<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04762608v1</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T00:57:06+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes</title>
            <author role="aut">
              <persName>
                <forename type="first">Julian</forename>
                <surname>Gurgo</surname>
              </persName>
              <idno type="halauthorid">1324363-0</idno>
              <affiliation ref="#struct-1100674"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Charles</forename>
                <surname>Walter</surname>
              </persName>
              <email type="md5">0ad6278c6415a2ee6062304ba85e34f8</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">jean-charles-walter</idno>
              <idno type="idhal" notation="numeric">738456</idno>
              <idno type="halauthorid" notation="string">34635-738456</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7313-0100</idno>
              <idno type="IDREF">https://www.idref.fr/139250964</idno>
              <affiliation ref="#struct-1100677"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Bernard</forename>
                <surname>Fiche</surname>
              </persName>
              <idno type="halauthorid">418828-0</idno>
              <affiliation ref="#struct-1100674"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Houbron</surname>
              </persName>
              <idno type="halauthorid">220472-0</idno>
              <affiliation ref="#struct-1100674"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Schaeffer</surname>
              </persName>
              <email type="md5">c821bea7724b46ec1e3fc0f5d04ebfff</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">marie-schaeffer</idno>
              <idno type="idhal" notation="numeric">1150542</idno>
              <idno type="halauthorid" notation="string">675813-1150542</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/C-9815-2019</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/C-9815-2019</idno>
              <affiliation ref="#struct-1100674"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Giacomo</forename>
                <surname>Cavalli</surname>
              </persName>
              <email type="md5">9efdd38096ef4e3d0f7def5912a7bc65</email>
              <email type="domain">igh.cnrs.fr</email>
              <idno type="idhal" notation="string">giacomocavalli</idno>
              <idno type="idhal" notation="numeric">8768</idno>
              <idno type="halauthorid" notation="string">48289-8768</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-7958-2008</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3709-3469</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=5oWMD9EAAAAJ&amp;hl=en</idno>
              <idno type="IDREF">https://www.idref.fr/08444441X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-7958-2008</idno>
              <affiliation ref="#struct-1100645"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Frédéric</forename>
                <surname>Bantignies</surname>
              </persName>
              <email type="md5">a6b6c42f377b3baf74ca1109a8ce9caf</email>
              <email type="domain">igh.cnrs.fr</email>
              <idno type="idhal" notation="string">frederic-bantignies</idno>
              <idno type="idhal" notation="numeric">738566</idno>
              <idno type="halauthorid" notation="string">2098302-738566</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4063-7324</idno>
              <idno type="IDREF">https://www.idref.fr/133985903</idno>
              <affiliation ref="#struct-1100645"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Marcelo</forename>
                <surname>Nollmann</surname>
              </persName>
              <email type="md5">abd932e6b3f16fea96699618eeef6faf</email>
              <email type="domain">cbs.cnrs.fr</email>
              <idno type="idhal" notation="string">marcnol</idno>
              <idno type="idhal" notation="numeric">176559</idno>
              <idno type="halauthorid" notation="string">38873-176559</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3339-2349</idno>
              <idno type="IDREF">https://www.idref.fr/164387196</idno>
              <affiliation ref="#struct-1100674"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>L2c</forename>
                <surname>Aigle</surname>
              </persName>
              <email type="md5">896b4172ec7889f15eabdfaa746b8133</email>
              <email type="domain">umontpellier.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-10-26 15:41:17</date>
              <date type="whenWritten">2022-05-30</date>
              <date type="whenModified">2025-03-31 12:50:39</date>
              <date type="whenReleased">2022-10-28 11:17:39</date>
              <date type="whenProduced">2022-05-30</date>
              <date type="whenEndEmbargoed">2022-10-26</date>
              <ref type="file" target="https://hal.science/hal-04762608v1/document">
                <date notBefore="2022-10-26"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04762608v1/file/JULIANetal.pdf" id="file-3830853-3350518">
                <date notBefore="2022-10-26"/>
              </ref>
              <ref type="externalLink" target="https://www.biorxiv.org/content/biorxiv/early/2022/05/16/2022.05.16.492046.full.pdf"/>
            </edition>
            <edition n="v2">
              <date type="whenSubmitted">2024-10-31 17:14:28</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="157154">
                <persName>
                  <forename>L2c</forename>
                  <surname>Aigle</surname>
                </persName>
                <email type="md5">896b4172ec7889f15eabdfaa746b8133</email>
                <email type="domain">umontpellier.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04762608</idno>
            <idno type="halUri">https://hal.science/hal-04762608</idno>
            <idno type="halBibtex">gurgo:hal-04762608</idno>
            <idno type="halRefHtml">2022</idno>
            <idno type="halRef">2022</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3830853-3350518"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt/>
          <notesStmt/>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Julian</forename>
                    <surname>Gurgo</surname>
                  </persName>
                  <idno type="halauthorid">1324363-0</idno>
                  <affiliation ref="#struct-1100674"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Charles</forename>
                    <surname>Walter</surname>
                  </persName>
                  <email type="md5">0ad6278c6415a2ee6062304ba85e34f8</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">jean-charles-walter</idno>
                  <idno type="idhal" notation="numeric">738456</idno>
                  <idno type="halauthorid" notation="string">34635-738456</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7313-0100</idno>
                  <idno type="IDREF">https://www.idref.fr/139250964</idno>
