Article Dans Une Revue Nature Communications Année : 2024

Regional patterns of human cortex development correlate with underlying neurobiology

Leon Lotter
Amin Saberi
Justine Hansen
Bratislav Misic
Casey Paquola
  • Fonction : Auteur
Gareth Barker
Arun Bokde
Sylvane Desrivières
Herta Flor
Antoine Grigis
  • Fonction : Auteur
Hugh Garavan
Penny Gowland
Andreas Heinz
Rüdiger Brühl
Tomáš Paus
Luise Poustka
  • Fonction : Auteur
Sarah Hohmann
Juliane Fröhner
Michael Smolka
Nilakshi Vaidya
Henrik Walter
Robert Whelan
Gunter Schumann
Frauke Nees
Tobias Banaschewski
Simon Eickhoff
  • Fonction : Auteur
Juergen Dukart

Résumé

Abstract Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of the variance associated with a lifespan model of regional cortical thickness trajectories. In contrast, modeled cortical thickness change patterns during adulthood are best explained by cholinergic and glutamatergic neurotransmitter receptor and transporter distributions. These relationships are supported by developmental gene expression trajectories and translate to individual longitudinal data from over 8000 adolescents, explaining up to 59% of developmental change at cohort- and 18% at single-subject level. Integrating neurobiological brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand brain development and aging in living humans.

Dates et versions

hal-04964567 , version 1 (24-02-2025)

Identifiants

Citer

Leon Lotter, Amin Saberi, Justine Hansen, Bratislav Misic, Casey Paquola, et al.. Regional patterns of human cortex development correlate with underlying neurobiology. Nature Communications, 2024, 15 (1), pp.7987. ⟨10.1038/s41467-024-52366-7⟩. ⟨hal-04964567⟩
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