<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04781608</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T19:19:24+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Prediction of strain level phage–host interactions across the Escherichia genus using only genomic information</title>
            <author role="crp">
              <persName>
                <forename type="first">Baptiste</forename>
                <surname>Gaborieau</surname>
              </persName>
              <email type="md5">d7a79cc01c3e6e123169df7bbffe99b9</email>
              <email type="domain">aphp.fr</email>
              <idno type="idhal" notation="numeric">1254185</idno>
              <idno type="halauthorid" notation="string">2647493-1254185</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9586-3014</idno>
              <affiliation ref="#struct-1005021"/>
              <affiliation ref="#struct-1090797"/>
              <affiliation ref="#struct-344348"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hugo</forename>
                <surname>Vaysset</surname>
              </persName>
              <idno type="idhal" notation="numeric">1389030</idno>
              <idno type="halauthorid" notation="string">2244008-1389030</idno>
              <idno type="ORCID">https://orcid.org/0009-0007-3134-1966</idno>
              <affiliation ref="#struct-148117"/>
              <affiliation ref="#struct-1152315"/>
              <affiliation ref="#struct-541732"/>
              <affiliation ref="#struct-564132"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florian</forename>
                <surname>Tesson</surname>
              </persName>
              <idno type="idhal" notation="numeric">1389027</idno>
              <idno type="halauthorid" notation="string">2241817-1389027</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4038-1154</idno>
              <affiliation ref="#struct-1005021"/>
              <affiliation ref="#struct-1152315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Inès</forename>
                <surname>Charachon</surname>
              </persName>
              <idno type="halauthorid">3295191-0</idno>
              <affiliation ref="#struct-1005021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Dib</surname>
              </persName>
              <idno type="halauthorid">3295192-0</idno>
              <affiliation ref="#struct-1005021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Juliette</forename>
                <surname>Bernier</surname>
              </persName>
              <idno type="halauthorid">3295193-0</idno>
              <affiliation ref="#struct-1005021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tanguy</forename>
                <surname>Dequidt</surname>
              </persName>
              <idno type="halauthorid">3295194-0</idno>
              <affiliation ref="#struct-1090797"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Héloïse</forename>
                <surname>Georjon</surname>
              </persName>
              <idno type="idhal" notation="numeric">1389029</idno>
              <idno type="halauthorid" notation="string">3228485-1389029</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0694-542X</idno>
              <affiliation ref="#struct-1152315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Clermont</surname>
              </persName>
              <idno type="halauthorid">396839-0</idno>
              <affiliation ref="#struct-1005021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascal</forename>
                <surname>Hersen</surname>
              </persName>
              <email type="md5">6d321c868b24739ed38f1be1c931d52e</email>
              <email type="domain">curie.fr</email>
              <idno type="idhal" notation="string">hersen-pascal</idno>
              <idno type="idhal" notation="numeric">178483</idno>
              <idno type="halauthorid" notation="string">1120-178483</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2379-4280</idno>
              <idno type="IDREF">https://www.idref.fr/08928707X</idno>
              <affiliation ref="#struct-541732"/>
              <affiliation ref="#struct-564132"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Debarbieux</surname>
              </persName>
              <email type="md5">57d04d2b8f1e414bb238ff02e0295383</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">laurent-debarbieux</idno>
              <idno type="idhal" notation="numeric">14176</idno>
              <idno type="halauthorid" notation="string">27799-14176</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6875-5758</idno>
              <idno type="IDREF">https://www.idref.fr/075090422</idno>
              <affiliation ref="#struct-1090797"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Damien</forename>
                <surname>Ricard</surname>
              </persName>
              <idno type="idhal" notation="numeric">1254190</idno>