                  <affiliation ref="#struct-1100677"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Bernard</forename>
                    <surname>Fiche</surname>
                  </persName>
                  <idno type="halauthorid">418828-0</idno>
                  <affiliation ref="#struct-1100674"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Houbron</surname>
                  </persName>
                  <idno type="halauthorid">220472-0</idno>
                  <affiliation ref="#struct-1100674"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Schaeffer</surname>
                  </persName>
                  <email type="md5">c821bea7724b46ec1e3fc0f5d04ebfff</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">marie-schaeffer</idno>
                  <idno type="idhal" notation="numeric">1150542</idno>
                  <idno type="halauthorid" notation="string">675813-1150542</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/C-9815-2019</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/C-9815-2019</idno>
                  <affiliation ref="#struct-1100674"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Giacomo</forename>
                    <surname>Cavalli</surname>
                  </persName>
                  <email type="md5">9efdd38096ef4e3d0f7def5912a7bc65</email>
                  <email type="domain">igh.cnrs.fr</email>
                  <idno type="idhal" notation="string">giacomocavalli</idno>
                  <idno type="idhal" notation="numeric">8768</idno>
                  <idno type="halauthorid" notation="string">48289-8768</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-7958-2008</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3709-3469</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=5oWMD9EAAAAJ&amp;hl=en</idno>
                  <idno type="IDREF">https://www.idref.fr/08444441X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-7958-2008</idno>
                  <affiliation ref="#struct-1100645"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Frédéric</forename>
                    <surname>Bantignies</surname>
                  </persName>
                  <email type="md5">a6b6c42f377b3baf74ca1109a8ce9caf</email>
                  <email type="domain">igh.cnrs.fr</email>
                  <idno type="idhal" notation="string">frederic-bantignies</idno>
                  <idno type="idhal" notation="numeric">738566</idno>
                  <idno type="halauthorid" notation="string">2098302-738566</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4063-7324</idno>
                  <idno type="IDREF">https://www.idref.fr/133985903</idno>
                  <affiliation ref="#struct-1100645"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Marcelo</forename>
                    <surname>Nollmann</surname>
                  </persName>
                  <email type="md5">abd932e6b3f16fea96699618eeef6faf</email>
                  <email type="domain">cbs.cnrs.fr</email>
                  <idno type="idhal" notation="string">marcnol</idno>
                  <idno type="idhal" notation="numeric">176559</idno>
                  <idno type="halauthorid" notation="string">38873-176559</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3339-2349</idno>
                  <idno type="IDREF">https://www.idref.fr/164387196</idno>
                  <affiliation ref="#struct-1100674"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">L2C:22-049</idno>
                <imprint/>
              </monogr>
              <idno type="biorxiv">2022.05.16.492046</idno>
              <idno type="doi">10.1101/2022.05.16.492046</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="phys.phys.phys-bio-ph">Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]</classCode>
              <classCode scheme="halTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
              <classCode scheme="halOldTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
              <classCode scheme="halTreeTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Polycomb (Pc) group proteins are transcriptional regulators with key roles in development, cell identity and differentiation. Pc-bound chromatin regions form repressive domains that interact in 3D to assemble repressive nuclear compartments. Here, we used multiplexed chromatin imaging to investigate whether Pc compartments involve the clustering of multiple Pc domains during Drosophila development. Notably, 3D proximity between Pc targets is rare and involves predominantly pairwise interactions. These 3D proximities are particularly enhanced in segments where Pc genes are co-repressed. In addition, segment-specific expression of Hox Pc targets leads to their spatial segregation from Pc repressed genes. Finally, non-Hox Pc targets are proximal in regions where they are co-expressed. These results indicate that long-range Pc interactions are temporally and spatially regulated during differentiation and development but do not involve clustering of multiple distant Pc genes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1100674" status="VALID">
          <idno type="ISNI">0000000406391954</idno>
          <idno type="RNSR">200717455X</idno>
          <idno type="ROR">https://ror.org/0189yvq06</idno>
          <orgName>Centre de Biologie Structurale [Montpellier]</orgName>
          <orgName type="acronym">CBS</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>29 rue de Navacelles 34090 Montpellier Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cbs.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1054" active="#struct-303623" type="direct"/>
            <relation name="UMR5048" active="#struct-441569" type="direct"/>
            <relation active="#struct-1100589" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1100677" status="VALID">
          <idno type="ISNI">0000000446872402</idno>
          <idno type="RNSR">201119402W</idno>
          <idno type="ROR">https://ror.org/02ftce284</idno>
          <orgName>Laboratoire Charles Coulomb</orgName>
          <orgName type="acronym">L2C</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>1 place Eugène Bataillon Université Montpellier 34095 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://coulomb.umontpellier.fr</ref>
          </desc>
          <listRelation>
            <relation name="UMR5221" active="#struct-441569" type="direct"/>
            <relation name="HR10M00506" active="#struct-1100589" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1100645" status="VALID">
          <idno type="ISNI">0000000098865504</idno>
          <idno type="RNSR">201722404H</idno>
          <idno type="ROR">https://ror.org/05ee10k25</idno>
          <orgName>Institut de génétique humaine</orgName>
          <orgName type="acronym">IGH</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igh.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR9002 / UPR1142" active="#struct-441569" type="direct"/>
            <relation active="#struct-1100589" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1100589" status="VALID">
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>