<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04831609</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T07:58:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia</title>
            <author role="aut">
              <persName>
                <forename type="first">Samuel</forename>
                <surname>Bersinger</surname>
              </persName>
              <idno type="halauthorid">3066496-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kevin</forename>
                <surname>Lagarde</surname>
              </persName>
              <idno type="halauthorid">2033710-0</idno>
              <affiliation ref="#struct-223805"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphael</forename>
                <surname>Marlu</surname>
              </persName>
              <idno type="halauthorid">2453309-0</idno>
              <affiliation ref="#struct-1082521"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gilles</forename>
                <surname>Pernod</surname>
              </persName>
              <email type="md5">4016f65f8ef2b07d7ce677d2b9f73ccb</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1367614</idno>
              <idno type="halauthorid" notation="string">250940-1367614</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6494-5984</idno>
              <affiliation ref="#struct-1090177"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Payen</surname>
              </persName>
              <email type="md5">0f8191dfd45e467a78b1f4954cfcd37a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="numeric">1477106</idno>
              <idno type="halauthorid" notation="string">395954-1477106</idno>
              <affiliation ref="#struct-257328"/>
              <affiliation ref="#struct-1042703"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jean-Francois</forename>
                <surname>Payen</surname>
              </persName>
              <email type="md5">0f8191dfd45e467a78b1f4954cfcd37a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-12-11 16:06:00</date>
              <date type="whenModified">2026-03-26 16:30:05</date>
              <date type="whenReleased">2024-12-11 16:06:00</date>
              <date type="whenProduced">2021-06-02</date>
              <ref type="externalLink" target="https://journals.lww.com/ccmjournal/Fulltext/2021/09000/Using_Nonheparin_Anticoagulant_to_Treat_a.31.aspx"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1609637">
                <persName>
                  <forename>Jean-Francois</forename>
                  <surname>Payen</surname>
                </persName>
                <email type="md5">0f8191dfd45e467a78b1f4954cfcd37a</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04831609</idno>
            <idno type="halUri">https://hal.science/hal-04831609</idno>
            <idno type="halBibtex">bersinger:hal-04831609</idno>
            <idno type="halRefHtml">&lt;i&gt;Critical Care Medicine&lt;/i&gt;, 2021, 49 (9), pp.e870-e873. &lt;a target="_blank" href="https://dx.doi.org/10.1097/CCM.0000000000005105"&gt;&amp;#x27E8;10.1097/CCM.0000000000005105&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Critical Care Medicine, 2021, 49 (9), pp.e870-e873. &amp;#x27E8;10.1097/CCM.0000000000005105&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="CHU-CLERMONTFERRAND">CHU DE CLERMONT FERRAND</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="TIMC-TREE" corresp="TIMC-IMAG">TrEE : Translational microbial Evolution and Engineering</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Samuel</forename>
                    <surname>Bersinger</surname>
                  </persName>
                  <idno type="halauthorid">3066496-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kevin</forename>
                    <surname>Lagarde</surname>
                  </persName>
                  <idno type="halauthorid">2033710-0</idno>
                  <affiliation ref="#struct-223805"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphael</forename>
                    <surname>Marlu</surname>
                  </persName>
                  <idno type="halauthorid">2453309-0</idno>
                  <affiliation ref="#struct-1082521"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gilles</forename>
                    <surname>Pernod</surname>
                  </persName>
                  <email type="md5">4016f65f8ef2b07d7ce677d2b9f73ccb</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1367614</idno>
                  <idno type="halauthorid" notation="string">250940-1367614</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6494-5984</idno>
                  <affiliation ref="#struct-1090177"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Payen</surname>
                  </persName>
                  <email type="md5">0f8191dfd45e467a78b1f4954cfcd37a</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="numeric">1477106</idno>
