Ant venoms contain vertebrate-selective pain-causing sodium channel toxins - Archive ouverte HAL
Article Dans Une Revue Nature Communications Année : 2023

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

Résumé

Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (NaV) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants.
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hal-04750225 , version 1 (23-10-2024)

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Samuel D Robinson, Jennifer R Deuis, Axel Touchard, Angelo Keramidas, Alexander Mueller, et al.. Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 2023, 14 (1), pp.2977. ⟨10.1038/s41467-023-38839-1⟩. ⟨hal-04750225⟩
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