Article Dans Une Revue AJP - Gastrointestinal and Liver Physiology Année : 2025

Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice

Résumé

Carbon monoxide (CO) produced by HO-1 upregulation in myenteric plexus is the main factor that abolishes the RMP gradient across colonic muscle wall causing the altered colonic motility seen in experimental ulcerative colitis (UC) mice. CO is a potential candidate as a therapeutic target for patients with UC who suffer from abnormal colonic motility.

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hal-05023467 , version 1 (07-04-2025)

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Mengchao Zhao, Yaru Lei, Mengyuan Wang, Yixin Chen, Shaozhang Hou, et al.. Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice. AJP - Gastrointestinal and Liver Physiology, 2025, 328 (3), pp.G311-G322. ⟨10.1152/ajpgi.00179.2023⟩. ⟨hal-05023467⟩
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