Article Dans Une Revue (Article De Synthèse) Current Opinion in Microbiology Année : 2022

Repurposing of Plasmodium falciparum var genes beyond the blood stage

Résumé

A commonly observed survival strategy in protozoan parasites is the sequential expression of clonally variant-surface antigens to avoid elimination by the host's immune response. In malariacausing P. falciparum, the immunovariant erythrocytemembrane protein-1 (PfEMP1) adhesin family, encoded by var genes, is responsible for both antigenic variation and cytoadherence of infected erythrocytes to the microvasculature. Until recently, the biological function of these variant genes was believed to be restricted to intraerythrocytic developmental stages. With the advent of new technologies, var gene expression has been confirmed in transmission and preerythrocytic stages. Here, we discuss how repurposing of var gene expression beyond chronic blood-stage infection may be critical for successful transmission.

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hal-04959476 , version 1 (20-02-2025)

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Eliana Real, Flore Nardella, Artur Scherf, Liliana Mancio-Silva. Repurposing of Plasmodium falciparum var genes beyond the blood stage. Current Opinion in Microbiology, 2022, 70, pp.102207. ⟨10.1016/j.mib.2022.102207⟩. ⟨hal-04959476⟩

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