Poster De Conférence Année : 2018

Development of a new calcium phosphate/PCL graded scaffolds in view of biomedical applications

Résumé

Scaffolds for bone tissue engineering require a combination of bioactivity and biodegradation on the sample surface and high mechanical properties in the bulk. This work presents an original calcium phosphate (CaP)/polycaprolactone (PCL) scaffold with a gradation of composition and porosity fraction from bulk to surface. The scaffold is made of three layers: (i) a dense hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) core, (ii) a macroporous HA/β-TCP transition layer and (iii) a macroporous PCL/(HA/β-TCP) external layer. The gradation of composition and porosity consisted of a gradation of the HA/β-TCP weight ratio and an increase of volume fraction of pores. The core was first obtained by gel-casting. Then the transition layer was fabricated around the core by gel-casting combined with the use of porogens. After sintering of the two-layer samples, the outer composite layer was obtained by a solvent casting/particle leaching process. The microstructure, phase composition and biodegradation of the scaffolds were characterized. The gradation of porosity was clearly obtained. However, the gradation of phase composition was less pronounced due to an important decomposition of the HA phase into β-TCP during thermal treatment. An in vitro dissolution test was performed by immersing the scaffolds in a TRIS solution. After immersion, the scaffolds were characterized by X-ray tomography, X-ray diffraction and the evolution of weight loss was followed. The results show a dissolution phenomenon with possible differentiated mechanisms in the different layers, in relation with the targeted multi-functionality.

Domaines

Fichier principal
Vignette du fichier
2018-09_CIEC16_Poster.pdf (859.16 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-04956130 , version 1 (19-02-2025)

Licence

Identifiants

  • HAL Id : hal-04956130 , version 1

Citer

Clémence Petit, Jean-Marc Tulliani, Paola Palmero, Sylvain Meille, Solene Tadier, et al.. Development of a new calcium phosphate/PCL graded scaffolds in view of biomedical applications. 16th European Inter-Regional Conference on Ceramics, Sep 2018, Turin, Italy. ⟨hal-04956130⟩
47 Consultations
37 Téléchargements

Partager

  • More