                  <idno type="halauthorid" notation="string">395954-1477106</idno>
                  <affiliation ref="#struct-257328"/>
                  <affiliation ref="#struct-1042703"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12171</idno>
                <idno type="issn">0090-3493</idno>
                <idno type="eissn">1530-0293</idno>
                <title level="j">Critical Care Medicine</title>
                <imprint>
                  <publisher>Lippincott, Williams &amp; Wilkins</publisher>
                  <biblScope unit="volume">49</biblScope>
                  <biblScope unit="issue">9</biblScope>
                  <biblScope unit="pp">e870-e873</biblScope>
                  <date type="datePub">2021-06-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1097/CCM.0000000000005105</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>OBJECTIVES: To describe the successful recovery from multiple and life-threatening venous thrombosis after ChAdOx1 nCoV-19 vaccination. DESIGN: Case report. SETTING: University Hospital. Patient: Few days after the first dose of the ChAdOx1 nCoV-19 vaccine, a 21-year-old woman experienced massive thrombosis in the deep and superficial cerebral veins together with seizures, neurologic focal deficit, and thrombocytopenia. In the neurointensive care unit, her condition worsened despite early decompressive craniectomy. She developed bilateral segmental pulmonary embolism, left hepatic, and left external iliac venous thrombosis. INTERVENTION: Argatroban (0.5–2.2 µg/kg/min) and high-dose IV immunoglobulin (1 g/kg/d for 2 consecutive days) were initiated on day 6 after admission. With these therapies, there was a gradual resolution of multiple sites of venous thrombosis, and platelet count returned to normal. The patient left the ICU with full consciousness, expressive aphasia, and right hemiparesis. CONCLUSIONS: This case of vaccine-induced immune thrombotic thrombocytopenia shows that a good outcome can be obtained even with multiple and life-threatening venous thrombotic lesions. Argatroban and high-dose IV immunoglobulin along with management of severe cerebral venous thrombosis played a major role in this epilogue.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-223805" status="VALID">
          <orgName>Service Anésthésie et Réanimation [CHU Clermont-Ferrand]</orgName>
          <desc>
            <address>
              <addrLine>CHU Clermont-Ferrand - Site Estaing, 1 Rue Lucie et Raymond Aubrac, 63100 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/liste-services/anesthesie-et-reanimation</ref>
          </desc>
          <listRelation>
            <relation active="#struct-380171" type="direct"/>
            <relation active="#struct-300144" type="indirect"/>
            <relation active="#struct-1082777" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1082521" status="VALID">
          <orgName>Centre de référence national des angiœdèmes</orgName>
          <orgName type="acronym">CREAK</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>CHU Nord de Grenoble - Albert Michallon, Médecine interne Boulevard de la Chantourne 38043 Grenoble CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/content/centre-national-de-reference-des-angioedemes-creak</ref>
          </desc>
          <listRelation>
            <relation active="#struct-257328" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1090177" status="VALID">
          <orgName>Investigation Network Initiative - Cardiovascular and Rénal Clinical Trialist</orgName>
          <orgName type="acronym">INI-CRCT</orgName>
          <date type="start">2014-01-01</date>
          <desc>
            <address>
              <addrLine>4 Rue du Morvan, 54500 Vandœuvre-lès-Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://inicrct.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-380171" status="VALID">
          <orgName>CHU Estaing [Clermont-Ferrand]</orgName>
          <desc>
            <address>
              <addrLine>1 Rue Lucie et Raymond Aubrac, 63100 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/les-sites/site-estaing</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300144" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300144" status="VALID">
          <idno type="IdRef">026606836</idno>
          <idno type="ISNI">0000000406394151</idno>
          <idno type="ROR">https://ror.org/02tcf7a68</idno>
          <orgName>CHU Clermont-Ferrand</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1082777" status="VALID">
          <orgName>Pôle Médecine Péri-opératoire [CHU Clermont-Ferrand]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/liste-poles/pole-medecine-peri-operatoire</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300144" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>