Cognitive Training for Visuospatial Processing in Children Aged 5½ to 6 Years Born Very Preterm With Working Memory Dysfunction - Archive ouverte HAL
Article Dans Une Revue JAMA Network Open Année : 2023

Cognitive Training for Visuospatial Processing in Children Aged 5½ to 6 Years Born Very Preterm With Working Memory Dysfunction

1 Hôpital Nord [CHU - APHM]
2 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
3 CHU Rouen
4 CHU Trousseau [APHP]
5 UPMC - Université Pierre et Marie Curie - Paris 6
6 PhAN - Physiopathologie des Adaptations Nutritionnelles
7 Centre Hospitalier Sud Francilien
8 SAINBIOSE - Santé Ingénierie Biologie Saint-Etienne
9 UJM - Université Jean Monnet - Saint-Étienne
10 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
11 CHU Estaing [Clermont-Ferrand]
12 IP - Institut Pascal
13 CHU Caen
14 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
15 CHU Reims - Hôpital universitaire Robert Debré [Reims]
16 UCBL - Université Claude Bernard Lyon 1
17 DevAH - Développement, Adaptation et Handicap
18 Maternité Régionale Adolphe Pinard [Nancy]
19 UNISTRA - Université de Strasbourg
20 CHU Montpellier = Montpellier University Hospital
21 TIMONE - Hôpital de la Timone [CHU - APHM]
22 EPOPé [CRESS - U1153 / UMR_A 1125] - Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique
23 Equipe SPHERE (CERPOP)
24 Service Epidémiologie clinique et santé publique [CHU Toulouse]
25 Hôpital Arnaud de Villeneuve [CHU Montpellier]
26 Pathogénèse et contrôle des infections chroniques (PCCI)
27 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
28 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
29 SESSAD - Services d’Education Spéciale et de Soins à Domicile [Marseille]
30 CRSA - Centre de Recherche Saint-Antoine
31 CREN - Centre de recherche en éducation de Nantes
32 Nantes Univ - Nantes Université
33 Hôpital de la Croix-Rousse [CHU - HCL]
34 URCOM - Unité de Recherche en Chimie Organique et Macromoléculaire
35 I2BC - Institut de Biologie Intégrative de la Cellule
36 Service Neurologie Pédiatrique [CHU Toulouse]
Stéphane Marret
  • Fonction : Auteur
Bernard Guillois
  • Fonction : Auteur
Valérie Dorriere Datin
  • Fonction : Auteur
Gwenaëlle Menard
  • Fonction : Auteur
Mélodie Pache
  • Fonction : Auteur
Ludovic-Mohamed Zahed
  • Fonction : Auteur
Mireille Denaveaut Boulay
  • Fonction : Auteur
Elodie Falque
  • Fonction : Auteur
Magali Rebattel
  • Fonction : Auteur
Karine Voirin
  • Fonction : Auteur
Sophie Rubio Gurung
  • Fonction : Auteur
Mélanie Rodriguez
  • Fonction : Auteur
Julie Oertel
  • Fonction : Auteur
Anne de Saint Martin
  • Fonction : Auteur
Claire Zores Koenig
  • Fonction : Auteur
Hélène Musmeaux
  • Fonction : Auteur
Lucille Schneider
  • Fonction : Auteur
Claire Lerat
  • Fonction : Auteur
Angélique Pannetier
  • Fonction : Auteur
Isabelle Pin
  • Fonction : Auteur
Thierry Debillon
  • Fonction : Auteur
Karine Guichardet
  • Fonction : Auteur
Patrick Zander
  • Fonction : Auteur
Elie Saliba
  • Fonction : Auteur
Valérie Benhammou
  • Fonction : Auteur
Monique Kaminski
  • Fonction : Auteur
Laetitia Marchand-Martin
  • Fonction : Auteur
Samira Medjahed
  • Fonction : Auteur
Johanne Pirrello
  • Fonction : Auteur
Julie Berbis
  • Fonction : Auteur
Pascal Auquier
  • Fonction : Auteur
Karine Baumstarck
  • Fonction : Auteur

Résumé

Importance Compared with term-born peers, children born very preterm generally perform poorly in executive functions, particularly in working memory and inhibition. By taking advantage of neuroplasticity, computerized cognitive training of working memory in those children could improve visuospatial processing by boosting visual inhibition via working memory. Objective To evaluate the long-term effect of cognitive working memory training on visuospatial processing in children aged 5½ to 6 years born very preterm who have working memory impairment. Design, Setting, and Participants This multicenter (18 French university hospitals), open-label randomized clinical trial with 2 parallel groups (EPIREMED) was conducted from November 2016 to April 2018, with the last follow-up during August 2019. Eligible children from the EPIPAGE 2 cohort were aged 5½ to 6 years, were born between 24 and 34 weeks’ gestation, and had a global intelligence quotient greater than 70 and a working memory index less than 85. Data were analyzed from February to December 2020. Intervention Children were randomized 1:1 to standard care management and a working memory cognitive training program (Cogmed software) for 8 weeks (25 sessions) (intervention) or to standard management (control). Main Outcomes and Measures The primary outcome was the visuospatial index score from the Wechsler Preschool and Primary Scale of Intelligence, 4th Edition. Secondary outcomes were working memory, intellectual functioning, executive and attention processes, language skills, behavior, quality of life, and schooling. Neurobehavioral assessments were performed at inclusion and after finishing training at 6 months (intermeditate assessment; secondary outcomes) and at 16 months (final assessment; primary outcome). Results There were 169 children randomized, with a mean (SD) age of 5 years 11 months (2 months); 91 (54%) were female. Of the participants, 84 were in the intervention group (57 of whom [68%] completed at least 15 cognitive training sessions) and 85 were in the control group. The posttraining visuospatial index score was not different between groups at a mean (SD) of 3.0 (1.8) months (difference, −0.6 points; 95% CI, −4.7 to 3.5 points) or 12.9 (2.6) months (difference, 0.1 points; 95% CI, −5.4 to 5.1 points). The working memory index score in the intervention group significantly improved from baseline at the intermediate time point (difference, 4.7 points; 95% CI, 1.2-8.1 points), but this improvement was not maintained at the final assessment. Conclusions and Relevance This randomized clinical trial found no lasting effect of a cognitive training program on visuospatial processing in children aged 5½ to 6 years with working memory disorders who were born very preterm. The findings suggest that this training has limited long-term benefits for improving executive function. Transient benefits seemed to be associated with the developmental state of executive functions. Trial Registration ClinicalTrials.gov Identifier: NCT02757794

Dates et versions

hal-04858451 , version 1 (29-12-2024)

Identifiants

Citer

Catherine Gire, Any Beltran Anzola, Stéphane Marret, Laurence Foix L’hélias, Jean-Christophe Roze, et al.. Cognitive Training for Visuospatial Processing in Children Aged 5½ to 6 Years Born Very Preterm With Working Memory Dysfunction. JAMA Network Open, 2023, 6 (9), pp.e2331988. ⟨10.1001/jamanetworkopen.2023.31988⟩. ⟨hal-04858451⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More