We present a novel experimental setup called miniBLAST, which enables systematic and repeatable laboratory tests of structures subjected to blast loads. The explosive source is based on the discharge of high electrical loads on a thin conductor, producing repeatable blast-type shock waves of controlled intensity. Conducting blast experiments under safe laboratory conditions offers significant advantages over large-scale experiments, which are expensive, require specialized personnel, and face repeatability issues. In this work, we provide a comprehensive description of the setup’s design rationale and technical characteristics. We place particular emphasis on the installation phases, safety, and metrology. The explosive source is analyzed and the signature of blast waves is retrieved. Finally, we present an example of a masonry wall subjected to blast loads of varying intensity. We then report its dynamic response in three dimensions and at different time instances. This new experimental setup offers a cost-effective, safe, and repeatable method to study structural dynamics under blast loads, with results that can be upscaled to real structures. It also aids in evaluating numerical models and lays the groundwork for further investigations into blast effects and mitigation.