Journal Articles Journal of materials chemistry‎ B Year : 2024

Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study

Twiany Cruz-Dubois
  • Function : Author
Beatrice Louis
  • Function : Author
Laure Balasse
  • Function : Author
Vincent Nail
  • Function : Author

Abstract

Self-assembly is a powerful strategy for building nanosystems for biomedical applications. We have recently developed small amphiphilic dendrimers capable of self-assembling into nanomicelles for tumor imaging. In this context, we studied the impact of increased hydrophobicity of the amphiphilic dendrimer on hydrophilic/hydrophobic balance and consequently on the self-assembly and subsequent biodistribution. Remarkably, despite maintaining the exact same surface chemistry, similar zeta potential, and small size, the altered and enlarged hydrophobic component within the amphiphilic dendrimer led to enhanced stability of the self-assembled nanomicelles, with prolonged circulation time and massive accumulation in the liver. This study reveals that even structural alteration within the interior of nanomicelles can dramatically impact biodistribution profiles. This finding highlights the deeper complexity of rational design for nanomedicine and the need to consider factors other than surface charge and chemistry, as well as size, all of which significantly impact the biodistribution of self-assembling nanosystems..
Embargoed file
Embargoed file
0 4 0
Year Month Jours
Avant la publication
Tuesday, June 17, 2025
Embargoed file
Tuesday, June 17, 2025
Please log in to request access to the document

Dates and versions

hal-04851748 , version 1 (20-12-2024)

Licence

Identifiers

Cite

Tom Roussel, Twiany Cruz-Dubois, Beatrice Louis, Erik Laurini, Ling Ding, et al.. Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study. Journal of materials chemistry‎ B, inPress, ⟨10.1039/D4TB01266F⟩. ⟨hal-04851748⟩
25 View
16 Download

Altmetric

Share

More