<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04820265</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T14:13:07+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability?</title>
            <author role="crp">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Champigneulle</surname>
              </persName>
              <email type="md5">bcdcb859ba4a06ed8b000eae47047bfe</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1170617</idno>
              <idno type="halauthorid" notation="string">740906-1170617</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0922-5102</idno>
              <idno type="IDREF">https://www.idref.fr/231404549</idno>
              <idno type="VIAF">https://viaf.org/viaf/136154440094035340679</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Caton</surname>
              </persName>
              <email type="md5">640241e37e43f0c4ff148ff6eac31ea5</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">francois-caton</idno>
              <idno type="idhal" notation="numeric">1439240</idno>
              <idno type="halauthorid" notation="string">366515-1439240</idno>
              <affiliation ref="#struct-1043300"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Landry</forename>
                <surname>Seyve</surname>
              </persName>
              <idno type="halauthorid">1275782-0</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Émeric</forename>
                <surname>Stauffer</surname>
              </persName>
              <idno type="idhal" notation="numeric">1269406</idno>
              <idno type="halauthorid" notation="string">2859251-1269406</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7987-2252</idno>
              <idno type="IDREF">https://www.idref.fr/177964766</idno>
              <affiliation ref="#struct-194495"/>
              <affiliation ref="#struct-93721"/>
              <affiliation ref="#struct-1005049"/>
              <affiliation ref="#struct-456899"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurélien</forename>
                <surname>Pichon</surname>
              </persName>
              <email type="md5">36f218326bf6ce4cc178705fe10a9218</email>
              <email type="domain">univ-poitiers.fr</email>
              <ptr type="url" target="https://www.adscientificindex.com/scientist/aurelien-pichon/1708870"/>
              <idno type="idhal" notation="string">aurelien-pichon</idno>
              <idno type="idhal" notation="numeric">1416831</idno>
              <idno type="halauthorid" notation="string">719262-1416831</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2772-9232</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=vZNQEu8AAAAJ</idno>
              <idno type="IDREF">https://www.idref.fr/076950905</idno>
              <idno type="VIAF">https://viaf.org/viaf/192777799</idno>
              <idno type="ISNI">http://isni.org/isni/0000000139641188</idno>
              <affiliation ref="#struct-1083602"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julien</forename>
                <surname>Brugniaux</surname>
              </persName>
              <email type="md5">f15a34dab81c0d38fede132547359f4a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">julien-brugniaux</idno>
              <idno type="idhal" notation="numeric">1269422</idno>
              <idno type="halauthorid" notation="string">2474488-1269422</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8076-9861</idno>
              <idno type="IDREF">https://www.idref.fr/103774130</idno>
              <idno type="VIAF">https://viaf.org/viaf/203246024</idno>
              <idno type="ISNI">http://isni.org/isni/0000000358160720</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Furian</surname>
              </persName>
              <idno type="idhal" notation="numeric">1269407</idno>
              <idno type="halauthorid" notation="string">2599953-1269407</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8518-5029</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ivan</forename>
                <surname>Hancco</surname>
              </persName>
              <idno type="halauthorid">1990052-0</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Blandine</forename>
                <surname>Deschamps</surname>
              </persName>
              <idno type="halauthorid">3091305-0</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lars</forename>
                <surname>Kaestner</surname>
              </persName>
              <idno type="halauthorid">805917-0</idno>
              <affiliation ref="#struct-335335"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul</forename>
                <surname>Robach</surname>
              </persName>
              <idno type="halauthorid">452290-0</idno>
              <affiliation ref="#struct-552360"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Connes</surname>
              </persName>
              <email type="md5">e68ea10fb1e082225142cbb84b66371c</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="string">philippe-connes</idno>
              <idno type="idhal" notation="numeric">21432</idno>
              <idno type="halauthorid" notation="string">5710-21432</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9232-0268</idno>
              <idno type="IDREF">https://www.idref.fr/078458781</idno>
              <idno type="VIAF">https://viaf.org/viaf/126915384</idno>
              <idno type="ISNI">http://isni.org/isni/0000000087442733</idno>
              <affiliation ref="#struct-1005049"/>
              <affiliation ref="#struct-93721"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Bouzat</surname>
              </persName>
              <email type="md5">0c2095aef31ac0ba391d2193535e7ee2</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="string">pierre-bouzat</idno>
              <idno type="idhal" notation="numeric">917326</idno>
