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                <title level="j">European Journal of Pain</title>
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                <term xml:lang="en">Fabry disease</term>
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              <p>European Journal of Pain published by John Wiley &amp;amp; Sons Ltd on behalf of European Pain Federation - EFIC ®.Background: Fabry disease (FD) is a rare X-linked lysosomal disorder caused by alpha-galactosidase deficiency consecutive to a pathogenic variant in the GLA gene. Age at onset is highly variable, with a wide clinical spectrum including frequent renal, cardiac, skin and nervous system manifestations. Since pain can be an indicator of underlying FD, we wanted to estimate the prevalence of FD in a population of chronic pain patients. Methods: Two studies, DOUFAB and DOUFABIS, were carried out in expert centers for chronic pain to assess the prevalence of FD by measuring alpha galactosidase A activity in men and analysing the GLA gene in women. Results: Analysis of 893 patients, essentially adults, led to the diagnosis of FD in one female patient, now treated with enzyme replacement therapy. Conclusions: The prevalence of FD is estimated about 1/1000 in our population of men and women suffering from various chronic pain. This is nearly the prevalence of FD observed in other previously screened high-risk populations with renal failure. Significance: Although a systematic search for FD does not seem relevant in the context of unexplained chronic pain in adults, a positive family history of FD or the presence of additional FD related organ features must lead to consider this rare disease diagnosis. Therefore, pain specialists need to be aware of main features of FD, including pain characteristics.</p>
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              <org type="consortium">DOUFABIS Consortium: Myriam Cadenne, Anne-Sophie Blanchet, Sylvie Berciaud, Alexandre Cauchie, Virginie Corand, Laurence David, Nathalie Cantagrel, Stéphanie Ranque-Garnier, Maud Martial, Géraldine De Montgazon, Caroline Maindet-Dominici, Eric Salvat, Elizabeth Sarrazin, Rémi Bellance, Jean-Michel Wattier, Stéphanie Roggerone, Virgine Piano, Jean-Pascal Lefaucheur, Julie Bismuth, Marc Sorel</org>
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