Fast microfluidic osmotic compression with operando meso structure characterisation by SAXS
Résumé
Osmotic compression is used to establish phase diagrams and equations of state (EOS) of colloidal suspensions. It is classically conducted in mL-scale dialysis bags and takes weeks of equilibration. Here we downsized this technique to the nL-scale using new microfluidic chips in which a hydrogel membrane is directly synthesized. The entire meso-structure and EOS of a colloidal dispersion can be measured in a few hours, with precisely controlled pH and chemical potential of ions [1]. The EOS can be determined either by optical microscopy or by analysis of SAXS signals recorded in operando, during compression. The latter option provides additional insight into the meso-structure of the dispersion (glass or crystal phases, etc) and does not require access to a synchrotron source provided suitable chip and laboratory beamline modifications that will be presented are performed [2]. Experimental results confirmed by theory and simulations will be presented for proteins and latex, silica, and gold nanoparticles.
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