<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04947028v2</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T00:56:24+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Meta-Analysis models with group structure for pleiotropy detection at gene and variant level  using summary statistics from multiple datasets</title>
            <author role="aut">
              <persName>
                <forename type="first">Pierre‐emmanuel</forename>
                <surname>Sugier</surname>
              </persName>
              <idno type="idhal" notation="numeric">1297239</idno>
              <idno type="halauthorid" notation="string">2449713-1297239</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5846-1104</idno>
              <idno type="IDREF">https://www.idref.fr/250091216</idno>
              <idno type="VIAF">https://viaf.org/viaf/792160483682704990418</idno>
              <affiliation ref="#struct-1004645"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yazdan</forename>
                <surname>Asgari</surname>
              </persName>
              <idno type="idhal" notation="numeric">1278646</idno>
              <idno type="halauthorid" notation="string">2884461-1278646</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6993-6956</idno>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mohammed</forename>
                <surname>Sedki</surname>
              </persName>
              <email type="md5">09a28d9ee4d448bfe2264a57b5a62b65</email>
              <email type="domain">universite-paris-saclay.fr</email>
              <idno type="idhal" notation="numeric">1121477</idno>
              <idno type="halauthorid" notation="string">665975-1121477</idno>
              <affiliation ref="#struct-419361"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thérèse</forename>
                <surname>Truong</surname>
              </persName>
              <email type="md5">86501436e243717687bd61c3dc6fb2da</email>
              <email type="domain">vjf.inserm.fr</email>
              <idno type="idhal" notation="string">therese-truong</idno>
              <idno type="idhal" notation="numeric">989756</idno>
              <idno type="halauthorid" notation="string">153839-989756</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2943-6786</idno>
              <idno type="IDREF">https://www.idref.fr/122218639</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=hOQcw4sAAAAJ</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-2837-2013</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-2837-2013</idno>
              <affiliation ref="#struct-1051097"/>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-419361"/>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Liquet</surname>
              </persName>
              <email type="md5">1cb6a0ba9c1858f978bd0959e5e096c0</email>
              <email type="domain">univ-pau.fr</email>
              <idno type="idhal" notation="string">benoit-liquet</idno>
              <idno type="idhal" notation="numeric">174386</idno>
              <idno type="halauthorid" notation="string">899-174386</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8136-2294</idno>
              <idno type="IDREF">https://www.idref.fr/070746095</idno>
              <affiliation ref="#struct-87850"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Benoit</forename>
                <surname>Liquet</surname>
              </persName>
              <email type="md5">1cb6a0ba9c1858f978bd0959e5e096c0</email>
              <email type="domain">univ-pau.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1">
              <date type="whenSubmitted">2025-02-14 00:48:37</date>
            </edition>
            <edition n="v2" type="current">
              <date type="whenSubmitted">2025-10-13 08:52:40</date>
              <date type="whenModified">2026-04-29 17:27:59</date>
              <date type="whenReleased">2025-10-20 08:50:51</date>
              <date type="whenProduced">2025-12-31</date>
              <date type="whenEndEmbargoed">2025-10-13</date>
              <ref type="file" target="https://hal.science/hal-04947028v2/document">
                <date notBefore="2025-10-13"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04947028v2/file/main_final_hall.pdf" id="file-5310922-4548680">
                <date notBefore="2025-10-13"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="468616">
                <persName>
                  <forename>Benoit</forename>
                  <surname>Liquet</surname>
                </persName>
                <email type="md5">1cb6a0ba9c1858f978bd0959e5e096c0</email>
                <email type="domain">univ-pau.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04947028</idno>
            <idno type="halUri">https://hal.science/hal-04947028</idno>
            <idno type="halBibtex">sugier:hal-04947028</idno>
            <idno type="halRefHtml">&lt;i&gt;Biostatistics&lt;/i&gt;, 2025, 26 (1), &lt;a target="_blank" href="https://dx.doi.org/10.1093/biostatistics/kxaf037"&gt;&amp;#x27E8;10.1093/biostatistics/kxaf037&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Biostatistics, 2025, 26 (1), &amp;#x27E8;10.1093/biostatistics/kxaf037&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-5310922-4548680"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-PAU">Université de Pau et des Pays de l'Adour - E2S UPPA</idno>
            <idno type="stamp" n="LMA-PAU" corresp="UNIV-PAU">Laboratoire de Mathématiques et de leurs Applications de Pau - IPRA</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="INSMI">CNRS-INSMI - INstitut des Sciences Mathématiques et de leurs Interactions</idno>
            <idno type="stamp" n="CESP" corresp="INSERM">Centre de recherche en Épidémiologie et Santé des Populations</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="IGR" corresp="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="MAP5">MAP5</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SCIENCES">Université Paris Cité - Faculté des Sciences</idno>
