Article Dans Une Revue Angewandte Chemie Année : 2017

Localized Supramolecular Peptide Self‐Assembly Directed by Enzyme‐Induced Proton Gradients

Jennifer Rodon Fores
Déborah Wagner
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Marc Schmutz
Morgane Rabineau
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Philippe Lavalle
Pierre Schaaf
Fouzia Boulmedais
Loïc Jierry

Résumé

Abstract Electrodes are ideal substrates for surface localized self‐assembly processes. Spatiotemporal control over such processes is generally directed through the release of ions generated by redox reactions occurring specifically at the electrode. The so‐used gradients of ions proved their effectiveness over the last decade but are in essence limited to material‐based electrodes, considerably reducing the scope of applications. Herein is described a strategy to enzymatically generate proton gradients from non‐conductive surfaces. In the presence of oxygen, immobilization of glucose oxidase (GOx) on a multilayer film provides a flow of protons through enzymatic oxidation of glucose by GOx. The confined acidic environment located at the solid–liquid interface allows the self‐assembly of Fmoc‐AA‐OH (Fmoc=fluorenylmethyloxycarbonyl and A=alanine) dipeptides into β‐sheet nanofibers exclusively from and near the surface. In the absence of oxygen, a multilayer nanoreactor containing GOx and horseradish peroxidase (HRP) similarly induces Fmoc‐AA‐OH self‐assembly.

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Dates et versions

hal-04977338 , version 1 (05-03-2025)

Identifiants

Citer

Jennifer Rodon Fores, Miguel Leonardo Martinez Mendez, Xiyu Mao, Déborah Wagner, Marc Schmutz, et al.. Localized Supramolecular Peptide Self‐Assembly Directed by Enzyme‐Induced Proton Gradients. Angewandte Chemie, 2017, 129 (50), pp.16200-16204. ⟨10.1002/ange.201709029⟩. ⟨hal-04977338⟩
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