Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)
Jean-Pascal Lefaucheur
(1, 2)
,
André Aleman
(3, 4)
,
Chris Baeken
(5, 6, 7)
,
David Benninger
(8)
,
Jérôme Brunelin
(9, 10)
,
Vincenzo Di Lazzaro
(11)
,
Saša Filipović
(12)
,
Christian Grefkes
(13, 14)
,
Alkomiet Hasan
(15)
,
Friedhelm Hummel
(16, 17)
,
Satu Jääskeläinen
(18)
,
Berthold Langguth
(19)
,
Letizia Leocani
(20, 21)
,
Alain Londero
(22, 23, 24)
,
Raffaele Nardone
(25)
,
Jean-Paul Nguyen
(26, 27)
,
Thomas Nyffeler
(28, 29)
,
Albino Oliveira-Maia
(30, 31)
,
Antonio Oliviero
(32)
,
Frank Padberg
(15)
,
Ulrich Palm
(15)
,
Walter Paulus
(33)
,
Emmanuel Poulet
(9, 10, 34)
,
Angelo Quartarone
(35)
,
Fady Rachid
(36)
,
Irena Rektorová
(37, 38)
,
Simone Rossi
(39)
,
Hanna Sahlsten
(18)
,
Martin Schecklmann
(19)
,
David Szekely
(40)
,
Ulf Ziemann
(41, 42)
1
ENT -
Excitabilité nerveuse et thérapeutique
2 Hôpital Henri Mondor
3 University of Groningen [Groningen]
4 UMCG - University Medical Center Groningen [Groningen]
5 UGENT - Universiteit Gent = Ghent University = Université de Gand
6 UZ Brussel - Universitair Ziekenhuis Brussel = University Hospital of Brussels
7 TU/e - Eindhoven University of Technology [Eindhoven]
8 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
9 CRNL-PSYR2 - Psychiatric Disorders, Neuroscience Research and Clinical Research
10 Centre Hospitalier le Vinatier [Bron]
11 UCBM - Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome
12 University of Belgrade [Belgrade]
13 University Hospital of Cologne [Cologne]
14 Jülich Research Centre
15 University Hospital LMU Munich
16 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
17 UNIGE - Université de Genève = University of Geneva
18 University of Turku
19 University of Regensburg
20 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
21 IRCCS Ospedale San Raffaele [Milan, Italy]
22 HEGP - Hôpital Européen Georges Pompidou [APHP]
23 USPC - Université Sorbonne Paris Cité
24 UPD5 - Université Paris Descartes - Paris 5
25 PMU - Paracelsus Medizinische Privatuniversität = Paracelsus Medical University
26 Clinique Bretéché [Nantes]
27 EA 3826 - Thérapeutiques cliniques et expérimentales des infections (EA 3826)
28 UNIBE - Universität Bern = University of Bern = Université de Berne
29 Luzerner Kantonsspital [Lucerne, Switzerland]
30 Centro Hospitalar de Lisboa Ocidental [Lisbonne]
31 NOVA - Universidade Nova de Lisboa = NOVA University Lisbon
32 HNP - Hospital Nacional de Parapléjicos de Toledo
33 UMG - University Medical Center Göttingen
34 Hôpital Edouard Herriot [CHU - HCL]
35 UniMe - Università degli Studi di Messina = University of Messina
36 Sans affiliation
37 MUNI - Masaryk University [Brno]
38 St. Anne’s University Hospital [Brno]
39 UNISI - Università degli Studi di Siena = University of Siena
40 Centre Hospitalier Princesse Grace
41 Eberhard Karls Universität Tübingen = University of Tübingen
42 Hertie Institute for Clinical Brain Research [Tubingen]
2 Hôpital Henri Mondor
3 University of Groningen [Groningen]
4 UMCG - University Medical Center Groningen [Groningen]
5 UGENT - Universiteit Gent = Ghent University = Université de Gand
6 UZ Brussel - Universitair Ziekenhuis Brussel = University Hospital of Brussels
7 TU/e - Eindhoven University of Technology [Eindhoven]
8 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
9 CRNL-PSYR2 - Psychiatric Disorders, Neuroscience Research and Clinical Research
10 Centre Hospitalier le Vinatier [Bron]
11 UCBM - Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome
12 University of Belgrade [Belgrade]
13 University Hospital of Cologne [Cologne]
14 Jülich Research Centre
15 University Hospital LMU Munich