              <idno type="halauthorid" notation="string">442762-1254190</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1828-2299</idno>
              <affiliation ref="#struct-1005021"/>
              <affiliation ref="#struct-344348"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Erick</forename>
                <surname>Denamur</surname>
              </persName>
              <idno type="idhal" notation="numeric">763668</idno>
              <idno type="halauthorid" notation="string">396850-763668</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7860-1717</idno>
              <affiliation ref="#struct-1005021"/>
              <affiliation ref="#struct-300156"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Aude</forename>
                <surname>Bernheim</surname>
              </persName>
              <email type="md5">91fcbc4eb4f63c539afd632e26d9b633</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1064760</idno>
              <idno type="halauthorid" notation="string">619714-1064760</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0212-777X</idno>
              <idno type="IDREF">https://www.idref.fr/225256282</idno>
              <affiliation ref="#struct-1152315"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Hersen</forename>
                <surname>Pascal</surname>
              </persName>
              <email type="md5">6d321c868b24739ed38f1be1c931d52e</email>
              <email type="domain">curie.fr</email>
            </editor>
            <funder ref="#projanr-38027"/>
            <funder ref="#projanr-51024"/>
            <funder ref="#projanr-51667"/>
            <funder ref="#projeurop-736927"/>
            <funder>Several bioinformatic analyses were performed in the Core Cluster of the Institut Français de Bioinformatique (IFB) (ANR-11-INBS-0013).B.G., H.V., F.T., I.C., N.D. and A.B. were supported by the CRI Research Fellowship to A.B. from the Bettencourt Schueller Foundation, the ATIP-Avenir programme from INSERM (R21042KS/RSE22002KSA), the Emergence programme from the University of Paris-Cité (RSFVJ21IDXB6_DANA) ERC Starting Grant (PECAN 101040529) and the core funding of Institut Pasteur. E.D. was partially supported by the ‘Fondation pour la Recherche Médicale’ (Equipe FRM 2016, grant number DEQ20161136698). L.D. was partially supported by Agence Nationale de la Recherche (ANR-19-AMRB-0002 and ANR-20-CE92-0048). B.G. was partially supported by Agence Nationale de la Recherche (ANR-19-AMRB-0002).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-10-16 11:37:39</date>
              <date type="whenModified">2025-12-03 14:48:03</date>
              <date type="whenReleased">2025-10-20 12:13:41</date>
              <date type="whenProduced">2024-11</date>
              <date type="whenEndEmbargoed">2025-10-16</date>
              <ref type="file" target="https://hal.science/hal-04781608v1/document">
                <date notBefore="2025-10-16"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04781608v1/file/Gaborieau_et_al_Accepted%20Manuscript.pdf" id="file-5317514-4554813">
                <date notBefore="2025-10-16"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="106425">
                <persName>
                  <forename>Hersen</forename>
                  <surname>Pascal</surname>
                </persName>
                <email type="md5">6d321c868b24739ed38f1be1c931d52e</email>
                <email type="domain">curie.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04781608</idno>
            <idno type="halUri">https://hal.science/hal-04781608</idno>
            <idno type="halBibtex">gaborieau:hal-04781608</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature Microbiology&lt;/i&gt;, 2024, 9 (11), pp.2847-2861. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41564-024-01832-5"&gt;&amp;#x27E8;10.1038/s41564-024-01832-5&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature Microbiology, 2024, 9 (11), pp.2847-2861. &amp;#x27E8;10.1038/s41564-024-01832-5&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5317514-4554813"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="AGROPARISTECH">AgroParisTech</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="CURIE" corresp="INSERM">Institut Curie</idno>
            <idno type="stamp" n="PCC_UMR168" corresp="SORBONNE-UNIVERSITE">Laboratoire de Physique des Cellules et Cancer = Physics of Cells and Cancer [Institut Curie] </idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="IAME" corresp="UNIV-PARIS13">Infection, Anti-microbiens, Modélisation, Evolution - UMR 1137</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="INSTITUT-CURIE-PSL" corresp="PSL">Institut Curie - PSL</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="SUPRA_PHYS_CHIMIE">Physico-Chimie</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Prediction of strain level phage–host interactions across the Escherichia genus using only genomic information</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Baptiste</forename>
                    <surname>Gaborieau</surname>
