<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04931602</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T04:53:40+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group</title>
            <author role="aut">
              <persName>
                <forename type="first">Alessia</forename>
                <surname>Cavazza</surname>
              </persName>
              <email type="md5">40688fe625d82878f2b677a2ea843306</email>
              <email type="domain">ucl.ac.uk</email>
              <idno type="idhal" notation="numeric">1502804</idno>
              <idno type="halauthorid" notation="string">2951722-1502804</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Francisco</forename>
                <forename type="middle">J</forename>
                <surname>Molina-Estévez</surname>
              </persName>
              <idno type="halauthorid">3403214-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Álvaro</forename>
                <forename type="middle">Plaza</forename>
                <surname>Reyes</surname>
              </persName>
              <idno type="halauthorid">3403215-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Victor</forename>
                <surname>Ronco</surname>
              </persName>
              <idno type="halauthorid">3403216-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Asma</forename>
                <surname>Naseem</surname>
              </persName>
              <idno type="halauthorid">2072532-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Špela</forename>
                <surname>Malenšek</surname>
              </persName>
              <idno type="halauthorid">3403217-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Peter</forename>
                <surname>Pečan</surname>
              </persName>
              <idno type="halauthorid">3403218-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Annalisa</forename>
                <surname>Santini</surname>
              </persName>
              <idno type="halauthorid">3403219-0</idno>
              <affiliation ref="#struct-1004662"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paula</forename>
                <surname>Heredia</surname>
              </persName>
              <idno type="halauthorid">3403220-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Araceli</forename>
                <surname>Aguilar-González</surname>
              </persName>
              <idno type="halauthorid">3403221-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Houria</forename>
                <surname>Boulaiz</surname>
              </persName>
              <idno type="halauthorid">535816-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Qianqian</forename>
                <surname>Ni</surname>
              </persName>
              <idno type="halauthorid">3403222-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marina</forename>
                <surname>Cortijo-Gutierrez</surname>
              </persName>
              <idno type="halauthorid">3403223-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kristina</forename>
                <surname>Pavlovic</surname>
              </persName>
              <idno type="halauthorid">3403224-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Inmaculada</forename>
                <surname>Herrera</surname>
              </persName>
              <idno type="halauthorid">3403225-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Berta</forename>
                <surname>de la Cerda</surname>
              </persName>
              <idno type="halauthorid">3119474-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emilio</forename>
                <forename type="middle">M</forename>
                <surname>Garcia-Tenorio</surname>
              </persName>
              <idno type="halauthorid">3403226-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eva</forename>
                <surname>Richard</surname>
              </persName>
              <idno type="halauthorid">524181-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sergio</forename>
                <surname>Granados-Principal</surname>
              </persName>
              <idno type="halauthorid">3403227-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arístides</forename>
                <surname>López-Márquez</surname>
              </persName>
              <idno type="halauthorid">3403228-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mariana</forename>
                <surname>Köber</surname>
              </persName>
              <idno type="halauthorid">3403229-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marijana</forename>
                <surname>Stojanovic</surname>
              </persName>
              <idno type="halauthorid">3403230-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Melita</forename>
                <surname>Vidaković</surname>
              </persName>
              <idno type="halauthorid">1714436-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Irene</forename>
                <surname>Santos-Garcia</surname>
              </persName>
              <idno type="halauthorid">3403231-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lorea</forename>
                <surname>Blázquez</surname>
              </persName>
              <idno type="halauthorid">3403232-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emily</forename>
                <surname>Haughton</surname>
              </persName>
              <idno type="halauthorid">3403233-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dongnan</forename>
                <surname>Yan</surname>
              </persName>
              <idno type="halauthorid">3403234-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rosario</forename>
                <forename type="middle">María</forename>
                <surname>Sánchez-Martín</surname>
              </persName>
              <idno type="halauthorid">3403235-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Loubna</forename>
                <surname>Mazini</surname>
              </persName>
              <idno type="halauthorid">979719-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gloria</forename>
