This paper delivered at the SBL explores the phenomenon of harmonization and lexical variations in New Testament quotations of the Septuagint (LXX), focusing on instances in the Gospel of Matthew. By examining key readings from Codex Bezae, a significant 5th-century Greek-Latin manuscript, the study delves into the complexities of how the New Testament text aligns with or diverges from the LXX. Specific attention is given to variant readings in Matthew, particularly where harmonization with the Septuagint is identified. The article also discusses the broader implications of these harmonizations for both New Testament textual criticism and Septuagint studies. By analyzing examples such as Matthew 1:23 and Matthew 2:18, the author sheds light on how these variations reflect deeper interactions between the New Testament text, the LXX, and the Hebrew Masoretic Text (MT), offering insights into the transmission of biblical texts and the challenges of establishing an "original" reading.