<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04878698</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T09:01:27+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Comparison of urinary 3-hydroxybenzo(a)Pyrene (3-OHBaP) and trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)Pyrene (TetraolBaP) as biomarkers of exposure to carcinogenic BaP</title>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Marquès</surname>
              </persName>
              <idno type="halauthorid">2958144-0</idno>
              <affiliation ref="#struct-1043053"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Renaud</forename>
                <surname>Persoons</surname>
              </persName>
              <email type="md5">d9330c1e31282f88a0db2965a3f72a2d</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="string">renaud-persoons</idno>
              <idno type="idhal" notation="numeric">944636</idno>
              <idno type="halauthorid" notation="string">728452-944636</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0700-2917</idno>
              <affiliation ref="#struct-1043053"/>
              <affiliation ref="#struct-257328"/>
              <affiliation ref="#struct-1103944"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Renaud</forename>
                <surname>PERSOONS</surname>
              </persName>
              <email type="md5">d9330c1e31282f88a0db2965a3f72a2d</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-01-10 09:50:01</date>
              <date type="whenModified">2026-03-26 16:30:05</date>
              <date type="whenReleased">2025-01-10 09:50:01</date>
              <date type="whenProduced">2024-10-23</date>
              <ref type="externalLink" target="https://doi.org/10.1016/j.ijheh.2024.114476"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1613136">
                <persName>
                  <forename>Renaud</forename>
                  <surname>PERSOONS</surname>
                </persName>
                <email type="md5">d9330c1e31282f88a0db2965a3f72a2d</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04878698</idno>
            <idno type="halUri">https://hal.science/hal-04878698</idno>
            <idno type="halBibtex">marques:hal-04878698</idno>
            <idno type="halRefHtml">&lt;i&gt;International Journal of Hygiene and Environmental Health&lt;/i&gt;, 2024, 263, 263, pp.114476. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ijheh.2024.114476"&gt;&amp;#x27E8;10.1016/j.ijheh.2024.114476&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">International Journal of Hygiene and Environmental Health, 2024, 263, 263, pp.114476. &amp;#x27E8;10.1016/j.ijheh.2024.114476&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SDE">Sciences De l'Environnement</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-EPSP" corresp="TIMC-IMAG">EPSP : Environnement et Prévention en Santé des Populations</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Comparison of urinary 3-hydroxybenzo(a)Pyrene (3-OHBaP) and trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)Pyrene (TetraolBaP) as biomarkers of exposure to carcinogenic BaP</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Marquès</surname>
                  </persName>
                  <idno type="halauthorid">2958144-0</idno>
                  <affiliation ref="#struct-1043053"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Renaud</forename>
                    <surname>Persoons</surname>
                  </persName>
                  <email type="md5">d9330c1e31282f88a0db2965a3f72a2d</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="string">renaud-persoons</idno>
                  <idno type="idhal" notation="numeric">944636</idno>
                  <idno type="halauthorid" notation="string">728452-944636</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0700-2917</idno>
                  <affiliation ref="#struct-1043053"/>
                  <affiliation ref="#struct-257328"/>
                  <affiliation ref="#struct-1103944"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">14478</idno>
                <idno type="issn">1438-4639</idno>
                <idno type="eissn">1618-131X</idno>
                <title level="j">International Journal of Hygiene and Environmental Health</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="serie">263</biblScope>
                  <biblScope unit="volume">263</biblScope>
                  <biblScope unit="pp">114476</biblScope>
                  <date type="datePub">2024-10-23</date>
                  <date type="dateEpub">2024-10-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ijheh.2024.114476</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sde.ie">Environmental Sciences/Environmental Engineering</classCode>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="sdv.ee.sant">Life Sciences [q-bio]/Ecology, environment/Health</classCode>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halDomain" n="sdv.tox">Life Sciences [q-bio]/Toxicology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Introduction: Biomonitoring of exposure to carcinogenic Benzo(a)Pyrene is generally based on measurement of urinary 3-hydroxybenzo(a)pyrene (3-OHBaP), but its analysis is complex and only reflects the BaP detoxification pathway. TetraolBaP, another BaP metabolite resulting from the metabolic activation pathway, is now available but has not yet been studied in occupational settings or compared with 3-OHBaP.Methods: Biomonitoring was carried out on 118 subjects working in the aluminium smelting industry. 3 urine samples were collected from each subject at the beginning and end of the working week. Pyrene metabolite (1-hydroxypyrene) and the two BaP biomarkers (3-OHBaP and TetraolBaP) were analysed using LC-Fluorescence and GC-NCI-MS-MS.Results: The workers studied were found to be highly exposed, with 1-OHP and 3-OHBaP frequently exceeding maximum recommended values in occupational settings. Maximum concentrations were measured at end of shift+16h for all biomarkers, highlighting dermal exposure and/or temporary storage. Correlations were strong between 1-OHP and 3-OHBaP (r = 0.68-0.75) as well as between 3-OHBaP and TetraolBaP (r = 0.67-0.78), and moderate between 1-OHP and TetraolBaP (r = 0.59-0.76). While TetraolBaP levels were higher at low PAH exposures, TetraolBaP increased much more slowly at high exposures, indicating progressive saturation of the bioactivation pathway. The [3-OHBaP]/[TetraolBaP] ratio was found to be significantly lower in chronically exposed workers. Urinary TetraolBaP levels corresponding to 1-OHP (2.5 μg/L or 1 μmol/mol creatinine) or 3-OHBaP (0.4 nmol/mol creatinine) guidance values were found to range between 0.84 and 0.95 nmol/mol creatinine.Conclusions: TetraolBaP, resulting from carcinogenic BaP's metabolic activation pathway, was shown to be a diagnostically specific and sensitive biomarker for determining subjects' toxic internal exposure to PAHs in different contexts (occupational settings, environment) and assessing health risks.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1043053" status="VALID">
          <orgName>Environnement et Prévention en Santé des Populations</orgName>
          <orgName type="acronym">TIMC-EPSP</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/epsp</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1103944" status="VALID">
          <orgName>Centre de ressources de pathologie professionnelle et environnementale - CHUGA</orgName>
          <orgName type="acronym">CRPPE - AuRA</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Michallon - Boulevard de la Chantourne 38700 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/patients-et-accompagnants/offre-de-soin/centre-regional-de-pathologie-professionnelle-et-environnementale-crppe-aura</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>