This contribution summarizes the most informative loess–palaeosol sequences (LPS) and fluvial terrace records from the late Middle Pleistocene (LMP) of northern France demonstrating the reliability of the cyclostratigraphic approach for the interpretation of pedosedimentary sequences controlled by major glacial–interglacial climatic cycles. In this area, continental mollusc assemblages from interglacial fluvial silts and calcareous tufas are particularly rich and diverse and marker species define the malacological signatures of each interglacial optimum for Marine Isotope Stages (MIS) 11, 9 and 5e. This approach shows that the forest was less developed during MIS 7, suggesting that climatic conditions were either drier and/or cooler than during other Pleistocene interglacials. In the Somme basin, the terrace system shows that two alluvial formations were deposited between early MIS 8 and late MIS 7. In some LPS, the occurrence of two pedosedimentary sub‐cycles (IIa and IIb), separated by a relatively long (~12 ka) and cold period, corresponding to an ‘aborted glacial’ (MIS 7d), underlines the complex pattern of this unusual ‘interglacial’. Overall, during the LMP, each soil complex corresponding to interglacial and early‐glacial periods from MIS 11 to MIS 5 is broadly made up of the same soil facies but exhibits a specific succession pattern or signature. Throughout the area, LPS show a huge change in both the deposition rates and the geographical extent of typical calcareous loess at the beginning of MIS 6. This so‐called ‘Loess Revolution’ probably reflects a change in the palaeogeography of the southern North Sea and eastern Channel source areas at times marked by the coalescence of the British and Scandinavian ice sheets. MIS 6 is also characterized by the oldest evidence of permafrost development in the area. In addition, this work allows the age of the Lower/Middle Palaeolithic boundary to be confirmed, with the oldest occurrence of Levallois technology being around 300 ka.