Preparative supercritical fluid chromatography as green purification methodology
Résumé
In this work, a tentative of answer is given to the question: to which extent preparative scale supercritical fluid chromatography can be considered as a green method. In the introduction, we present how supercritical liquid chromatography theoretically meets the six concepts of green analytical chemistry. Then, a first part is devoted to the greenness assessment indicators of the chomatographic methods involved. The metrics are defined together with some applications of those calculations. A second part decribes the recent evolutions aiming at lowering the environmental impact of preparative separation. Firstly through instrumentation improvements, such as computer-assisted method development, performances enhancement or using supercritical fluid-based processes. And secondly through the implementation of greener mobile phases, involving either the addition of water, the use of azeotropic ethanol or chaotropic agents. The review covers the frame of 2018 to 2022, but seminal papers are also given when needed.
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