                  </persName>
                  <email type="md5">d7a79cc01c3e6e123169df7bbffe99b9</email>
                  <email type="domain">aphp.fr</email>
                  <idno type="idhal" notation="numeric">1254185</idno>
                  <idno type="halauthorid" notation="string">2647493-1254185</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9586-3014</idno>
                  <affiliation ref="#struct-1005021"/>
                  <affiliation ref="#struct-1090797"/>
                  <affiliation ref="#struct-344348"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hugo</forename>
                    <surname>Vaysset</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1389030</idno>
                  <idno type="halauthorid" notation="string">2244008-1389030</idno>
                  <idno type="ORCID">https://orcid.org/0009-0007-3134-1966</idno>
                  <affiliation ref="#struct-148117"/>
                  <affiliation ref="#struct-1152315"/>
                  <affiliation ref="#struct-541732"/>
                  <affiliation ref="#struct-564132"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florian</forename>
                    <surname>Tesson</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1389027</idno>
                  <idno type="halauthorid" notation="string">2241817-1389027</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4038-1154</idno>
                  <affiliation ref="#struct-1005021"/>
                  <affiliation ref="#struct-1152315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Inès</forename>
                    <surname>Charachon</surname>
                  </persName>
                  <idno type="halauthorid">3295191-0</idno>
                  <affiliation ref="#struct-1005021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Dib</surname>
                  </persName>
                  <idno type="halauthorid">3295192-0</idno>
                  <affiliation ref="#struct-1005021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Juliette</forename>
                    <surname>Bernier</surname>
                  </persName>
                  <idno type="halauthorid">3295193-0</idno>
                  <affiliation ref="#struct-1005021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tanguy</forename>
                    <surname>Dequidt</surname>
                  </persName>
                  <idno type="halauthorid">3295194-0</idno>
                  <affiliation ref="#struct-1090797"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Héloïse</forename>
                    <surname>Georjon</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1389029</idno>
                  <idno type="halauthorid" notation="string">3228485-1389029</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0694-542X</idno>
                  <affiliation ref="#struct-1152315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Clermont</surname>
                  </persName>
                  <idno type="halauthorid">396839-0</idno>
                  <affiliation ref="#struct-1005021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascal</forename>
                    <surname>Hersen</surname>
                  </persName>
                  <email type="md5">6d321c868b24739ed38f1be1c931d52e</email>
                  <email type="domain">curie.fr</email>
                  <idno type="idhal" notation="string">hersen-pascal</idno>
                  <idno type="idhal" notation="numeric">178483</idno>
                  <idno type="halauthorid" notation="string">1120-178483</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2379-4280</idno>
                  <idno type="IDREF">https://www.idref.fr/08928707X</idno>
                  <affiliation ref="#struct-541732"/>
                  <affiliation ref="#struct-564132"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Debarbieux</surname>
                  </persName>
                  <email type="md5">57d04d2b8f1e414bb238ff02e0295383</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">laurent-debarbieux</idno>
                  <idno type="idhal" notation="numeric">14176</idno>
                  <idno type="halauthorid" notation="string">27799-14176</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6875-5758</idno>
                  <idno type="IDREF">https://www.idref.fr/075090422</idno>
                  <affiliation ref="#struct-1090797"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Damien</forename>
                    <surname>Ricard</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1254190</idno>
                  <idno type="halauthorid" notation="string">442762-1254190</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1828-2299</idno>
                  <affiliation ref="#struct-1005021"/>
                  <affiliation ref="#struct-344348"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Erick</forename>
                    <surname>Denamur</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">763668</idno>
