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              <p>There are in France several millions of shift-workers and night-workers (20 to 25% of employees). These workers are therefore subject to variations in their working and rest schedules. These regular schedule changes are associated with repeated desynchronization of circadian biological clock. The negative impacts on sleep are insomnia, drowsiness, and reduced sleep time in 24 hours.There is also a proven effect on the occurrence of a metabolic syndrome, with a likely effect on obesity, type 2 diabetes, blood pressure and coronary artery disease. There is a likely effect on the occurrence of cancer (including breast cancer). Night working is not recommended for pregnant women because of the risk of miscarriage, prematurity and intrauterine growth retardation.</p>
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              <p>Plusieurs millions de travailleurs en France travaillent de nuit ou avec des horaires décalés (TPN = 20 à 25 % des salariés) et sont donc soumis régulièrement à des variationsde leurs horaires de travail et de repos. Ce changement régulier des horaires est associé à une désynchronisation répétée de leur horloge biologique circadienne. 192 D. Leger et al.Les répercussions négatives sur le sommeil sont avérées avec insomnie, somnolence, et réduction du temps de sommeil par 24 heures. Il existe un effet avéré du TPN sur la survenue d’un syndrome métabolique, avec un effet probable sur celle d’une obésité, d’un diabète de type 2 et d’une hypertension artérielle et de maladie coronarienne. On retrouve un effet probable du travail de nuit sur la survenue d’un cancer, notamment d’un cancer du sein. Le travail de nuit est non recommandé chez la femme enceinte compte tenu du risque de fausse-couche, prématurité et de retard de croissance intra-utérin.</p>
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