Article Dans Une Revue Future Microbiology Année : 2023

Diagnostic Performances and Therapeutic Impact of the Unyvero Implant and Tissue Infection Multiplex PCR in Periprosthetic Joint Infections

Résumé

Aim: We evaluated the diagnostic performances of Unyvero Implant and Tissue Infection multiplex PCR (mPCR) (Curetis) and the clinical impact of this PCR on therapeutic decisions. Materials & methods: A mPCR was performed on 33 joint fluids in addition to standard culture. A group of experts analyzed a posteriori the impact of the mPCR in the patient management. Results: The rate of concordance with culture was 74% (20/27). The sensitivity of the PCR was 59% and the specificity 90%. Clinicians would have started an appropriate treatment sooner for six patients (from 2 to 22 days earlier). Conclusion: The PCR would improve the management of 22% of the patients. For other patients, mPCR results have to be completed with the culture.

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hal-04885714 , version 1 (14-01-2025)

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Claire Richarme, Patricia Pavese, Brice Rubens-Duval, Olivier Seurat, Marion Le Marechal, et al.. Diagnostic Performances and Therapeutic Impact of the Unyvero Implant and Tissue Infection Multiplex PCR in Periprosthetic Joint Infections. Future Microbiology, 2023, 18 (11), pp.723-734. ⟨10.2217/fmb-2022-0245⟩. ⟨hal-04885714⟩
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