                  <idno type="halauthorid" notation="string">396850-763668</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7860-1717</idno>
                  <affiliation ref="#struct-1005021"/>
                  <affiliation ref="#struct-300156"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Aude</forename>
                    <surname>Bernheim</surname>
                  </persName>
                  <email type="md5">91fcbc4eb4f63c539afd632e26d9b633</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1064760</idno>
                  <idno type="halauthorid" notation="string">619714-1064760</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0212-777X</idno>
                  <idno type="IDREF">https://www.idref.fr/225256282</idno>
                  <affiliation ref="#struct-1152315"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">107229</idno>
                <idno type="issn">2058-5276</idno>
                <idno type="eissn">2058-5276</idno>
                <title level="j">Nature Microbiology</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">9</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">2847-2861</biblScope>
                  <date type="datePub">2024-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41564-024-01832-5</idno>
              <idno type="pubmed">39482383</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Bacteriophages</term>
                <term xml:lang="en">Comparative genomics</term>
                <term xml:lang="en">Phage biology</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Predicting bacteriophage infection of specific bacterial strains promises advancements in phage therapy and microbial ecology. Whether the dynamics of well-established phage-host model systems generalize to the wide diversity of microbes is currently unknown. Here we show that we could accurately predict the outcomes of phage-bacteria interactions at the strain level in natural isolates from the genus Escherichia using only genomic data (area under the receiver operating characteristic curve (AUROC) of 86%). We experimentally established a dataset of interactions between 403 diverse Escherichia strains and 96 phages. Most interactions are explained by adsorption factors as opposed to antiphage systems which play a marginal role. We trained predictive algorithms and pinpoint poorly predicted interactions to direct future research efforts. Finally, we established a pipeline to recommend tailored phage cocktails, demonstrating efficiency on 100 pathogenic E. coli isolates. This work provides quantitative insights into phage-host specificity and supports the use of predictive algorithms in phage therapy.</p>
            </abstract>
            <particDesc>
              <org type="consortium">We thank members of the MDM lab, B. Beamud, D. Bikard, A. Lindner and V. Libis for useful comments on earlier versions of the paper; D. Maura, M. Galtier, M. Henry, N. Dufour, R. Delattre and M. Lourenço from the Bacteriophage, Bacterium, Host lab of Institut Pasteur for the isolation of phages of the Guelin collection; the ColoColi group for sharing the strains of the ColocColi collection; J. Meyer from the Bioinformatic hub of the Institut Pasteur for advice on statistical analysis.</org>
              <org type="consortium">We also thank S. Legout and the team managing scientific archives at the Institut Pasteur for their kind help in naming the phage collection.</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1005021" status="VALID">
          <idno type="IdRef">235514829</idno>
          <idno type="RNSR">201420743R</idno>
          <orgName>Infection, Anti-microbiens, Modélisation, Evolution</orgName>
          <orgName type="acronym">IAME (UMR_S_1137 / U1137)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iame-research.center/</ref>
          </desc>
          <listRelation>
            <relation name="U1137" active="#struct-303623" type="direct"/>
            <relation name="UMR_S_1137" active="#struct-557826" type="direct"/>
            <relation active="#struct-581146" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1090797" status="VALID">
          <idno type="RNSR">202224197K</idno>
          <orgName>Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host</orgName>
          <date type="start">2021-07-21</date>
          <desc>
            <address>
              <addrLine>Département de microbiologie - 25-28 rue du Docteur Roux75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/bacteriophage-bacterium-host/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-557826" type="direct"/>
            <relation active="#struct-1149580" type="direct"/>
            <relation active="#struct-300027" type="indirect"/>
            <relation name="UMR6047" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-344348" status="VALID">
          <idno type="ROR">https://ror.org/004nnf780</idno>
          <orgName>Hôpital Louis Mourier - AP-HP [Colombes]</orgName>
          <desc>
