Size dependent properties of Gd3+-free versus Gd3+-doped carbon dots for bioimaging application - Archive ouverte HAL
Journal Articles Scientific Reports Year : 2024

Size dependent properties of Gd3+-free versus Gd3+-doped carbon dots for bioimaging application

Abstract

Gd 3+ -free carbon dots (CDs) were synthesized by one-step solvothermal method using urea, citric acid and 3-(trifluoromethyl)aniline as precursors. Additionally, Gd 3+ -doped CDs were prepared by incorporating gadolinium chloride (Gd 3+ ions) into the synthesis. Size selection of the purified CDs was achieved through filter membranes ranging from 3 kDa to 100 kDa. The chemical composition and optical properties of the obtained samples were characterized by Energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), Dynamic Light Scattering (DLS), proton relaxation time measurements, Ultraviolet-visible (UV-vis) and fluorescence spectroscopies. A comparative analysis revealed a strong size-dependent behavior in the optical properties of both Gd 3+ -doped and Gd 3+ -free CDs. Furthermore, in vitro tests confirmed the non-cytotoxicity of Gd 3+ -doped CDs, indicating their potential applicability in biomedicine for magnetic resonance imaging (MRI) and red fluorescence based cell and tissue imaging.

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Dates and versions

hal-04781709 , version 1 (13-11-2024)

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Nazym Zhylkybayeva, Konstantin Paliienko, Anna Topchylo, Alexander Zaderko, Alain Géloën, et al.. Size dependent properties of Gd3+-free versus Gd3+-doped carbon dots for bioimaging application. Scientific Reports, 2024, 14 (1), pp.27812. ⟨10.1038/s41598-024-76500-z⟩. ⟨hal-04781709⟩
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