            <idno type="stamp" n="UVSQ-UPSACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-UPSACLAY</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UPPA-OA" corresp="UNIV-PAU">uppa-oa</idno>
            <idno type="stamp" n="GS-SANTE-PUBLIQUE">Graduate School Santé publique</idno>
            <idno type="stamp" n="UPPA-STEE" corresp="UNIV-PAU">UPPA-Collège-STEE</idno>
            <idno type="stamp" n="UPPA-COLLEGES">UPPA STEE EI SSH</idno>
            <idno type="stamp" n="LMA-PS" corresp="LMA-PAU">Probabilités et statistique</idno>
            <idno type="stamp" n="IPRA" corresp="UNIV-PAU">Institut Pluridisciplinaire de Recherche Appliquée</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Meta-Analysis models with group structure for pleiotropy detection at gene and variant level  using summary statistics from multiple datasets</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre‐emmanuel</forename>
                    <surname>Sugier</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1297239</idno>
                  <idno type="halauthorid" notation="string">2449713-1297239</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5846-1104</idno>
                  <idno type="IDREF">https://www.idref.fr/250091216</idno>
                  <idno type="VIAF">https://viaf.org/viaf/792160483682704990418</idno>
                  <affiliation ref="#struct-1004645"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yazdan</forename>
                    <surname>Asgari</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1278646</idno>
                  <idno type="halauthorid" notation="string">2884461-1278646</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6993-6956</idno>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mohammed</forename>
                    <surname>Sedki</surname>
                  </persName>
                  <email type="md5">09a28d9ee4d448bfe2264a57b5a62b65</email>
                  <email type="domain">universite-paris-saclay.fr</email>
                  <idno type="idhal" notation="numeric">1121477</idno>
                  <idno type="halauthorid" notation="string">665975-1121477</idno>
                  <affiliation ref="#struct-419361"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thérèse</forename>
                    <surname>Truong</surname>
                  </persName>
                  <email type="md5">86501436e243717687bd61c3dc6fb2da</email>
                  <email type="domain">vjf.inserm.fr</email>
                  <idno type="idhal" notation="string">therese-truong</idno>
                  <idno type="idhal" notation="numeric">989756</idno>
                  <idno type="halauthorid" notation="string">153839-989756</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2943-6786</idno>
                  <idno type="IDREF">https://www.idref.fr/122218639</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=hOQcw4sAAAAJ</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-2837-2013</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-2837-2013</idno>
                  <affiliation ref="#struct-1051097"/>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-419361"/>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Liquet</surname>
                  </persName>
                  <email type="md5">1cb6a0ba9c1858f978bd0959e5e096c0</email>
                  <email type="domain">univ-pau.fr</email>
                  <idno type="idhal" notation="string">benoit-liquet</idno>
                  <idno type="idhal" notation="numeric">174386</idno>
                  <idno type="halauthorid" notation="string">899-174386</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8136-2294</idno>
                  <idno type="IDREF">https://www.idref.fr/070746095</idno>
                  <affiliation ref="#struct-87850"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11226</idno>
                <idno type="issn">1465-4644</idno>
                <idno type="eissn">1468-4357</idno>
                <title level="j">Biostatistics</title>
                <imprint>
                  <publisher>Oxford University Press (OUP)</publisher>
                  <biblScope unit="volume">26</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <date type="datePub">2025-12-31</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/biostatistics/kxaf037</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="stat">Statistics [stat]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>&lt;div&gt;&lt;p&gt;Genome-wide association studies (GWAS) have highlighted the importance of pleiotropy in human diseases, where one gene can impact two or more unrelated traits. Examining shared genetic risk factors across multiple diseases can enhance our understanding of these conditions by pinpointing new genes and biological pathways involved. Furthermore, with an increasing wealth of GWAS summary statistics available to the scientific community, leveraging these findings across multiple phenotypes could unveil novel pleiotropic associations. Existing selection methods examine pleiotropy association one by one at a scale of either the genetic variant or the gene, and though cannot consider all the genetic information at the same time. To address this limitation, we propose a new approach called MPSG (Meta-analysis model adapted for Pleiotropy Selection with Group structure). This method performs a penalised multivariate meta-analysis method adapted for pleiotropy and takes into account the group structure information nested in the data to select relevant variants and genes (or pathways) from all the genetic information. To do so, we implemented an alternating direction method of multipliers (ADMM) algorithm. We compared the performance of the method with other benchmark meta-analysis approaches as GCPBayes, PLACO, and ASSET by considering as inputs different kinds of summary statistics. We provide an application of our method to the identification of potential pleiotropic genes between breast and thyroid cancers.