                <forename type="middle">Gonzalez</forename>
                <surname>Aseguinolaza</surname>
              </persName>
              <idno type="halauthorid">3403236-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Annarita</forename>
                <surname>Miccio</surname>
              </persName>
              <email type="md5">c8db23181f59cf7e467eb764d54895b3</email>
              <email type="domain">institutimagine.org</email>
              <idno type="idhal" notation="numeric">1189295</idno>
              <idno type="halauthorid" notation="string">1179694-1189295</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3409-9665</idno>
              <affiliation ref="#struct-1004662"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paula</forename>
                <surname>Rio</surname>
              </persName>
              <idno type="halauthorid">1449129-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lourdes</forename>
                <forename type="middle">R</forename>
                <surname>Desviat</surname>
              </persName>
              <idno type="halauthorid">3403237-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Manuel</forename>
                <forename type="middle">a F V</forename>
                <surname>Gonçalves</surname>
              </persName>
              <idno type="halauthorid">2951732-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ling</forename>
                <surname>Peng</surname>
              </persName>
              <email type="md5">9cf0f4af3aa809734ac1778038ec3c2a</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">ling-peng</idno>
              <idno type="idhal" notation="numeric">18631</idno>
              <idno type="halauthorid" notation="string">4901-18631</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3990-5248</idno>
              <idno type="IDREF">https://www.idref.fr/14998605X</idno>
              <affiliation ref="#struct-215109"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cecilia</forename>
                <surname>Jiménez-Mallebrera</surname>
              </persName>
              <idno type="halauthorid">3403238-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Francisco</forename>
                <forename type="middle">Martin</forename>
                <surname>Molina</surname>
              </persName>
              <idno type="halauthorid">3403239-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dhanu</forename>
                <surname>Gupta</surname>
              </persName>
              <idno type="halauthorid">2036075-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Duško</forename>
                <surname>Lainšček</surname>
              </persName>
              <idno type="halauthorid">2936670-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yonglun</forename>
                <surname>Luo</surname>
              </persName>
              <idno type="halauthorid">2076529-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Benabdellah</surname>
              </persName>
              <email type="md5">34ef3eada00a8018b9acf9f8590e68df</email>
              <email type="domain">genyo.es</email>
              <idno type="idhal" notation="numeric">1502805</idno>
              <idno type="halauthorid" notation="string">1864289-1502805</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Ling</forename>
                <surname>PENG</surname>
              </persName>
              <email type="md5">9cf0f4af3aa809734ac1778038ec3c2a</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-02-05 21:59:53</date>
              <date type="whenModified">2025-02-28 14:46:28</date>
              <date type="whenReleased">2025-02-11 08:48:23</date>
              <date type="whenProduced">2025-03-11</date>
              <date type="whenEndEmbargoed">2025-02-05</date>
              <ref type="file" target="https://hal.science/hal-04931602v1/document">
                <date notBefore="2025-02-05"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04931602v1/file/2025%20Molecular%20Therapy%20Gene%20Editing.pdf" id="file-4931602-4285997">
                <date notBefore="2025-02-05"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="379425">
                <persName>
                  <forename>Ling</forename>
                  <surname>PENG</surname>
                </persName>
                <email type="md5">9cf0f4af3aa809734ac1778038ec3c2a</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04931602</idno>
            <idno type="halUri">https://hal.science/hal-04931602</idno>
            <idno type="halBibtex">cavazza:hal-04931602</idno>
            <idno type="halRefHtml">&lt;i&gt;Molecular Therapy - Nucleic Acids&lt;/i&gt;, 2025, 36 (1), pp.102457. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.omtn.2025.102457"&gt;&amp;#x27E8;10.1016/j.omtn.2025.102457&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecular Therapy - Nucleic Acids, 2025, 36 (1), pp.102457. &amp;#x27E8;10.1016/j.omtn.2025.102457&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc-nd/4.0/">CC BY-NC-ND 4.0 - Attribution - Non-commercial use - No Derivative Works<ref corresp="#file-4931602-4285997"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="CINAM">Centre Interdisciplinaire de Nanoscience de Marseille</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Alessia</forename>
                    <surname>Cavazza</surname>
                  </persName>
                  <email type="md5">40688fe625d82878f2b677a2ea843306</email>
                  <email type="domain">ucl.ac.uk</email>
                  <idno type="idhal" notation="numeric">1502804</idno>
                  <idno type="halauthorid" notation="string">2951722-1502804</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Francisco</forename>
                    <forename type="middle">J</forename>
                    <surname>Molina-Estévez</surname>
                  </persName>
                  <idno type="halauthorid">3403214-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Álvaro</forename>
                    <forename type="middle">Plaza</forename>
                    <surname>Reyes</surname>
                  </persName>