              <idno type="halauthorid" notation="string">402337-917326</idno>
              <affiliation ref="#struct-1042703"/>
              <affiliation ref="#struct-408885"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Polack</surname>
              </persName>
              <email type="md5">57561dd4fe217a1caf2697ee917e4754</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">839736</idno>
              <idno type="halauthorid" notation="string">204413-839736</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1697-6249</idno>
              <idno type="IDREF">https://www.idref.fr/059672048</idno>
              <idno type="VIAF">https://viaf.org/viaf/201988847</idno>
              <idno type="ISNI">http://isni.org/isni/0000000357994889</idno>
              <affiliation ref="#struct-1043049"/>
              <affiliation ref="#struct-257328"/>
              <affiliation ref="#struct-1069752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphael</forename>
                <surname>Marlu</surname>
              </persName>
              <idno type="idhal" notation="numeric">1252486</idno>
              <idno type="halauthorid" notation="string">2453309-1252486</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3462-2006</idno>
              <affiliation ref="#struct-257328"/>
              <affiliation ref="#struct-1043049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Samuel</forename>
                <surname>Verges</surname>
              </persName>
              <email type="md5">20da60fa8c4215ca486b589aaf20d9c9</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">919185</idno>
              <idno type="halauthorid" notation="string">612408-919185</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0831-9222</idno>
              <idno type="IDREF">https://www.idref.fr/076915204</idno>
              <idno type="ISNI">http://isni.org/isni/0000000358878281</idno>
              <idno type="VIAF">https://viaf.org/viaf/211137630</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pierre</forename>
                <surname>BOUZAT</surname>
              </persName>
              <email type="md5">0c2095aef31ac0ba391d2193535e7ee2</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
            <funder ref="#projanr-42467"/>
            <funder ref="#projanr-36201"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-12-05 10:33:23</date>
              <date type="whenModified">2026-04-23 14:50:06</date>
              <date type="whenReleased">2024-12-05 10:33:23</date>
              <date type="whenProduced">2024-03-30</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140178"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1606466">
                <persName>
                  <forename>Pierre</forename>
                  <surname>BOUZAT</surname>
                </persName>
                <email type="md5">0c2095aef31ac0ba391d2193535e7ee2</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04820265</idno>
            <idno type="halUri">https://hal.science/hal-04820265</idno>
            <idno type="halBibtex">champigneulle:hal-04820265</idno>
            <idno type="halRefHtml">&lt;i&gt;Experimental Physiology&lt;/i&gt;, 2024, 109 (6), pp.899-914. &lt;a target="_blank" href="https://dx.doi.org/10.1113/EP091670"&gt;&amp;#x27E8;10.1113/EP091670&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Experimental Physiology, 2024, 109 (6), pp.899-914. &amp;#x27E8;10.1113/EP091670&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="UNIV-SAVOIE">Université Savoie Mont Blanc</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="UNIV-POITIERS">Université de Poitiers</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="LRP" corresp="INPG">Laboratoire Rhéologie et Procédés</idno>
            <idno type="stamp" n="LIBM" corresp="UNIV-SAVOIE">Laboratoire Interuniversitaire de Biologie de la Motricité</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="MOVE-UP" corresp="COLL-STAPS">Mobilité Vieillissement et Exercice</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TIMC-TREE" corresp="TIMC-IMAG">TrEE : Translational microbial Evolution and Engineering</idno>
            <idno type="stamp" n="JO">JO et Sport ANR</idno>
            <idno type="stamp" n="GRENOBLEINSTITUTNEUROSCIENCES">Grenoble Institut Neurociences</idno>
            <idno type="stamp" n="STAPS">STAPS</idno>
            <idno type="stamp" n="COLL-STAPS">COLL-STAPS</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability?</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Champigneulle</surname>
                  </persName>
                  <email type="md5">bcdcb859ba4a06ed8b000eae47047bfe</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1170617</idno>
                  <idno type="halauthorid" notation="string">740906-1170617</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0922-5102</idno>
                  <idno type="IDREF">https://www.idref.fr/231404549</idno>
                  <idno type="VIAF">https://viaf.org/viaf/136154440094035340679</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Caton</surname>
                  </persName>
                  <email type="md5">640241e37e43f0c4ff148ff6eac31ea5</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">francois-caton</idno>
                  <idno type="idhal" notation="numeric">1439240</idno>
                  <idno type="halauthorid" notation="string">366515-1439240</idno>
                  <affiliation ref="#struct-1043300"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Landry</forename>
                    <surname>Seyve</surname>
                  </persName>
                  <idno type="halauthorid">1275782-0</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Émeric</forename>
                    <surname>Stauffer</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1269406</idno>
                  <idno type="halauthorid" notation="string">2859251-1269406</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7987-2252</idno>
