The complexity of the list homomorphism problem for signed graphs appears difficult to classify. Existing results focus on special classes of signed graphs, such as trees [4] and reflexive signed graphs [25]. Irreflexive signed graphs are in a certain sense the heart of the problem, as noted by a recent paper of Kim and Siggers. We focus on a special class of irreflexive signed graphs, namely those in which the unicoloured edges form a spanning path or cycle, which we call separable signed graphs. We classify the complexity of list homomorphisms to these separable signed graphs; we believe that these signed graphs will play an important role for the general resolution of the irreflexive case. We also relate our results to a conjecture of Kim and Siggers concerning the special case of semi-balanced irreflexive signed graphs; we have proved the conjecture in another paper, and the present results add structural information to that topic.