Article Dans Une Revue Veterinary Research Année : 2025

Longitudinal study of foot-and-mouth disease virus in Northern Nigeria: implications for the roles of small ruminants and environmental contamination in endemic settings

Simon Gubbins
  • Fonction : Auteur
Emma Brown
  • Fonction : Auteur
Yiltawe Wungak
  • Fonction : Auteur
Olumuyiwa Oyekan
  • Fonction : Auteur
Adeyinka J. Adedeji
  • Fonction : Auteur
Sandra I. Ijoma
  • Fonction : Auteur
Rebecca B. Atai
  • Fonction : Auteur
Moses O. Oguche
  • Fonction : Auteur
Mark Samson
  • Fonction : Auteur
Banenat B. Dogonyaro
  • Fonction : Auteur
Fabrizio Rosso
  • Fonction : Auteur
Hayley Hicks
  • Fonction : Auteur
Britta A. Wood
  • Fonction : Auteur
Jemma Wadsworth
  • Fonction : Auteur
Nick Knowles
  • Fonction : Auteur
Donald P. King
  • Fonction : Auteur
Anna B. Ludi
  • Fonction : Auteur
Claire Colenutt
  • Fonction : Auteur
Andrew E. Shaw
  • Fonction : Auteur
Georgina Limon
Connectez-vous pour contacter l'auteur
David O. Ehizibolo
  • Fonction : Auteur

Résumé

AbstractFoot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed ungulates. This study aimed to enhance our understanding of the role of small ruminants and environmental contamination in the epidemiology and endemicity of FMD. A longitudinal study was conducted between March 2021 and October 2021 in northern Nigeria, where monthly samples were collected from five households, one livestock market and one transhumance location in two local government areas (LGA) identified as being at high risk of FMD. Serum samples (n = 783), oral swabs (n = 424) and environmental swabs (n = 458) were collected and tested for the presence of foot-and-mouth disease virus (FMDV) RNA by rRT-PCR. Serum samples (n = 780) were also tested for the presence of antibodies against FMDV non-structural proteins. The proportion of FMDV RNA positive samples increased in all sample types collected in one LGA during the period when an FMD outbreak was reported in the same LGA. In contrast, sero-positive samples did not differ by month but differed between LGAs and amongst species. The force of infection estimated from age-seroprevalence data for each household was significantly lower in goats compared with both cattle or sheep. Five O/EA-3 topotype sequences were obtained from selected FMDV RNA positive samples; findings which support the use of environmental swabs to detect circulating FMDV strains in endemic settings. These results show oral and environmental swabs are suitable sampling methods for early detection at animal and herd level, respectively and provide insights on the role of small ruminants on FMD epidemiology.

Fichier principal
Vignette du fichier
13567_2025_Article_1502.pdf (2.87 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-05019847 , version 1 (03-04-2025)

Licence

Identifiants

Citer

Simon Gubbins, Emma Brown, Yiltawe Wungak, Olumuyiwa Oyekan, Adeyinka J. Adedeji, et al.. Longitudinal study of foot-and-mouth disease virus in Northern Nigeria: implications for the roles of small ruminants and environmental contamination in endemic settings. Veterinary Research, 2025, 56 (1), pp.76. ⟨10.1186/s13567-025-01502-2⟩. ⟨hal-05019847⟩

Collections

37 Consultations
77 Téléchargements

Altmetric

Partager

  • More