                  <idno type="IDREF">https://www.idref.fr/177964766</idno>
                  <affiliation ref="#struct-194495"/>
                  <affiliation ref="#struct-93721"/>
                  <affiliation ref="#struct-1005049"/>
                  <affiliation ref="#struct-456899"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurélien</forename>
                    <surname>Pichon</surname>
                  </persName>
                  <email type="md5">36f218326bf6ce4cc178705fe10a9218</email>
                  <email type="domain">univ-poitiers.fr</email>
                  <ptr type="url" target="https://www.adscientificindex.com/scientist/aurelien-pichon/1708870"/>
                  <idno type="idhal" notation="string">aurelien-pichon</idno>
                  <idno type="idhal" notation="numeric">1416831</idno>
                  <idno type="halauthorid" notation="string">719262-1416831</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2772-9232</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=vZNQEu8AAAAJ</idno>
                  <idno type="IDREF">https://www.idref.fr/076950905</idno>
                  <idno type="VIAF">https://viaf.org/viaf/192777799</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000139641188</idno>
                  <affiliation ref="#struct-1083602"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julien</forename>
                    <surname>Brugniaux</surname>
                  </persName>
                  <email type="md5">f15a34dab81c0d38fede132547359f4a</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">julien-brugniaux</idno>
                  <idno type="idhal" notation="numeric">1269422</idno>
                  <idno type="halauthorid" notation="string">2474488-1269422</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8076-9861</idno>
                  <idno type="IDREF">https://www.idref.fr/103774130</idno>
                  <idno type="VIAF">https://viaf.org/viaf/203246024</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000358160720</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Furian</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1269407</idno>
                  <idno type="halauthorid" notation="string">2599953-1269407</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8518-5029</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ivan</forename>
                    <surname>Hancco</surname>
                  </persName>
                  <idno type="halauthorid">1990052-0</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Blandine</forename>
                    <surname>Deschamps</surname>
                  </persName>
                  <idno type="halauthorid">3091305-0</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lars</forename>
                    <surname>Kaestner</surname>
                  </persName>
                  <idno type="halauthorid">805917-0</idno>
                  <affiliation ref="#struct-335335"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul</forename>
                    <surname>Robach</surname>
                  </persName>
                  <idno type="halauthorid">452290-0</idno>
                  <affiliation ref="#struct-552360"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Connes</surname>
                  </persName>
                  <email type="md5">e68ea10fb1e082225142cbb84b66371c</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="string">philippe-connes</idno>
                  <idno type="idhal" notation="numeric">21432</idno>
                  <idno type="halauthorid" notation="string">5710-21432</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9232-0268</idno>
                  <idno type="IDREF">https://www.idref.fr/078458781</idno>
                  <idno type="VIAF">https://viaf.org/viaf/126915384</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000087442733</idno>
                  <affiliation ref="#struct-1005049"/>
                  <affiliation ref="#struct-93721"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Bouzat</surname>
                  </persName>
                  <email type="md5">0c2095aef31ac0ba391d2193535e7ee2</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="string">pierre-bouzat</idno>
                  <idno type="idhal" notation="numeric">917326</idno>
                  <idno type="halauthorid" notation="string">402337-917326</idno>
                  <affiliation ref="#struct-1042703"/>
                  <affiliation ref="#struct-408885"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Polack</surname>
                  </persName>
                  <email type="md5">57561dd4fe217a1caf2697ee917e4754</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">839736</idno>
                  <idno type="halauthorid" notation="string">204413-839736</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1697-6249</idno>
                  <idno type="IDREF">https://www.idref.fr/059672048</idno>
                  <idno type="VIAF">https://viaf.org/viaf/201988847</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000357994889</idno>
                  <affiliation ref="#struct-1043049"/>
                  <affiliation ref="#struct-257328"/>
                  <affiliation ref="#struct-1069752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphael</forename>
                    <surname>Marlu</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1252486</idno>
                  <idno type="halauthorid" notation="string">2453309-1252486</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3462-2006</idno>
                  <affiliation ref="#struct-257328"/>
                  <affiliation ref="#struct-1043049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Samuel</forename>
                    <surname>Verges</surname>
                  </persName>
                  <email type="md5">20da60fa8c4215ca486b589aaf20d9c9</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">919185</idno>
