Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts - Archive ouverte HAL
Article Dans Une Revue Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism Année : 2024

Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts

Résumé

The widespread use of per- and polyfluoroalkyl substances (PFASs), and their resistance to degradation, renders human exposure to them inevitable. PFAS exposure disturbs endocrine function, potentially affecting cognitive development in newborns through thyroid dysfunction during pregnancy. Recent studies reveal varying male and female reproductive toxicity across PFAS classes, with alternative analogs affecting sperm parameters and legacy PFASs correlating with conditions like endometriosis. Metabolically, PFASs exposure is linked to metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and liver toxicity, particularly in early childhood. This review focuses on the endocrine-disrupting impact of PFASs, particularly on fertility, thyroid, and metabolic functions. We highlight the complexity of the PFAS issue, given the large number of molecules and their extremely diverse mixed effects.
Fichier non déposé

Dates et versions

hal-04748588 , version 1 (22-10-2024)

Identifiants

Citer

Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau. Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , 2024, ⟨10.1016/j.tem.2024.07.021⟩. ⟨hal-04748588⟩

Collections

CNRS UP-SCIENCES
11 Consultations
0 Téléchargements

Altmetric

Partager

More