Bridging Wright-Fisher and Moran models - Archive ouverte HAL
Pré-Publication, Document De Travail Année : 2024

Bridging Wright-Fisher and Moran models

Arthur Alexandre
  • Fonction : Auteur
Alia Abbara
  • Fonction : Auteur
Cecilia Fruet
  • Fonction : Auteur
Claude Loverdo
  • Fonction : Auteur
  • PersonId : 1441919
Anne-Florence Bitbol
  • Fonction : Auteur

Résumé

The Wright-Fisher model and the Moran model are both widely used in population genetics. They describe the time evolution of the frequency of an allele in a well-mixed population with fixed size. We propose a simple and tractable model which bridges the Wright-Fisher and the Moran descriptions. We assume that a fixed fraction of the population is updated at each discrete time step. In this model, we determine the fixation probability of a mutant and its average fixation and extinction times, under the diffusion approximation. We further study the associated coalescent process, which converges to Kingman's coalescent, and we calculate effective population sizes. We generalize our model, first by taking into account fluctuating updated fractions or individual lifetimes, and then by incorporating selection on the lifetime as well as on the reproductive fitness.

Dates et versions

hal-04785259 , version 1 (15-11-2024)

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Arthur Alexandre, Alia Abbara, Cecilia Fruet, Claude Loverdo, Anne-Florence Bitbol. Bridging Wright-Fisher and Moran models. 2024. ⟨hal-04785259⟩
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