Article Dans Une Revue Laboratory Investigation; a Journal of Technical Methods and Pathology Année : 1999

Monocyte expression of adhesion molecules in HIV-infected patients: variations according to disease stage and possible pathogenic role

Résumé

We used flow cytometry to study the expression of adhesion molecules at the cell surface and actin polymerization of whole-blood monocytes in 35 HIV-infected patients at different stages of the disease. Monocytes were activated in vivo, as demonstrated by increased expression of the adhesion molecule CD11b/CD18, reduced L-selectin antigen expression, and increased actin polymerization. These abnormalities were present in asymptomatic patients with CD4+ cell counts greater than 500/microl and did not increase with disease progression or viral load. Sialyl-Lewis x and CD31 expression at the monocyte surface was normal in asymptomatic and symptomatic non-AIDS patients. In contrast expression of both molecules was strongly reduced in patients with AIDS. This change, despite normal maximal CD11b/CD18 expression and normal maximal actin polymerization, could contribute to the increased susceptibility to bacterial infections in AIDS. In contrast enhanced monocyte activation may promote their transendothelial migration in non-AIDS patients, possibly explaining the macrophage infiltration that can occur early in the disease.

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hal-04901612 , version 1 (20-01-2025)

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  • HAL Id : hal-04901612 , version 1

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Sylvie Pillet, Marie Hélène Prevost, Anna Preira, Pierre‐marie Girard, N. Rogine, et al.. Monocyte expression of adhesion molecules in HIV-infected patients: variations according to disease stage and possible pathogenic role. Laboratory Investigation; a Journal of Technical Methods and Pathology, 1999, 79 (7), pp.815-822. ⟨hal-04901612⟩
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