Semi-Supervised Segmentation with Topological Penalization for Quantifying Retinal Degeneration in Histological Sections
Résumé
Retinal degeneration is a hallmark of various degenerative ocular diseases, and its accurate quantification is crucial for nonclinical pharmacological studies. Here, we describe a method to assess retinal atrophy by measuring the layers' thickness in histological sections stained with hematoxylin and eosin. We use a semi-supervised approach with topological penalization to segment layers followed by thickness measurements along the layers' medial axes. The method is tested on mice for four layers, obtaining a high correlation with manual measurements collected by biologists.
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