<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04814446</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T12:42:42+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Clinical, economic and organizational impact of pharmacist interventions on injectable antineoplastic prescriptions: a prospective observational study</title>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Zecchini</surname>
              </persName>
              <idno type="idhal" notation="numeric">1452992</idno>
              <idno type="halauthorid" notation="string">1516113-1452992</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4318-9160</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thi-Ha</forename>
                <surname>Vo</surname>
              </persName>
              <idno type="halauthorid">1424005-0</idno>
              <affiliation ref="#struct-257328"/>
              <affiliation ref="#struct-1070489"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Chanoine</surname>
              </persName>
              <idno type="idhal" notation="numeric">1531424</idno>
              <idno type="halauthorid" notation="string">1334478-1531424</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7708-9777</idno>
              <idno type="IDREF">https://www.idref.fr/166402532</idno>
              <idno type="VIAF">https://viaf.org/viaf/313308315</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/S-1326-2017</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CJW-2351-2022</idno>
              <affiliation ref="#struct-1070489"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marion</forename>
                <surname>Lepelley</surname>
              </persName>
              <idno type="halauthorid">714473-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mathieu</forename>
                <surname>Laramas</surname>
              </persName>
              <idno type="halauthorid">353656-0</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aude</forename>
                <surname>Lemoigne</surname>
              </persName>
              <idno type="halauthorid">1214142-0</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoît</forename>
                <surname>Allenet</surname>
              </persName>
              <email type="md5">762a7331d13b00d4192b9fd11ac15ba4</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1449882</idno>
              <idno type="halauthorid" notation="string">723204-1449882</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9989-5101</idno>
              <idno type="IDREF">https://www.idref.fr/067288529</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5928-2014</idno>
              <idno type="VIAF">https://viaf.org/viaf/173040404</idno>
              <idno type="ISNI">http://isni.org/isni/0000000123308671</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=MpAC050AAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/132146094178400330966</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-5928-2014</idno>
              <affiliation ref="#struct-1070501"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Federspiel</surname>
              </persName>
              <idno type="halauthorid">3320440-0</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierrick</forename>
                <surname>Bedouch</surname>
              </persName>
              <email type="md5">df87b984e786efcad038fbcca99ee653</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="string">pierrickbedouch</idno>
              <idno type="idhal" notation="numeric">774510</idno>
              <idno type="halauthorid" notation="string">384548-774510</idno>
              <idno type="IDREF">https://www.idref.fr/067288758</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2245-0160</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=MbXsEckAAAAJ</idno>
              <idno type="ISNI">http://isni.org/isni/0000000123687368</idno>
              <idno type="VIAF">https://viaf.org/viaf/173641003</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6169-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/MGW-7580-2025</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6169-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/MGW-7580-2025</idno>
              <affiliation ref="#struct-1070501"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pierrick</forename>
                <surname>Bedouch</surname>
              </persName>
              <email type="md5">df87b984e786efcad038fbcca99ee653</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-01-06 10:17:39</date>
              <date type="whenModified">2026-03-26 16:30:05</date>
              <date type="whenReleased">2025-01-10 15:12:16</date>
              <date type="whenProduced">2020-02-12</date>
              <date type="whenEndEmbargoed">2025-01-06</date>
              <ref type="file" target="https://hal.science/hal-04814446v1/document">
                <date notBefore="2025-01-06"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-04814446v1/file/s12913-020-4963-7.pdf" id="file-4865673-4242352">
                <date notBefore="2025-01-06"/>
              </ref>
              <ref type="externalLink" target="https://bmchealthservres.biomedcentral.com/track/pdf/10.1186/s12913-020-4963-7"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="128884">
                <persName>
                  <forename>Pierrick</forename>
                  <surname>Bedouch</surname>
                </persName>
                <email type="md5">df87b984e786efcad038fbcca99ee653</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04814446</idno>
            <idno type="halUri">https://hal.science/hal-04814446</idno>
            <idno type="halBibtex">zecchini:hal-04814446</idno>
            <idno type="halRefHtml">&lt;i&gt;BMC Health Services Research&lt;/i&gt;, 2020, 20 (1), pp.113. &lt;a target="_blank" href="https://dx.doi.org/10.1186/s12913-020-4963-7"&gt;&amp;#x27E8;10.1186/s12913-020-4963-7&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">BMC Health Services Research, 2020, 20 (1), pp.113. &amp;#x27E8;10.1186/s12913-020-4963-7&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4865673-4242352"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SHS">Sciences de l'Homme et de la Société</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEMAS" corresp="TIMC-IMAG">ThEMAS : Techniques pour l'Evaluation et la Modélisation des Actions de Santé</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Clinical, economic and organizational impact of pharmacist interventions on injectable antineoplastic prescriptions: a prospective observational study</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Zecchini</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1452992</idno>
                  <idno type="halauthorid" notation="string">1516113-1452992</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4318-9160</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thi-Ha</forename>
