Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-nancy.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-408207" status="VALID">
          <idno type="ROR">https://ror.org/01hq89f96</idno>
          <orgName>CHU de Bordeaux Pellegrin [Bordeaux]</orgName>
          <desc>
            <address>
              <addrLine>Place Amélie Raba-Léon, 33000 Bordeaux</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300924" status="VALID">
          <idno type="ROR">https://ror.org/0377z4z10</idno>
          <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName>
          <orgName type="acronym">CHU Dijon</orgName>
          <desc>
            <address>
              <addrLine>14 rue Paul Gaffarel - 21079 Dijon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-dijon.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300535" status="VALID">
          <orgName>CHU Amiens-Picardie</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300906" status="VALID">
          <idno type="ROR">https://ror.org/01tc2d264</idno>
          <orgName>CHU Limoges</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-366262" status="VALID">
          <idno type="ROR">https://ror.org/04m61mj84</idno>
          <orgName>CHU Henri Mondor [Créteil]</orgName>
          <desc>
            <address>
              <addrLine>51, avenue du Maréchal de Lattre de Tassigny 94000 Créteil</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-103061" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1007720" status="VALID">
          <orgName>Groupe Hospitalier Hôpitaux Universitaires Paris Seine-Saint-Denis [Bobigny]</orgName>
          <orgName type="acronym">GH HUPSSD</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300165" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Besançon</orgName>
          <orgName type="acronym">CHRU Besançon</orgName>
          <desc>
            <address>
              <addrLine>3, boulevard A. Fleming - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-besancon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-408481" status="VALID">
          <orgName>Centre Hospitalier Chalon-sur-Saône William Morey</orgName>
          <orgName type="acronym">CH Chalon-sur-Saône</orgName>
          <desc>
            <address>
              <addrLine>4, rue Capitaine Drillien, 71321 Chalon-sur-Saône</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ch-chalon71.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1202364" status="VALID">
          <orgName>Hôpital Alexandra Lepève – Centre Hospitalier de Dunkerque</orgName>
          <orgName type="acronym">HAL – CH Dunkerque</orgName>
          <desc>
            <address>
              <addrLine>130, avenue Louis Herbeaux – CS 76 367 – 59385 Dunkerque Cedex 1 –  France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-dunkerque.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-51335" status="VALID">
          <idno type="IdRef">250789094</idno>
          <idno type="ROR">https://ror.org/04pn6vp43</idno>
          <orgName>Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]</orgName>
          <orgName type="acronym">CHU ST-E</orgName>
          <date type="start">1972-10-30</date>
          <desc>
            <address>
              <addrLine>42055 Saint Etienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1096008" status="VALID">
          <idno type="IdRef">034361197</idno>
          <orgName>CENTRE HOSPITALIER PÉRIGUEUX</orgName>
          <orgName type="acronym">CHP</orgName>
          <date type="start">1953-01-01</date>
          <desc>
            <address>
              <addrLine>80, avenue Georges Pompidou CS 6120524019 Périgueux cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-perigueux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-360891" status="VALID">
          <orgName>Centre Hospitalier Intercommunal de Toulon [La Seyne-sur-Mer]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-toulon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1075487" status="VALID">
          <idno type="ISNI">0000 0004 0634 7371</idno>
          <idno type="ROR">https://ror.org/03mg0pe18</idno>
          <orgName>Centre Hospitalier Dax - Côte d'Argent</orgName>
          <orgName type="acronym">CH Dax</orgName>
          <date type="start">1946-08-26</date>
          <desc>
            <address>
              <addrLine>1 Bd Yves du Manoir, 40100 Dax</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-dax.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-489464" status="VALID">
          <orgName>Centre Hospitalier d'Annecy Genevois</orgName>
          <desc>
            <address>
              <addrLine>Epagny Metz-Tessy, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-107940" status="VALID">
          <orgName>CHU Nice [Cimiez]</orgName>
          <desc>
            <address>
              <addrLine>4 avenue Reine Victoria 06003 Nice Cedex 1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-443277" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300185" status="VALID">
          <idno type="IdRef">031245382</idno>
          <idno type="ISNI">0000000404720160</idno>
          <idno type="ROR">https://ror.org/027arzy69</idno>
          <idno type="Wikidata">Q2945740</idno>
          <orgName>CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie</orgName>
          <orgName type="acronym">CHU Caen Normandie</orgName>
          <desc>
            <address>
              <addrLine>Avenue de la Côte de Nacre 14000 Caen</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-caen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300170" status="VALID">
          <idno type="ROR">https://ror.org/029s6hd13</idno>
          <orgName>Centre hospitalier universitaire de Poitiers = Poitiers University Hospital</orgName>
          <orgName type="acronym">CHU de Poitiers [La Milétrie]</orgName>
          <desc>
            <address>
              <addrLine>2 rue de la Milétrie – 86000 Poitiers – France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-poitiers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-450027" status="OLD">
          <idno type="ROR">https://ror.org/014hxhm89</idno>
          <orgName>Institut Universitaire du Cancer de Toulouse - Oncopole</orgName>
          <orgName type="acronym">IUCT Oncopole - UMR 1037</orgName>
          <desc>
            <address>
              <addrLine>Av. Irène Joliot-Curie 31100 Toulouse</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300075" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-511697" status="OLD">
          <idno type="IdRef">168095661</idno>
          <idno type="ISNI">0000000477733907</idno>
          <idno type="RNSR">201119444S</idno>
          <idno type="ROR">https://ror.org/003412r28</idno>
          <orgName>Centre de Recherches en Cancérologie de Toulouse</orgName>
          <orgName type="acronym">CRCT</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Centre de Recherches en Cancérologie de Toulouse2 Avenue Hubert Curien31037 Toulouse Cedex 1FRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.crct-inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="U1037" active="#struct-303623" type="direct"/>
            <relation name="UMR5071 / ERL5294" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-103061" status="VALID">
          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>
            <address>
              <addrLine>Créteil</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-443277" status="VALID">
          <orgName>Hôpital Cimiez [Nice]</orgName>
          <orgName type="acronym">CHU</orgName>
          <desc>
            <address>
              <addrLine>4, Avenue Reine Victoria - CS 91179 - 06003 Nice Cedex 1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>