Article Dans Une Revue Journal of Neurology Année : 2002

Neostigmine-induced alterations in fast phase of optokinetic responses in myasthenic ocular palsies

Jing Tian
  • Fonction : Auteur
Min Wei
  • Fonction : Auteur
Joseph Terdiman
  • Fonction : Auteur
Fuchuan Sun
  • Fonction : Auteur

Résumé

Closed-loop and open-loop optokinetic nystagmus (OKN) eye movements were recorded with an electromagnetic scleral search coil in 16 patients with myasthenic ocular palsies, 8 patients with nonmyasthenic ocular palsies, and 4 normal controls. We calculated the summation of fast-phase amplitude per second (SFPAps), mean of fast-phase amplitude (MFPA) and mean of fast-phase peak velocity (MFPV) of OKN before and after administration of neostigmine. Under open-loop conditions, the myasthenic patients group demonstrated distinct increases in three parameters: SFPAps (P < 0.000001), MFPA (P < 0.001) and MFPV (P < 0.001) following neostigmine injection, and the increase in SFPAps was greater than those of MFPA and MFPV (P < 0.02), while the other two groups showed no significant increases. Under closed-loop condition, only five of the myasthenic patients showed significant changes. These results suggest that the change in SFPAps during open-loop OKN before and after neostigmine administration was a specific measurement that differentiated patients with myasthenic ocular palsies from the other groups.

Dates et versions

hal-04914212 , version 1 (27-01-2025)

Identifiants

Citer

Jing Tian, Qing Yang, Min Wei, Joseph Terdiman, Fuchuan Sun. Neostigmine-induced alterations in fast phase of optokinetic responses in myasthenic ocular palsies. Journal of Neurology, 2002, 249 (7), pp.867-874. ⟨10.1007/s00415-002-0750-0⟩. ⟨hal-04914212⟩

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