Article Dans Une Revue JAMA Network Open Année : 2025

Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease

Oscar Werner
  • Fonction : Auteur
Gregoire de la Villeon
  • Fonction : Auteur
Sophie Guillaumont
  • Fonction : Auteur
Victor Pommier
  • Fonction : Auteur
Isabelle Denjoy
  • Fonction : Auteur
Philippe Charron
  • Fonction : Auteur
Philippe Chevalier
  • Fonction : Auteur
Lauriane Cornuault
  • Fonction : Auteur
Caroline Besnard-Neyraud
  • Fonction : Auteur
Frederic Sacher
  • Fonction : Auteur
Patricia Reant
  • Fonction : Auteur
Marie-Christine Picot
  • Fonction : Auteur
Hamouda Abassi
  • Fonction : Auteur
Aymeric Boisson
  • Fonction : Auteur
Anne Requirand
  • Fonction : Auteur
Annie Auer
  • Fonction : Auteur
Vincent Probst
  • Fonction : Auteur
Solène Prigent
  • Fonction : Auteur
Quentin Hauet
  • Fonction : Auteur
Christelle Haddad
  • Fonction : Auteur
Claire Bertail-Galoin
  • Fonction : Auteur
Xavier Iriart
  • Fonction : Auteur
Julie Thomas-Chabaneix
Pierre-Marie Duboue
  • Fonction : Auteur
Amandine Ruissel
  • Fonction : Auteur
Jean-Bernard Selly
  • Fonction : Auteur

Résumé

Importance: Historical restrictions on children with inherited cardiac arrhythmia or cardiomyopathy have been implemented to mitigate the potential risk of sudden death, but these limitations can be detrimental to overall health and cardiopulmonary fitness.Objectives: To evaluate cardiopulmonary fitness and physical activity among children with inherited cardiac disease and identify the factors associated with maximum oxygen uptake (V̇o2max) in this population.Design, Setting, and Participants: This cross-sectional, multicenter, prospective controlled study was conducted in 7 tertiary care expert centers for inherited cardiac disease in France from February 1, 2021, to June 20, 2023, with a 2-week follow-up. Participants included 100 children and adolescents aged 6 to 17 years with inherited cardiac arrhythmia or cardiomyopathy who were compared with 107 sex- and age-matched controls.Main Outcomes and Measures: Maximum oxygen uptake was assessed using cardiopulmonary exercise testing, and results were expressed using pediatric reference z score values. The main determinants of V̇o2max included clinical (New York Heart Association [NYHA] functional class, treatment, echocardiographic, and electrocardiogram variables), functional (cardiopulmonary exercise test parameters), sociodemographic (sex, schooling, and parents’ education), and behavioral (physical activity and motivation) characteristics.Results A total of 100 patients (mean [SD] age, 12.7 [3.1] years; 52 boys [52.0%]) and 107 controls (mean [SD] age, 11.7 [3.3] years; 54 boys [50.5%]) were included. The V̇o2max was lower in patients than controls, expressed as z scores (mean [SD] score, −1.49 [1.48] vs −0.16 [0.97]; P < .001) or raw values (mean [SD] value, 32.2 [7.9] vs 40.2 [8.5] mL/kg/min; P < .001). Moderate to vigorous physical activity levels were lower in patients than in controls (mean [SD] level, 42.0 [23.6] vs 48.2 [20.4] min/d; P = .009). The final multivariable model explained 80% of the V̇o2max by integrating clinical (lower NYHA functional class, absence of ventricular dilatation, and absence of implantable cardioverter-defibrillator), functional (higher forced vital capacity and ventilatory anaerobic threshold), sociodemographic (male sex, normal progression of schooling, and higher maternal educational level), and behavioral (higher self-reported physical activity and motivation toward physical activity) parameters.Conclusions and Relevance: This cross-sectional study suggests that levels of cardiopulmonary fitness and physical activity were lower in children and adolescents with inherited cardiac disease than in healthy controls, even after adjusting for use of β-blockers and using modern pediatric reference models. Assessing cardiopulmonary fitness among children with inherited cardiac disease can contribute to engaging in a shared decision-making process for sports participation and preventive interventions, such as early cardiac rehabilitation programs.

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hal-04966817 , version 1 (26-02-2025)

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Luc Souilla, Oscar Werner, Helena Huguet, Arthur Gavotto, Marie Vincenti, et al.. Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease. JAMA Network Open, 2025, 8 (2), pp.e2461795. ⟨10.1001/jamanetworkopen.2024.61795⟩. ⟨hal-04966817⟩
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