<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04805063</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T23:17:13+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Change in out-of-hospital 12-lead ECG diagnostic classification following resuscitation from cardiac arrest</title>
            <author role="aut">
              <persName>
                <forename type="first">Tom</forename>
                <surname>Aufderheide</surname>
              </persName>
              <idno type="halauthorid">1547283-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Engel</surname>
              </persName>
              <idno type="halauthorid">429383-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hadi</forename>
                <surname>Saleh</surname>
              </persName>
              <idno type="halauthorid">3314272-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Gutterman</surname>
              </persName>
              <idno type="halauthorid">2245983-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <surname>Weston</surname>
              </persName>
              <idno type="halauthorid">3314273-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul</forename>
                <surname>Pepe</surname>
              </persName>
              <idno type="halauthorid">1547264-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">John</forename>
                <surname>Baker</surname>
              </persName>
              <idno type="halauthorid">658132-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jacob</forename>
                <surname>Labinski</surname>
              </persName>
              <idno type="halauthorid">3314274-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Debaty</surname>
              </persName>
              <email type="md5">f71ae0776d3c41e08dfa77e6ccda38ce</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="string">guillaume-debaty</idno>
              <idno type="idhal" notation="numeric">172126</idno>
              <idno type="halauthorid" notation="string">8951-172126</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2879-0326</idno>
              <idno type="IDREF">https://www.idref.fr/069172633</idno>
              <affiliation ref="#struct-1043057"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lujia</forename>
                <surname>Tang</surname>
              </persName>
              <idno type="halauthorid">3314275-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aniko</forename>
                <surname>Szabo</surname>
              </persName>
              <idno type="halauthorid">3314276-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rajat</forename>
                <surname>Kalra</surname>
              </persName>
              <idno type="halauthorid">3122893-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Demetris</forename>
                <surname>Yannopoulos</surname>
              </persName>
              <idno type="halauthorid">1546475-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M. Riccardo</forename>
                <surname>Colella</surname>
              </persName>
              <idno type="halauthorid">3314277-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Stéphane</forename>
                <surname>Tanguy</surname>
              </persName>
              <email type="md5">41484c13f4ce797604ec0b29e1ff2520</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-11-26 15:02:01</date>
              <date type="whenModified">2025-09-27 19:58:59</date>
              <date type="whenReleased">2024-11-26 15:02:01</date>
              <date type="whenProduced">2021-12</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="171555">
                <persName>
                  <forename>Stéphane</forename>
                  <surname>Tanguy</surname>
                </persName>
                <email type="md5">41484c13f4ce797604ec0b29e1ff2520</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04805063</idno>
            <idno type="halUri">https://hal.science/hal-04805063</idno>
            <idno type="halBibtex">aufderheide:hal-04805063</idno>
            <idno type="halRefHtml">&lt;i&gt;Resuscitation&lt;/i&gt;, 2021, 169 (20), pp.45-52. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.resuscitation.2021.10.012"&gt;&amp;#x27E8;10.1016/j.resuscitation.2021.10.012&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Resuscitation, 2021, 169 (20), pp.45-52. &amp;#x27E8;10.1016/j.resuscitation.2021.10.012&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-PRETA" corresp="TIMC-IMAG">PRETA : Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Change in out-of-hospital 12-lead ECG diagnostic classification following resuscitation from cardiac arrest</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Tom</forename>
                    <surname>Aufderheide</surname>
                  </persName>
                  <idno type="halauthorid">1547283-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Engel</surname>
                  </persName>
                  <idno type="halauthorid">429383-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hadi</forename>
                    <surname>Saleh</surname>
                  </persName>
                  <idno type="halauthorid">3314272-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Gutterman</surname>
                  </persName>
                  <idno type="halauthorid">2245983-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <surname>Weston</surname>
                  </persName>
                  <idno type="halauthorid">3314273-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul</forename>
                    <surname>Pepe</surname>
                  </persName>
                  <idno type="halauthorid">1547264-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">John</forename>
                    <surname>Baker</surname>
                  </persName>
                  <idno type="halauthorid">658132-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jacob</forename>
                    <surname>Labinski</surname>
                  </persName>
                  <idno type="halauthorid">3314274-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Debaty</surname>
                  </persName>
                  <email type="md5">f71ae0776d3c41e08dfa77e6ccda38ce</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="string">guillaume-debaty</idno>
                  <idno type="idhal" notation="numeric">172126</idno>
                  <idno type="halauthorid" notation="string">8951-172126</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2879-0326</idno>
                  <idno type="IDREF">https://www.idref.fr/069172633</idno>
                  <affiliation ref="#struct-1043057"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lujia</forename>
                    <surname>Tang</surname>
                  </persName>
                  <idno type="halauthorid">3314275-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aniko</forename>
                    <surname>Szabo</surname>
                  </persName>
                  <idno type="halauthorid">3314276-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rajat</forename>
                    <surname>Kalra</surname>
                  </persName>
                  <idno type="halauthorid">3122893-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Demetris</forename>
                    <surname>Yannopoulos</surname>
                  </persName>
                  <idno type="halauthorid">1546475-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M. Riccardo</forename>
                    <surname>Colella</surname>
                  </persName>
                  <idno type="halauthorid">3314277-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">18640</idno>
                <idno type="issn">0300-9572</idno>
                <title level="j">Resuscitation</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">169</biblScope>
                  <biblScope unit="issue">20</biblScope>
                  <biblScope unit="pp">45-52</biblScope>
                  <date type="datePub">2021-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.resuscitation.2021.10.012</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Adrenaline is recommended for cardiac arrest resuscitation, but its effectiveness has been questioned recently. Achieving return of spontaneous circulation (ROSC) is essential and is obtained by increasing coronary perfusion pressure (CPP) after adrenaline injection. A threshold as high as 35 mmHg of CPP may be necessary to obtain ROSC, but increasing doses of adrenaline might be harmful to the brain. Our study aimed to compare the increase in CPP with reduced doses of adrenaline to the recommended 1 mg dose in a pig model of cardiac arrest. Fifteen domestic pigs were randomized into three groups according to the adrenaline doses: 1 mg, 0.5 mg, or 0.25 mg administered every 5 min. Cardiac arrest was induced by ventricular fibrillation; after 5 min of no-flow, mechanical chest compression was resumed. The Wilcoxon test and Kruskal–Wallis exact test were used for the comparison of groups. Fisher’s exact test was used to compare categorical variables. CPP, EtCO2 level, cerebral, and tissue near-infrared spectroscopy (NIRS) were measured. CPP was significantly lower in the 0.25 mg group 90 s after the first adrenaline injection: 28.9 (21.2; 35.4) vs. 53.8 (37.8; 58.2) in the 1 mg group (p = 0.008), while there was no significant difference with 0.5 mg 39.6 (32.7; 52.5) (p = 0.056). Overall, 0.25 mg did not achieve the threshold of 35 mmHg. EtCO2 levels were higher at T12 and T14 in the 0.5 mg than in the standard group: 32 (23; 35) vs. 19 (16; 26) and 26 (20; 34) vs. 19 (12; 22) (p &amp;lt; 0.05). Cerebral and tissue NIRS did not show a significant difference between the three groups. CPP after 0.5 mg boluses of adrenaline was not significantly different from the recommended 1 mg in our model of cardiac arrest.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1043057" status="VALID">
          <orgName>Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</orgName>
          <orgName type="acronym">TIMC-PRETA</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/preta</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>