Telomere Dynamics in Zebrafish Aging and Disease - Archive ouverte HAL
Article Dans Une Revue Cold Spring Harbor Perspectives in Biology Année : 2024

Telomere Dynamics in Zebrafish Aging and Disease

Résumé

Fish telomere lengths vary significantly across the numerous species, implicating diverse life strategies and environmental adaptations. Zebrafish have telomere dynamics that are comparable to humans and are emerging as a key model in which to unravel the systemic effects of telomere shortening on aging and interorgan communication. Here, we discuss zebrafish telomere biology, focusing on the organismal impact of telomere attrition beyond cellular senescence, with particular emphasis on how telomeric shortening in specific tissues can unleash widespread organ dysfunction and disease. This highlights a novel aspect of tissue communication, whereby telomere shortening in one organ can propagate through biological networks, influencing the aging process systemically. These discoveries position zebrafish as a valuable model for studying the complex interactions between telomeres, aging, and tissue cross talk, providing important insights with direct relevance to human health and longevity.
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Dates et versions

hal-04850161 , version 1 (19-12-2024)

Identifiants

Citer

Miguel Godinho Ferreira. Telomere Dynamics in Zebrafish Aging and Disease. Cold Spring Harbor Perspectives in Biology, 2024, pp.a041696. ⟨10.1101/cshperspect.a041696⟩. ⟨hal-04850161⟩
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