Innate immune memory process in Biomphalaria glabrata snails: a comparative multi-omic approach to decipher the function and role-played by the hemocyte immune cells against S. mansoni infections
Résumé
In the early 2000’s, several studies have highlighted the ability of invertebrates immune system to be primed, protecting the individual when meets the same pathogen twice during its life span, this process is called "innate immune memory" (IIM). This IIM has recently been demonstrated for B. glabrata snails against S. mansoni infestation and it is characterized by a shift from a cellular response to a humoral response, certainly carried by the snail innate immune cells, the hemocytes.
Objectives: Identify hemocyte sub-populations of B. glabrata involved in IIM response towards S. mansoni parasite based on different transcriptomic profiles using Single-Cell RNA sequencing technology.
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