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              <p>Introduction and objective. Some respiratory infections have been associated with dysbiosis of the human intestinal microbiota. Crosstalk between intestinal microbiota and local immune cells could influence the immune response at distal mucosal sites and thus oral supplementation with exogeneous beneficial bacteria could enhance respiratory defences toward pathogens. In this study, we examined the effect of the beneficial strain Lactobacillus plantarum CIRM653 on the inflammatory response induced by Klebsiella pneumoniae in vivo and in vitro. Material, Method and Results. Oral administration of L. plantarum CIRM653 to mice subsequently infected by K. pneumoniae via the nasal route reduced the pulmonary inflammation response, with decreased numbers of lung immune cells (macrophages, and neutrophils) and cytokines (KC, IL-6 and TNF- in the bronchoalveolar fluid. In vitro co-incubation of L. plantarum CIRM653 and K. pneumoniae with human dendritic cells and peripheral blood mononuclear cells resulted in decreased Th1 (IL-12p70; IFN-) and Th17 (IL-23, IL-17) and increased Treg (IL-10) cytokine levels compared to those observed with K. pneumoniae-infected cells. Neither K. pneumoniae nor L. plantarum CIRM653 had any effect on cytokine production by intestinal epithelial cells in vitro, but the induction of NF-B pathway and IL-8 and IL-6 production by K. pneumoniae in airway epithelial cells was significantly reduced when the pathogen was co-incubated with L. plantarum CIRM653. Conclusion. The remote modulation of K. pneumoniae inflammatory response by L. plantarum CIRM653 observed in this study supports the concept of immunomodulation by beneficial bacteria through the gut-lung axis.</p>
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