                  <idno type="halauthorid" notation="string">612408-919185</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0831-9222</idno>
                  <idno type="IDREF">https://www.idref.fr/076915204</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000358878281</idno>
                  <idno type="VIAF">https://viaf.org/viaf/211137630</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-257328"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13203</idno>
                <idno type="issn">0958-0670</idno>
                <idno type="eissn">1469-445X</idno>
                <title level="j">Experimental Physiology</title>
                <imprint>
                  <publisher>Wiley-Blackwell</publisher>
                  <biblScope unit="volume">109</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">899-914</biblScope>
                  <date type="datePub">2024-03-30</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1113/EP091670</idno>
              <idno type="pubmed">38554124</idno>
              <idno type="pubmedcentral">PMC11140178</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">excessive erythrocytosis</term>
                <term xml:lang="en">blood coagulation</term>
                <term xml:lang="en">chronic mountain sickness</term>
                <term xml:lang="en">thromboelastometry</term>
                <term xml:lang="en">hypoxia</term>
              </keywords>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Altitude Sickness / blood</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Hematocrit / methods</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Peru</classCode>
              <classCode scheme="mesh">Polycythemia* / blood</classCode>
              <classCode scheme="mesh">Thrombelastography* / methods</classCode>
              <classCode scheme="mesh">Thrombin / metabolism</classCode>
              <classCode scheme="mesh">Thrombophilia* / blood</classCode>
              <classCode scheme="mesh">Altitude Sickness / physiopathology</classCode>
              <classCode scheme="mesh">Altitude*</classCode>
              <classCode scheme="mesh">Blood Coagulation* / physiology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Chronic mountain sickness is a maladaptive syndrome that affects individuals living permanently at high altitude and is characterized primarily by excessive erythrocytosis (EE). Recent results concerning the impact of EE in Andean highlanders on clotting and the possible promotion of hypercoagulability, which can lead to thrombosis, were contradictory. We assessed the coagulation profiles of Andeans highlanders with and without excessive erythrocytosis (EE+ and EE−). Blood samples were collected from 30 EE+ and 15 EE− in La Rinconada (Peru, 5100–5300 m a.s.l.), with special attention given to the sampling pre‐analytical variables. Rotational thromboelastometry tests were performed at both native and normalized (40%) haematocrit using autologous platelet‐poor plasma. Thrombin generation, dosages of clotting factors and inhibitors were measured in plasma samples. Data were compared between groups and with measurements performed at native haematocrit in 10 lowlanders (LL) at sea level. At native haematocrit, in all rotational thromboelastometry assays, EE+ exhibited hypocoagulable profiles (prolonged clotting time and weaker clot strength) compared with EE− and LL (all P &amp;lt; 0.01). At normalized haematocrit, clotting times were normalized in most individuals. Conversely, maximal clot firmness was normalized only in FIBTEM and not in EXTEM/INTEM assays, suggesting abnormal platelet activity. Thrombin generation, levels of plasma clotting factors and inhibitors, and standard coagulation assays were mostly normal in all groups. No highlanders reported a history of venous thromboembolism based on the dedicated survey. Collectively, these results indicate that EE+ do not present a hypercoagulable profile potentially favouring thrombosis.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1079233" status="VALID">
          <idno type="IdRef">18493902X</idno>
          <idno type="RNSR">201119418N</idno>
          <orgName>Hypoxie et PhysioPathologie</orgName>
          <orgName type="acronym">HP2</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Facultés de médecine et de pharmacie Domaine de la merci 38706 LA TRONCHE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hp2.univ-grenoble-alpes.fr/accueil</ref>
          </desc>
          <listRelation>
            <relation name="U1042" active="#struct-303623" type="direct"/>
            <relation name="EA3745 / ERI17" active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1043300" status="VALID">
          <idno type="IdRef">184670020</idno>
          <idno type="RNSR">199511964F</idno>
          <idno type="ROR">https://ror.org/044ggyg50</idno>
          <orgName>Laboratoire Rhéologie et Procédés</orgName>
          <orgName type="acronym">LRP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>363 rue de la Chimie BP 53 38041 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.laboratoire-rheologie-et-procedes.fr</ref>
          </desc>
          <listRelation>
            <relation name="UMR5520" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-93721" status="VALID">
          <idno type="IdRef">185116175</idno>
          <idno type="RNSR">201622148J</idno>
          <idno type="ROR">https://ror.org/03sc1p174</idno>
          <orgName>Laboratoire Interuniversitaire de Biologie de la Motricité</orgName>