            <address>
              <addrLine>178 Rue des Renouillers, 92700 Colombes</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-148117" status="VALID">
          <idno type="IdRef">139408088</idno>
          <idno type="ROR">https://ror.org/02kbmgc12</idno>
          <orgName>AgroParisTech</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>22 place de l'Agronomie CS 20040 91123 Palaiseau cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.agroparistech.fr/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-1152315" status="VALID">
          <idno type="RNSR">202324353A</idno>
          <orgName>Diversité moléculaire des microbes / Molecular diversity of microbes</orgName>
          <date type="start">2023-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation name="UMR3525" active="#struct-441569" type="direct"/>
            <relation active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-541732" status="OLD">
          <idno type="IdRef">225310155</idno>
          <idno type="ISNI">000000041759735X</idno>
          <idno type="RNSR">199411684F</idno>
          <idno type="ROR">https://ror.org/055ss7a31</idno>
          <orgName>Laboratoire Physico-Chimie Curie [Institut Curie]</orgName>
          <orgName type="acronym">PCC</orgName>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>11 rue Pierre et Marie Curie75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://science.curie.fr/recherche/physique-chimie-biologie-multi-echelle-et-cancer/physico-chimie/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301888" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR168" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300156" status="VALID">
          <idno type="ROR">https://ror.org/03fdnmv92</idno>
          <orgName>AP-HP - Hôpital Bichat - Claude Bernard [Paris]</orgName>
          <desc>
            <address>
              <addrLine>46 Rue Henri Huchard, 75018 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hupnvs.aphp.fr/bichat-claude-bernard/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-581146" status="VALID">
          <idno type="IdRef">02640463X</idno>
          <idno type="ISNI">0000000121496883</idno>
          <idno type="ROR">https://ror.org/0199hds37</idno>
          <orgName>Université Sorbonne Paris Nord</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>99, avenue Jean-Baptiste Clément, 93430 Villetaneuse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1149580" status="VALID">
          <idno type="RNSR">201722310F</idno>
          <orgName>Microbiologie Intégrative et Moléculaire</orgName>
          <orgName type="acronym">UMR6047</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>INSTITUT PASTEUR 25-28 rue du docteur Roux 75015 PARIS - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/integrative-and-molecular-microbiology/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation name="UMR6047" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301888" status="VALID">
          <idno type="ISNI">0000 0004 0639 6384</idno>
          <idno type="ROR">https://ror.org/04t0gwh46</idno>
          <orgName>Institut Curie [Paris]</orgName>
          <desc>
            <address>
              <addrLine>26 rue d'Ulm - 75248 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://science.curie.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-38027" status="VALID">
          <idno type="anr">ANR-11-INBS-0013</idno>
          <idno type="program">Infrastructures</idno>
          <orgName>IFB (ex Renabi-IFB)</orgName>
          <desc>Institut français de bioinformatique</desc>
          <date type="start">2011</date>
        </org>
        <org type="anrProject" xml:id="projanr-51024" status="VALID">
          <idno type="anr">ANR-19-AMRB-0002</idno>
          <orgName>MAPVAP</orgName>
          <desc>Évaluation préclinique et mécanistique de deux cocktails de bactériophages ciblant Pseudomonas aeruginosa et Escherichia coli multirésistants pour le traitement des pneumonies acquises sous ventilation</desc>
          <date type="start">2019</date>
        </org>
        <org type="anrProject" xml:id="projanr-51667" status="VALID">
          <idno type="anr">ANR-20-CE92-0048</idno>
          <orgName>PhaStGut</orgName>
          <desc>Etude des mécanismes de la coexistence stable entre bactériophages et bactéries et de ses conséquences sur la fonction du microbiote intestinal</desc>
          <date type="start">2020</date>
        </org>
        <org type="europeanProject" xml:id="projeurop-736927" status="VALID">
          <idno type="number">101040529</idno>
          <idno type="program">ERC-2021-STG</idno>
          <idno type="call">ERC-2021-STG</idno>
          <orgName>PECAN</orgName>
          <desc>Exploring the Prokaryotic-Eukaryotic Conservation of Antiviral immunity: from bacterial immune systems to novel antiviral drugs</desc>
          <date type="start">2022-10-01</date>
          <date type="end">2027-09-30</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>