Poster De Conférence Année : 2025

CORALE project: Cumulative lifetime multi-exposures to ionizing radiation and other risk factors and associations with chronic diseases in the CONSTANCES cohort

Résumé

Introduction: The exposome is a concept encompassing the totality of human exposures from conception onwards. As a first application of this concept to ionising radiation (IR), the CORALE project aims to reconstruct lifetime IR exposures and analyze their associations with chronic diseases in the French general population CONSTANCES cohort. After estimating IR doses to six organs (brain, breast, thyroid, lungs, colon, prostate) from medical and environmental exposures since birth (1941 for the oldest), we focus on evaluating the combined effects of IR exposures and other factors such as smoking and alcohol, on the risks of cancers and cardiovascular diseases. Methods: A questionnaire was sent to 76,693 volunteers from the CONSTANCES cohort to collect data on several exposures to IR. Medical exposures were estimated by combining data from the questionnaire and the National Health Data System (SNDS), with a thorough review of the literature on French medical imaging practices. Environmental exposures related to geography were reconstructed using residential histories linked with radioactivity databases, while those based on lifestyle were estimated using exposure frequency and age. To assess the combined effects of these cumulated IR exposures treated as time-dependent variables, along with other risk factors, we will apply advanced survival statistical models, including multivariate regression and Bayesian approaches to identify specific exposure profiles.Results: We estimated lifetime exposure to IR for 30,964 respondents. The mean age at the end of follow-up in 2020 is 53, with a standard deviation of 13 years. We assessed doses, considering year and/or age at exposure and sex when applicable, from several medical procedures, including diagnostic nuclear medicine and CT scans, mammograms, panoramic dental radiographs and chest X-rays; and from environmental factors, including radon, telluric and cosmic radiation (ground-level cosmic rays and those received during air travel), fallout from Chernobyl accident and atmospheric nuclear tests, and seafood consumption. The average lifetime dose to the colon (often used to study association with solid cancers) is estimated to be 90 mSv. Between 5% and 95% of the population received dose below 27 mSv and 198 mSv, respectively. We identified that 37.4% of respondents consumed alcohol regularly, while 48.7% had a history of smoking. Discussion: Multi-exposure analyses are essential for understanding complex interactions between environmental and behavioral factors and their combined impact on health. We are developing models to explore the associations of these co-exposures with chronic disease incidence. Further extension to other risk factors, such as chemical, is underway. Keywords: CONSTANCES cohort, ionising radiation, multi-exposure, chronic diseases, survival analysis

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hal-05023424 , version 1 (07-04-2025)

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  • HAL Id : hal-05023424 , version 1

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Justine Sauce, Sophie Ancelet, Corinne Mandin, Philippe Renaud, Jean-Michel Métivier, et al.. CORALE project: Cumulative lifetime multi-exposures to ionizing radiation and other risk factors and associations with chronic diseases in the CONSTANCES cohort. 10th Survival Analysis for Junior Researchers (SAfJR) Conference, Mar 2025, Bonn, Germany. . ⟨hal-05023424⟩
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