Article Dans Une Revue Biochimie Année : 2024

ProteoCure : A European network to fine-tune the proteome

1 IGMM - Institut de Génétique Moléculaire de Montpellier
2 CIPF - Centro de Investigación Príncipe Felipe
3 ISTO - Institut des Sciences de la Terre d'Orléans - UMR7327
4 Milieux Poreux - UMR7327
5 CIC bioGUNE - Center for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne)
6 KIT - Karlsruhe Institute of Technology = Karlsruher Institut für Technologie
7 Jacobs University = Constructor University [Bremen]
8 University of Thessaly [Larissa]
9 OSS - Oncogenesis, Stress, Signaling
10 CRLCC - CRLCC Eugène Marquis
11 University of Liverpool
12 Karolinska Institutet = Karolinska Institute [Stockholm]
13 IMGGE - Institute of Molecular Genetics and Genetic Engineering [Belgrade]
14 Laboratory of Pharmaceutical Chemistry
15 I2BC - Institut de Biologie Intégrative de la Cellule
16 Department of Biology - Institute of Technology
17 CEPR - U 1100 - Centre d’Etude des Pathologies Respiratoires [Tours]
18 Wellcome Trust/Cancer Research UK Gurdon Institute
19 NOVA - Universidade Nova de Lisboa = NOVA University Lisbon
20 Università degli studi di Trieste = University of Trieste
21 Department of Biology, Faculty of Sciences and Science Education
22 Department of Evolutionary and Environmental Biology
23 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
24 IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela
25 CNB-CSIC - Centro Nacional de Biotecnología [Madrid]
26 LCC - Laboratoire de chimie de coordination
27 University of Dundee
28 Faculty of Biology, Technion
29 Institute for Fundamental Biomedical Research [Vari, Greece]
30 Max Planck Institute for Dynamics of Complex Technical Systems
31 LUMC - Leiden University Medical Center [Leiden]

Résumé

Proteins are essential molecular actors in every cellular process. From their synthesis to their degradation, they are subject to continuous quality control mechanisms to ensure that they fulfil cellular needs in proper and timely fashion. Proteostasis is a key process allowing cells or organisms to maintain an appropriate but dynamic equilibrium of their proteome (the ensemble of all their proteins). It relies on multiple mechanisms that together control the level, fate and function of individual proteins, and ensure elimination of abnormal ones. The proteostasis network is essential for development and adaptation to environmental changes or challenges. Its dysfunctions can lead to accumulation of deleterious proteins or, conversely, to excessive degradation of beneficial ones, and are implicated in many diseases such as cancers, neurodegeneration, or developmental and aging disorders. Manipulating this network to control abundance of selected target proteins is therefore a strategy with enormous therapeutic or biotechnological potential. The ProteoCure COST Action gathers more than 350 researchers and their teams (31 countries represented) from the academic, clinical, and industrial sectors, who share the conviction that our understanding of proteostasis is mature enough to develop novel and highly specific therapies based on selective tuning of protein levels. Towards this objective, the Action organizes community-building activities to foster synergies among its participants and reinforce training of the next generation of European researchers. Its ambition is to function as a knowledge-based network and a creative exchange hub on normal and pathologic proteostasis, focusing on developing innovative tools modulating the level of specific protein(s).

Fichier principal
Vignette du fichier
Coux, ProteoCure-A European network, 2024.pdf (1.74 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04737518 , version 1 (15-10-2024)

Licence

Identifiants

Citer

Olivier Coux, Rosa Farràs, Abbas Mohamad, Barrio Rosa, Blattner Christine, et al.. ProteoCure : A European network to fine-tune the proteome. Biochimie, 2024, 226, pp.4-9. ⟨10.1016/j.biochi.2024.06.004⟩. ⟨hal-04737518⟩
414 Consultations
192 Téléchargements

Altmetric

Partager

  • More