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            <title xml:lang="en">Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate</title>
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                <forename type="first">Andrea</forename>
                <surname>Largo-de la Torre</surname>
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                <forename type="first">Javier</forename>
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                <forename type="first">Luis Miguel</forename>
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            <idno type="halRefHtml">&lt;i&gt;Veterinary Research&lt;/i&gt;, 2025, 56 (1), pp.73. &lt;a target="_blank" href="https://dx.doi.org/10.1186/s13567-025-01507-x"&gt;&amp;#x27E8;10.1186/s13567-025-01507-x&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Andrea</forename>
                    <surname>Largo-de la Torre</surname>
                  </persName>
                  <idno type="halauthorid">3466464-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ignacio</forename>
                    <surname>Ferre</surname>
                  </persName>
                  <idno type="halauthorid">1010881-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Roberto</forename>
                    <surname>Sánchez-Sánchez</surname>
                  </persName>
                  <idno type="halauthorid">2001329-0</idno>
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                <author role="crp">
                  <persName>
                    <forename type="first">Javier</forename>
                    <surname>Regidor-Cerrillo</surname>
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                  <persName>
                    <forename type="first">Luis Miguel</forename>
                    <surname>Ortega-Mora</surname>
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                <idno type="eissn">1297-9716</idno>
                <title level="j">Veterinary Research</title>
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                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">56</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">73</biblScope>
                  <date type="datePub">2025-12</date>
                  <date type="dateEpub">2025</date>
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                <term xml:lang="en">field isolate</term>
                <term xml:lang="en">Type II and Type III</term>
                <term xml:lang="en">oocyst</term>
                <term xml:lang="en">mouse model</term>
                <term xml:lang="en">Toxoplasma gondii</term>
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              <p>AbstractType II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model based on an oral infection with oocysts from a recently obtained Type III isolate, TgShSp24, which exhibited remarkable morbidity and a distinct tissue distribution during chronic infection, differing from the recently obtained Type II isolate TgShSp1. This novel model aims to better mimic natural infection and provides a valuable tool for testing drugs and vaccines.</p>
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