&lt;/p&gt;&lt;p&gt;In this case, V s is in the form of a diagonal matrix.&lt;/p&gt;&lt;/div&gt; &lt;div&gt;Inverse-variance estimator for meta-analysis design&lt;p&gt;Traditional meta-analysis methods propose to analyse each covariate separately. Though, a multivariate meta-analysis version called the inverse-variance estimator ( Lin and Zeng, 2010]. Motivated by this estimator, a sparse meta-analysis (SMA) method has been developed to perform variable selection in meta-analysis when raw data are not available [He et al., 2016].&lt;/p&gt;&lt;/div&gt;</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1004645" status="VALID">
          <idno type="IdRef">200850709</idno>
          <idno type="ISNI">0000000403710374</idno>
          <idno type="RNSR">200412801B</idno>
          <idno type="ROR">04yrrdj53</idno>
          <orgName>Mathématiques Appliquées Paris 5</orgName>
          <orgName type="acronym">MAP5 - UMR 8145</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>UFR Mathématiques et Informatique, 45 rue des Saints-Pères 75270 PARIS CEDEX 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://w3.mi.parisdescartes.fr/map5/</ref>
          </desc>
          <listRelation>
            <relation name="UMR 8145" active="#struct-302352" type="direct"/>
            <relation name="UMR8145" active="#struct-441569" type="direct"/>
            <relation name="UMR 8145" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1051097" status="VALID">
          <idno type="IdRef">156182254</idno>
          <idno type="ISNI">0000 0004 0638 6872 </idno>
          <idno type="RNSR">201019083D</idno>
          <idno type="ROR">https://ror.org/01ed4t417</idno>
          <orgName>Centre de recherche en épidémiologie et santé des populations</orgName>
          <orgName type="acronym">CESP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR U1018" active="#struct-81173" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300153" type="direct"/>
            <relation active="#struct-1066727" type="indirect"/>
            <relation name="U1018" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-156104" status="VALID">
          <idno type="IdRef">026387433</idno>
          <idno type="ROR">https://ror.org/0321g0743</idno>
          <orgName>Institut Gustave Roussy</orgName>
          <orgName type="acronym">IGR</orgName>
          <desc>
            <address>
              <addrLine>114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.gustaveroussy.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-87850" status="VALID">
          <idno type="IdRef">135610133</idno>
          <idno type="ISNI">0000000403829607</idno>
          <idno type="RNSR">200511822H</idno>
          <idno type="ROR">https://ror.org/00g669j87</idno>
          <idno type="Wikidata">Q30262288</idno>
          <orgName>Laboratoire de Mathématiques et de leurs Applications [Pau]</orgName>
          <orgName type="acronym">LMAP</orgName>
          <date type="start">2005-01-01</date>
          <desc>
            <address>
              <addrLine>LMAP (UMR 5142) - Bâtiment IPRA - Université de Pau et des Pays de l'Adour, Avenue de l'Université - BP 1155 64013 PAU CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lma-umr5142.univ-pau.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301085" type="direct"/>
            <relation name="UMR5142" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-302352" status="VALID">
          <idno type="IdRef">232435081</idno>
          <idno type="ISNI">000000040387052X</idno>
          <idno type="ROR">https://ror.org/050jcm728</idno>
          <orgName>Institut National des Sciences Mathématiques et de leurs Interactions - CNRS Mathématiques</orgName>
          <orgName type="acronym">INSMI-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CNRS - Campus Gérard Mégie - 3 rue Michel Ange - 75794 Paris cedex 16</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.insmi.cnrs.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-81173" status="VALID">
          <idno type="IdRef">03082057X</idno>
          <idno type="ISNI">0000 0001 2323 0229 </idno>
          <idno type="ROR">https://ror.org/03mkjjy25</idno>
          <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName>
          <orgName type="acronym">UVSQ</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uvsq.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300153" status="VALID">
          <idno type="ROR">https://ror.org/05n7yzd13</idno>
          <orgName>Hôpital Paul Brousse</orgName>
          <desc>
            <address>
              <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1066727" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1066727" status="VALID">
          <orgName>AP-HP. Université Paris Saclay</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.aphp.fr/groupes-hospitaliers-de-lap-hp</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301085" status="VALID">
          <idno type="IdRef">026403668</idno>
          <idno type="ISNI">000000012289818X</idno>
          <idno type="ROR">https://ror.org/01frn9647</idno>
          <idno type="Wikidata">Q572968</idno>
          <orgName>Université de Pau et des Pays de l'Adour</orgName>
          <orgName type="acronym">UPPA</orgName>
          <date type="start">1970-12-17</date>
          <desc>
            <address>
              <addrLine>Avenue de l'Université - BP 576 - 64012 Pau Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-pau.fr/fr/index.html</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>