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              <p>In France, we are experiencing dierent waves of COVID-19, the importance of whichis undermining our health care system. We try to identify as early as possible hospital-ized patients who are at risk of developing a severe form of COVID-19. The worsening ofthe disease is in part related to an acute respiratory distress syndrome related to immunesystem hyperactivation. It has been clearly demonstrated that co-morbidity factors relatedto dysmetabolic pathologies (diabetes, obesity, hypertension, etc.) are associated with se-vere forms. The pathophysiology of SARS-CoV2 infection has shown that this virus inducessignicant metabolic disturbances, probably related, at least in part, to the inactivation ofangiotensin 2-converting enzyme, the gateway to the virus. Metabolomics has proven to bea reliable method for deep phenotyping and biomarker discovery. To date, it has been usedprimarily as a method to study metabolic perturbations induced by SARS-COV2 infection.This allows us to hypothesize that a metabolomics approach will lead to the discovery ofmetabolic biomarkers of aggravation. We have built a sample bank of more than 500 pa-tients hospitalized at Grenoble Alpes Hospital. We collected blood from patients within 3days of hospitalization and stored the plasma within 4 hours. The teams of this consortiumhave brought together complementary and competent partners in the elds of infectiology,viral immunity, medical biochemistry or in the eld of metabolomics and biostatistics. Thisambitious translational research project could provide new metabolic biomarker candidatesof COVID-19 severity, allowing to stratify patients and anticipate intensive care bed man-agement.</p>
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