Article Dans Une Revue Multidisciplinary Biomechanics Journal Année : 2025

Identification of material properties from impedances in Spinal Cord Stimulation (SCS) using computational models.

Résumé

Spinal Cord Stimulation (SCS) is an effective therapy to manage refractory chronic pain (Duarte et al., 2020). SCS consists in delivering electrical field targeting the dorsal column fibers of the spinal through a lead array implanted in the epidural space. Thereby, the activation of the dorsal column fibers triggers the inhibitory interneurons as described in the Gate Control theory (Melzack & Wall, 1965). Computational modelling represents a promising avenue to better understand the target of the electrical field to the dorsal column fibers of the spinal cord. Previous studies rely on a 2-step simulation. First, the electrical field is computed through the Finite Element Method (FEM) at the spine segment scale, with the quasistatic assumption often made. Then, the result of the first simulation was used in a second simulation at the neuron scale to get insight into the electrophysiological behavior of the neural elements of interest (namely, dorsal columns and dorsal root axons, neurons of the dorsal root ganglion and dorsal horn). A recent systematic review, synthesizing the available models in the literature (Liang et al., 2022), high- lighted controversy about some parameters, such as the dura-mater resistivity (Zander et al., 2020). In our study, we investigated the relationship between impedance measurements (which are routinely obtained in patients with implanted lead array during follow-up visits) and parameters of the finite-element models to validate the simulation.

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Dates et versions

hal-04738009 , version 1 (15-10-2024)
hal-04738009 , version 2 (31-01-2025)

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Tom Le Tutour, Michel Rochette, Karim El Houari, Sophie Collin, Laëtitia Caillé, et al.. Identification of material properties from impedances in Spinal Cord Stimulation (SCS) using computational models.. Multidisciplinary Biomechanics Journal, 2025, 49th congress of the Société de Biomécanique, ⟨10.46298/mbj.14526⟩. ⟨hal-04738009v2⟩
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