Article Dans Une Revue RSC Advances Année : 2023

Convergent micro-wave assisted synthesis of quinazolinone and its precursor using the bio-sourced solvent pinane

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A general microwave synthesis of 4-oxo-3,4-dihydroquinazolin-2-yl propanoic acids and their diamide precursors from the corresponding substituted benzamide and succinic anhydride is described, using pinane as a sustainable solvent that favors the cyclization step. The conditions are some of the most simple and cost effective reported.

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hal-05023059 , version 1 (07-04-2025)

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Antoine Richieu, Philippe Bertrand. Convergent micro-wave assisted synthesis of quinazolinone and its precursor using the bio-sourced solvent pinane. RSC Advances, 2023, 13, pp.20646-20650. ⟨10.1039/d3ra03702a⟩. ⟨hal-05023059⟩
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