          <orgName type="acronym">LIBM</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecin Campus Santé Innovations - Bâtiment IRMIS - 10 rue de la Marandière 42270 Saint Priest en JarezUniversité Savoie Mont Blanc - Campus Scientifique - 73370 Le Bourget du LacUFR STAPS - Université Claude Bernard Lyon I - 27/29 Boulevard du 11 novembre 1918 - 69622 Villeurbanne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://libm.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation name="EA7424" active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="EA7424" active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="EA7424" active="#struct-432896" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1005049" status="VALID">
          <orgName>Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge</orgName>
          <orgName type="acronym">Labex Gr-Ex</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Imagine Institute24, Boulevard du Montparnasse75015, Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.labex-grex.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303171" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-456899" status="VALID">
          <idno type="ROR">https://ror.org/006evg656</idno>
          <orgName>Hôpital de la Croix-Rousse [CHU - HCL]</orgName>
          <desc>
            <address>
              <addrLine>103 Grande Rue de la Croix-Rousse69004 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hopital-de-la-croix-rousse</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1083602" status="VALID">
          <idno type="IdRef">164806210</idno>
          <idno type="RNSR">201220296N</idno>
          <idno type="Wikidata">Q51780851</idno>
          <orgName>Laboratoire Mobilité, Vieillissement, Exercice [UR 20296]</orgName>
          <orgName type="acronym">MOVE [Poitiers]</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Poitiers – Bâtiment C6 – 8 allée Jean Monnet – TSA 31113 – 86073 Poitiers Cedex 9 – France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://move.labo.univ-poitiers.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UR20296" active="#struct-54493" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-335335" status="VALID">
          <orgName>University of Saarland / Universität des Saarlandes [Homburg, Germany]</orgName>
          <desc>
            <address>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uni-saarland.de/start.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-552360" status="VALID">
          <idno type="ISNI">0000000508290513</idno>
          <idno type="Wikidata">Q3020567</idno>
          <orgName>École nationale des sports de montagne</orgName>
          <orgName type="acronym">ENSM</orgName>
          <date type="start">2010-11-12</date>
          <desc>
            <address>
              <addrLine>35 route du Bouchet – 74400 Chamonix-Mont-Blanc – France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ensm.sports.gouv.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-408885" status="VALID">
          <idno type="IdRef">184664446</idno>
          <idno type="ISNI">0000000404293736</idno>
          <idno type="RNSR">200716488W</idno>
          <idno type="ROR">https://ror.org/04as3rk94</idno>
          <orgName>[GIN] Grenoble Institut des Neurosciences</orgName>
          <orgName type="acronym">GIN</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Site Santé - Bâtiment Edmond J. Safra - Chemin Fortuné Ferrini 38706 La Tronche Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://neurosciences.univ-grenoble-alpes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1216" active="#struct-303623" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1069752" status="VALID">
          <orgName>Translational microbial Evolution and Engineering</orgName>
          <orgName type="acronym">TIMC-TrEE</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine de Grenoble, bâtiment Jean Roget, 38706 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/TrEE</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300284" status="VALID">
          <idno type="IdRef">028209966</idno>
          <idno type="ISNI">0000 0001 2158 1682</idno>
          <idno type="ROR">https://ror.org/04yznqr36</idno>
          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
          <date type="start">1969-03-27</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-432896" status="VALID">
          <idno type="ROR">https://ror.org/04gqg1a07</idno>
          <orgName>Université Savoie Mont Blanc</orgName>
          <orgName type="acronym">USMB [Université de Savoie] [Université de Chambéry]</orgName>
          <date type="start">1979-10-01</date>
          <desc>
            <address>
              <addrLine>27, rue Marcoz - 73000 Chambéry</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-smb.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-303171" status="VALID">
          <idno type="IdRef">19077990X</idno>
          <idno type="ROR">https://ror.org/001z21q04</idno>
          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-54493" status="VALID">
          <idno type="IdRef">026403765</idno>
          <idno type="ISNI">0000000121606368</idno>
          <idno type="ROR">https://ror.org/04xhy8q59</idno>
          <idno type="Wikidata">Q661056</idno>
          <orgName>Université de Poitiers =  University of Poitiers</orgName>
          <orgName type="acronym">UP</orgName>
          <desc>
            <address>
              <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-poitiers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-42467" status="VALID">
          <idno type="anr">ANR-15-IDEX-0002</idno>
          <orgName>UGA</orgName>
          <desc>IDEX UGA</desc>
          <date type="start">2015</date>
        </org>
        <org type="anrProject" xml:id="projanr-36201" status="VALID">
          <idno type="anr">ANR-12-TECS-0010</idno>
          <idno type="program">Technologie pour la santé et l'autonomie</idno>
          <orgName>PASITHEA</orgName>
          <desc>Traitement personnalisé et adaptatif par stimulation kinesthésique pour les syndromes d'apnée du sommeil, basé sur un moniteur Holter cardio-respiratoire</desc>
          <date type="start">2012</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>