                  <idno type="halauthorid">3403215-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Victor</forename>
                    <surname>Ronco</surname>
                  </persName>
                  <idno type="halauthorid">3403216-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Asma</forename>
                    <surname>Naseem</surname>
                  </persName>
                  <idno type="halauthorid">2072532-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Špela</forename>
                    <surname>Malenšek</surname>
                  </persName>
                  <idno type="halauthorid">3403217-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Peter</forename>
                    <surname>Pečan</surname>
                  </persName>
                  <idno type="halauthorid">3403218-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Annalisa</forename>
                    <surname>Santini</surname>
                  </persName>
                  <idno type="halauthorid">3403219-0</idno>
                  <affiliation ref="#struct-1004662"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paula</forename>
                    <surname>Heredia</surname>
                  </persName>
                  <idno type="halauthorid">3403220-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Araceli</forename>
                    <surname>Aguilar-González</surname>
                  </persName>
                  <idno type="halauthorid">3403221-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Houria</forename>
                    <surname>Boulaiz</surname>
                  </persName>
                  <idno type="halauthorid">535816-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Qianqian</forename>
                    <surname>Ni</surname>
                  </persName>
                  <idno type="halauthorid">3403222-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marina</forename>
                    <surname>Cortijo-Gutierrez</surname>
                  </persName>
                  <idno type="halauthorid">3403223-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kristina</forename>
                    <surname>Pavlovic</surname>
                  </persName>
                  <idno type="halauthorid">3403224-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Inmaculada</forename>
                    <surname>Herrera</surname>
                  </persName>
                  <idno type="halauthorid">3403225-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Berta</forename>
                    <surname>de la Cerda</surname>
                  </persName>
                  <idno type="halauthorid">3119474-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emilio</forename>
                    <forename type="middle">M</forename>
                    <surname>Garcia-Tenorio</surname>
                  </persName>
                  <idno type="halauthorid">3403226-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eva</forename>
                    <surname>Richard</surname>
                  </persName>
                  <idno type="halauthorid">524181-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sergio</forename>
                    <surname>Granados-Principal</surname>
                  </persName>
                  <idno type="halauthorid">3403227-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arístides</forename>
                    <surname>López-Márquez</surname>
                  </persName>
                  <idno type="halauthorid">3403228-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mariana</forename>
                    <surname>Köber</surname>
                  </persName>
                  <idno type="halauthorid">3403229-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marijana</forename>
                    <surname>Stojanovic</surname>
                  </persName>
                  <idno type="halauthorid">3403230-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Melita</forename>
                    <surname>Vidaković</surname>
                  </persName>
                  <idno type="halauthorid">1714436-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Irene</forename>
                    <surname>Santos-Garcia</surname>
                  </persName>
                  <idno type="halauthorid">3403231-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lorea</forename>
                    <surname>Blázquez</surname>
                  </persName>
                  <idno type="halauthorid">3403232-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emily</forename>
                    <surname>Haughton</surname>
                  </persName>
                  <idno type="halauthorid">3403233-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dongnan</forename>
                    <surname>Yan</surname>
                  </persName>
                  <idno type="halauthorid">3403234-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rosario</forename>
                    <forename type="middle">María</forename>
                    <surname>Sánchez-Martín</surname>
                  </persName>
                  <idno type="halauthorid">3403235-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Loubna</forename>
                    <surname>Mazini</surname>
                  </persName>
                  <idno type="halauthorid">979719-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gloria</forename>
                    <forename type="middle">Gonzalez</forename>
                    <surname>Aseguinolaza</surname>
                  </persName>
                  <idno type="halauthorid">3403236-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Annarita</forename>
                    <surname>Miccio</surname>
                  </persName>
                  <email type="md5">c8db23181f59cf7e467eb764d54895b3</email>
                  <email type="domain">institutimagine.org</email>
                  <idno type="idhal" notation="numeric">1189295</idno>
                  <idno type="halauthorid" notation="string">1179694-1189295</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3409-9665</idno>
                  <affiliation ref="#struct-1004662"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paula</forename>
