Article Dans Une Revue Sleep Medicine Année : 2025

Determinants of substance use patterns in patients with narcolepsy type 1: A multi-center comparative cross-sectional study

Déterminants des modalités d'usage de substances chez les patients avec narcolepsie de type 1: une étude comparative transversale multicentrique

1 HCL - Hospices Civils de Lyon
2 UCBL - Université Claude Bernard Lyon 1
3 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
4 UMRESTTE UMR_T9405 - Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
5 Fondation Formation universitaire à distance Suisse (UniDistance)
6 CRNL-PAM - Équipe Perception, Attention, Mémoire - Perception, Attention, Memory Team
7 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
8 CHU Pitié-Salpêtrière [AP-HP]
9 INM - Institut des Neurosciences de Montpellier
10 INCI - Institut des Neurosciences Cellulaires et Intégratives
11 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
12 Neurochirurgie [Hôpital Gui de Chauliac]
13 Hôpital Robert Debré
14 Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon]
15 Hôpital Raymond Poincaré (Garches) [GHU AP-HP Université Paris-Saclay]
16 Centre du Sommeil et de la Vigilance [Paris]
17 INS - Institut de Neurosciences des Systèmes
18 TIMONE - Hôpital de la Timone [CHU - APHM]
19 ToNIC - Toulouse NeuroImaging Center
20 AP-HP Hôpital universitaire Robert-Debré [Paris]
21 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
22 VIFASOM (URP_7330) - Sommeil-Vigilance-Fatigue et Santé Publique
23 UBE - Université Bourgogne Europe
24 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
25 MITOVASC-CARME - MitoVasc - Équipe CarME (Cardiovascular Pathophysiology)
26 CHU Angers - Centre Hospitalier Universitaire d'Angers
27 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
28 CNRS - Centre National de la Recherche Scientifique
29 Neurophysiologie Clinique - Unité des troubles du sommeil [Lille]
30 Hôpital Roger Salengro [Lille]
31 CIC Hôpital Bichat
32 SANPSY - Sommeil, Addiction et Neuropsychiatrie [Bordeaux]
33 RESHAPE - Inserm U1290 - UCBL1 - Research on Healthcare Performance
Pauline Dodet
Manon Brigandet
  • Fonction : Auteur

Résumé

In this multi-center cross-sectional study, we compared substance use patterns (SUPs) between patients with narcolepsy type 1 (NT1) and controls, and investigated, among patients, factors associated with the consumption of the main psychoactive substances. Methods: Adult patients with NT1 and controls completed questionnaires about tobacco, alcohol, and cannabis use patterns. Unadjusted bivariable then multivariate analyses (adjusted for sex, age, education, family status, and depression) were performed to compare SUPs between controls and patients, and to explore sociodemographic, psycho-behavioral, and clinical determinants of consumptions. Results: We included 235 patients (63.8 % women, 36.4 ± 14.7 years) and 166 controls (69.9 % women, 40.3 ± 14.4 years). Substances co-consumptions were frequent in both groups. Patients with NT1 were more frequently current smokers (32.3 % vs. 20.1 %, p < 0.01) or e-cigarettes users (12.1 % vs 2.4 %, p < 0.001) than controls, while no difference was observed for cannabis use and alcohol misuse. Only the increased likelihood of vaping remained significant in adjusted analysis. Among NT1 patients, smoking was associated with disrupted nighttime sleep (OR[95%CI] = 2.28[1.02-5.12], p < 0.05) and less obesity (OR = 0.24[0.09-0.59], p < 0.05). Alcohol misuse was associated with sleep paralysis (OR = 2.11[1.13-3.91], p < 0.05) and treatments (modafinil: OR = 2.14[1.15-4.01], p < 0.05; sodium oxybate: OR = 0.41[0.17-0.97], p < 0.05). Tobacco and cannabis consumptions were associated with lower physical activity (OR = 0.46 [0.24-0.87], p < 0.05 and OR = 0.25 [0.10-0.66], p < 0.01). Alcohol misuse and cannabis use were associated with rule breaking behaviors (OR = 5.89[1.61-21.60], p < 0.05 and OR = 8.52 [1.79-40.48], p = 0.01). Conclusion: Patients with NT1 do not seem less vulnerable to psychoactive substance use/misuse. Consumptions patterns are associated with multiple dimensions of the disease including sleep-related symptoms, comorbidities, treatments, and psycho-behavioral factors.

Fichier principal
Vignette du fichier
2025_Sleep Medicine_NarcAdd.pdf (877.81 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04975089 , version 1 (03-03-2025)

Licence

Identifiants

Citer

Laure Peter-Derex, Emmanuel Fort, Benjamin Putois, Nora Martel, François Ricordeau, et al.. Determinants of substance use patterns in patients with narcolepsy type 1: A multi-center comparative cross-sectional study. Sleep Medicine, 2025, 129, pp.148-166. ⟨10.1016/j.sleep.2025.02.037⟩. ⟨hal-04975089⟩
5485 Consultations
425 Téléchargements

Altmetric

Partager

  • More