16 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
17 UNIGE - Université de Genève = University of Geneva
18 University of Turku
19 University of Regensburg
20 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
21 IRCCS Ospedale San Raffaele [Milan, Italy]
22 HEGP - Hôpital Européen Georges Pompidou [APHP]
23 USPC - Université Sorbonne Paris Cité
24 UPD5 - Université Paris Descartes - Paris 5
25 PMU - Paracelsus Medizinische Privatuniversität = Paracelsus Medical University
26 Clinique Bretéché [Nantes]
27 EA 3826 - Thérapeutiques cliniques et expérimentales des infections (EA 3826)
28 UNIBE - Universität Bern = University of Bern = Université de Berne
29 Luzerner Kantonsspital [Lucerne, Switzerland]
30 Centro Hospitalar de Lisboa Ocidental [Lisbonne]
31 NOVA - Universidade Nova de Lisboa = NOVA University Lisbon
32 HNP - Hospital Nacional de Parapléjicos de Toledo
33 UMG - University Medical Center Göttingen
34 Hôpital Edouard Herriot [CHU - HCL]
35 UniMe - Università degli Studi di Messina = University of Messina
36 Sans affiliation
37 MUNI - Masaryk University [Brno]
38 St. Anne’s University Hospital [Brno]
39 UNISI - Università degli Studi di Siena = University of Siena
40 Centre Hospitalier Princesse Grace
41 Eberhard Karls Universität Tübingen = University of Tübingen
42 Hertie Institute for Clinical Brain Research [Tubingen]
Jean-Pascal Lefaucheur
- Fonction : Auteur
Jérôme Brunelin
- Fonction : Auteur
- PersonId : 752382
- IdHAL : jbrunelin
- ORCID : 0000-0001-5479-5628
- IdRef : 124622356
Emmanuel Poulet
- Fonction : Auteur
- PersonId : 1233010
- IdHAL : emmanuel-poulet
- ORCID : 0000-0001-5709-9038
- IdRef : 069926352
Résumé
A group of European experts reappraised the guidelines on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) previously published in 2014 [Lefaucheur et al., Clin Neurophysiol 2014;125:2150-206]. These updated recommendations take into account all rTMS publications, including data prior to 2014, as well as currently reviewed literature until the end of 2018. Level A evidence (definite efficacy) was reached for: high-frequency (HF) rTMS of the primary motor cortex (M1) contralateral to the painful side for neuropathic pain; HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC) using a figure-of-8 or a H1-coil for depression; low-frequency (LF) rTMS of contralesional M1 for hand motor recovery in the post-acute stage of stroke. Level B evidence (probable efficacy) was reached for: HF-rTMS of the left M1 or DLPFC for improving quality of life or pain, respectively, in fibromyalgia; HF-rTMS of bilateral M1 regions or the left DLPFC for improving motor impairment or depression, respectively, in Parkinson's disease; HF-rTMS of ipsilesional M1 for promoting motor recovery at the post-acute stage of stroke; intermittent theta burst stimulation targeted to the leg motor cortex for lower limb spasticity in multiple sclerosis; HF-rTMS of the right DLPFC in posttraumatic stress disorder; LF-rTMS of the right inferior frontal gyrus in chronic post-stroke non-fluent aphasia; LF-rTMS of the right DLPFC in depression; and bihemispheric stimulation of the DLPFC combining right-sided LF-rTMS (or continuous theta burst stimulation) and left-sided HF-rTMS (or intermittent theta burst stimulation) in depression. Level A/B evidence is not reached concerning efficacy of rTMS in any other condition. The current recommendations are based on the differences reached in therapeutic efficacy of real vs. sham rTMS protocols, replicated in a sufficient number of independent studies. This does not mean that the benefit produced by rTMS inevitably reaches a level of clinical relevance.