                    <surname>Rio</surname>
                  </persName>
                  <idno type="halauthorid">1449129-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lourdes</forename>
                    <forename type="middle">R</forename>
                    <surname>Desviat</surname>
                  </persName>
                  <idno type="halauthorid">3403237-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Manuel</forename>
                    <forename type="middle">a F V</forename>
                    <surname>Gonçalves</surname>
                  </persName>
                  <idno type="halauthorid">2951732-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ling</forename>
                    <surname>Peng</surname>
                  </persName>
                  <email type="md5">9cf0f4af3aa809734ac1778038ec3c2a</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">ling-peng</idno>
                  <idno type="idhal" notation="numeric">18631</idno>
                  <idno type="halauthorid" notation="string">4901-18631</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3990-5248</idno>
                  <idno type="IDREF">https://www.idref.fr/14998605X</idno>
                  <affiliation ref="#struct-215109"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cecilia</forename>
                    <surname>Jiménez-Mallebrera</surname>
                  </persName>
                  <idno type="halauthorid">3403238-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Francisco</forename>
                    <forename type="middle">Martin</forename>
                    <surname>Molina</surname>
                  </persName>
                  <idno type="halauthorid">3403239-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dhanu</forename>
                    <surname>Gupta</surname>
                  </persName>
                  <idno type="halauthorid">2036075-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Duško</forename>
                    <surname>Lainšček</surname>
                  </persName>
                  <idno type="halauthorid">2936670-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yonglun</forename>
                    <surname>Luo</surname>
                  </persName>
                  <idno type="halauthorid">2076529-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Benabdellah</surname>
                  </persName>
                  <email type="md5">34ef3eada00a8018b9acf9f8590e68df</email>
                  <email type="domain">genyo.es</email>
                  <idno type="idhal" notation="numeric">1502805</idno>
                  <idno type="halauthorid" notation="string">1864289-1502805</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">107729</idno>
                <idno type="issn">2162-2531</idno>
                <title level="j">Molecular Therapy - Nucleic Acids</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">36</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">102457</biblScope>
                  <date type="datePub">2025-03-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.omtn.2025.102457</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">MT: Delivery Strategies</term>
                <term xml:lang="en">European Cooperation in Science and Technology</term>
                <term xml:lang="en">COST</term>
                <term xml:lang="en">GenE-HumDi</term>
                <term xml:lang="en">genome editing</term>
                <term xml:lang="en">base editors</term>
                <term xml:lang="en">delivery systems</term>
                <term xml:lang="en">regulatory guidelines</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bbm.bm">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bm">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>In the past decade, precise targeting through genome editing has emerged as a promising alternative to traditional therapeutic approaches. Genome editing can be performed using various platforms, where programmable DNA nucleases create permanent genetic changes at specific genomic locations due to their ability to recognize precise DNA sequences. Clinical application of this technology requires the delivery of the editing reagents to transplantable cells ex vivo or to tissues and organs for in vivo approaches, often representing a barrier to achieving the desired editing efficiency and safety. In this review, authored by members of the GenE-HumDi European Cooperation in Science and Technology (COST) Action, we described the plethora of delivery systems available for genome-editing components, including viral and non-viral systems, highlighting their advantages, limitations, and potential application in a clinical setting.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1004662" status="VALID">
          <idno type="IdRef">188538119</idno>
          <idno type="ISNI">0000 0004 0620 6624</idno>
          <idno type="RNSR">201420829J</idno>
          <idno type="ROR">https://ror.org/04z4fen17</idno>
          <orgName>Imagine - Institut des maladies génétiques (IHU)</orgName>
          <orgName type="acronym">Imagine - U1163</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>IHU Imagine, 156 rue de Vaugirard, 75015 PARIS et 24 Boulevard du Montparnasse, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.institutimagine.org/fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1163" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 1163" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-215109" status="VALID">
          <idno type="IdRef">149986475</idno>
          <idno type="RNSR">201220341M</idno>
          <idno type="ROR">0550dmh35</idno>
          <orgName>Centre Interdisciplinaire de Nanoscience de Marseille</orgName>
          <orgName type="acronym">CINaM</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>CINaM-CNRS Campus de Luminy Case 913 13288 Marseille Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cinam.univ-mrs.fr/cinam/index.php</ref>
          </desc>
          <listRelation>
            <relation name="UMR7325 / UPR3118" active="#struct-198056" type="direct"/>
            <relation name="UMR7325 / UPR3118" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>