The Ayeyarwady (aka Irrawaddy) river in Myanmar is the fourth greatest river in the world in terms of sediment discharge (370 Mt/yr). Today, most of the sediment discharge (210 Mt/yr) of the river is accumulated at the delta front. Remaining sediments and sediments from other rivers like Thalween (180 Mt/yr) and Sittang (50 Mt/yr) are deposited in the Martaban depression at the south-east end of the delta. The Ayeyrwady delta, as many delta plains is expected to sink due to sediment load. We compute the subsidence rate associated to the Holocene sediment load by producing a sedimentation model and computing the isostatic effect. Cores, Sub-bottom echo-sounding Chirp profiles, dated paleo shorelines were compiled to build a regional sedimentary model since the LGM. Regarding uncertainties on sedimentation and earth's model, we have built up endmember sedimentation scenarios. We have resolved the sea level equation and calculated subsidence in the area.