More stringent standards for engines and fuels are progressively implemented as alternatives to reduce on-road vehicle emissions. While electric vehicles appear as a perfect alternative since their engines do not emit pollutants, wear and dust resuspension (W&R) and indirect emissions associated with electricity production remain significant sources of pollution. This work compares well-to-wheel emissions (WTW) and abatement strategies for various types of passenger vehicles in Bogotá and Santiago for different pollutants (CO, PM2.5, SO2, and NOx) and greenhouse gases like CO2 equivalent (CO2-Eq). Results show that WTW baseline emissions are more extensive in Bogotá than in Santiago (i.e., 58 and 30% for PM 2.5 and CO 2 -Eq), mainly due to the higher vehicle activity and older state of Bogotá’s fleet. We also evaluated extreme scenarios to assess the potential of a given vehicle technology or energy source to reduce emissions. We assessed, in particular, the replacement of all current vehicles by (1) conventional technologies with stricter emission standards and (2) battery electric vehicles powered with different energy resources. Our results indicate that replacing the current fleet with modern combus- tion technologies has a lower reduction potential than battery electric vehicles, but these reductions largely depend on the energy mix. Substitution by electric vehicles powered with electricity from renewable energies is the most efficient scenario in both cities. Finally, results also stress the importance of the resuspension of deposited road dust and brake and tire wear emissions in both cities as a crucial source of PM 2.5 , which must be better controlled.