                    <surname>Vo</surname>
                  </persName>
                  <idno type="halauthorid">1424005-0</idno>
                  <affiliation ref="#struct-257328"/>
                  <affiliation ref="#struct-1070489"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Chanoine</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1531424</idno>
                  <idno type="halauthorid" notation="string">1334478-1531424</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7708-9777</idno>
                  <idno type="IDREF">https://www.idref.fr/166402532</idno>
                  <idno type="VIAF">https://viaf.org/viaf/313308315</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/S-1326-2017</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CJW-2351-2022</idno>
                  <affiliation ref="#struct-1070489"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marion</forename>
                    <surname>Lepelley</surname>
                  </persName>
                  <idno type="halauthorid">714473-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mathieu</forename>
                    <surname>Laramas</surname>
                  </persName>
                  <idno type="halauthorid">353656-0</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aude</forename>
                    <surname>Lemoigne</surname>
                  </persName>
                  <idno type="halauthorid">1214142-0</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoît</forename>
                    <surname>Allenet</surname>
                  </persName>
                  <email type="md5">762a7331d13b00d4192b9fd11ac15ba4</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1449882</idno>
                  <idno type="halauthorid" notation="string">723204-1449882</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9989-5101</idno>
                  <idno type="IDREF">https://www.idref.fr/067288529</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5928-2014</idno>
                  <idno type="VIAF">https://viaf.org/viaf/173040404</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000123308671</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=MpAC050AAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/132146094178400330966</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-5928-2014</idno>
                  <affiliation ref="#struct-1070501"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Federspiel</surname>
                  </persName>
                  <idno type="halauthorid">3320440-0</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierrick</forename>
                    <surname>Bedouch</surname>
                  </persName>
                  <email type="md5">df87b984e786efcad038fbcca99ee653</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="string">pierrickbedouch</idno>
                  <idno type="idhal" notation="numeric">774510</idno>
                  <idno type="halauthorid" notation="string">384548-774510</idno>
                  <idno type="IDREF">https://www.idref.fr/067288758</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2245-0160</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=MbXsEckAAAAJ</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000123687368</idno>
                  <idno type="VIAF">https://viaf.org/viaf/173641003</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6169-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/MGW-7580-2025</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6169-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/MGW-7580-2025</idno>
                  <affiliation ref="#struct-1070501"/>
                  <affiliation ref="#struct-257328"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">335</idno>
                <idno type="issn">1472-6963</idno>
                <title level="j">BMC Health Services Research</title>
                <imprint>
                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">20</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">113</biblScope>
                  <date type="datePub">2020-02-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/s12913-020-4963-7</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="shs">Humanities and Social Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Abstract Background Pharmacists play a key role in ensuring the safe use of injectable antineoplastics, which are considered as high-alert medications. Pharmaceutical analysis of injectable antineoplastic prescriptions aims to detect and prevent drug related problems by proposing pharmacist interventions (PI). The impact of this activity for patients, healthcare facilities and other health professionals is not completely known. This study aimed at describing the clinical, economic, and organizational impacts of PIs performed by pharmacists in a chemotherapy preparation unit. Methods A prospective 10-week study was conducted on PIs involving injectable antineoplastic prescriptions. Each PI was assessed by one of the four multidisciplinary expert committees using a multidimensional tool with three independent dimensions: clinical, economic and organizational. An ancillary quantitative evaluation of drug cost savings was conducted. Results Overall, 185 patients were included (mean age: 63.5 ± 13.7 years; 54.1% were male) and 237 PIs concerning 10.1% prescriptions were recorded. Twenty one PIs (8.9%) had major clinical impact (ie: prevented hospitalization or permanent disability), 49 PIs (20.7%) had moderate clinical impact (ie: prevented harm that would have required further monitoring/treatment), 62 PIs (26.2%) had minor clinical impact, 95 PIs (40.0%) had no clinical impact, and 9 PIs (3.8%) had a negative clinical impact. For one PI (0.4%) the clinical impact was not determined due to insufficient information. Regarding organizational impact, 67.5% PIs had a positive impact on patient management from the healthcare providers’ perspective. A positive economic impact was observed for 105 PIs (44.3%), leading to a saving in direct drug costs of 15,096 €; 38 PIs (16.0%) had a negative economic impact, increasing the direct drug cost by 11,878 €. Overall cost saving was 3218€. Conclusions PIs are associated with positive clinical, economic and organizational impacts. This study confirms the benefit of pharmacist analysis of injectable antineoplastic prescriptions for patient safety with an overall benefit to the healthcare system.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1070489" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1070501" status="OLD">
          <orgName>Techniques pour l'Evaluation et la Modélisation des Actions de la Santé</orgName>
          <orgName type="acronym">TIMC-IMAG-ThEMAS</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/ThEMAS</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1070489" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>