Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review - Archive ouverte HAL
Journal Articles Current Organic Chemistry Year : 2024

Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review

Abstract

Abstract: The most economical and efficient route to prepare polypeptides from synthetic chemistry is through the Ring-opening Polymerization (ROP) of amino acids using Ncarboxyanhydride (NCA) monomers. Peptide polymers, in contrast to proteins, consist of repeated amino acid units and are comparatively simpler macromolecules. Despite their simplicity, these polypeptides offer a unique combination of beneficial traits found in both synthetic polymers (such as solubility, processability, and rubber elasticity) and natural proteins (including secondary structure, functionality, and biocompatibility). Nevertheless, NCA polymerization faces significant challenges, including intricate monomer purification and the necessity for processing toxic solvents. In this context, this review presents the fundamental principles of this polymer chemistry, the synthesis of NCA monomers, and the different methodologies to access polypeptides by ROP. It also explores the most recent advances in this field of research, with a focus on how new methods enable the use of more reactive initiators and the development of original processes, including the use of aqueous solvents.
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Dates and versions

hal-04775415 , version 1 (10-11-2024)

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Mostafa Badreldin, Pedro Salas-Ambrosio, Simon Harrisson, Marcela Ayala, Colin Bonduelle. Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review. Current Organic Chemistry, 2024, 28 (15), pp.1154-1163. ⟨10.2174/0113852728274519240228105518⟩. ⟨hal-04775415⟩

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