Modulatory effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity following cervical spinal cord contusion in the rat - Archive ouverte HAL
Article Dans Une Revue Spine Journal Année : 2024

Modulatory effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity following cervical spinal cord contusion in the rat

Résumé

Background CONTEXT: Magnetic stimulation can noninvasively modulate the neuronal excitability through different stimulatory patterns. Purpose: The present study hypothesized that trans-spinal magnetic stimulation with intermittent theta burst stimulatory pattern can modulate respiratory motor outputs in a pre-clinical rat model of cervical spinal cord injury. Study design: In vivo animal study. Methods: The effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity was assessed in adult rats with unilateral cervical spinal cord contusion at 2 weeks postinjury. Results: The results demonstrated that unilateral cervical spinal cord contusion significantly attenuated the inspiratory activity and motor evoked potential of the diaphragm. Trans-spinal magnetic intermittent theta burst stimulation significantly increased the inspiratory activity of the diaphragm in cervical spinal cord contused rats. Inspiratory bursting was also recruited by trans-spinal magnetic intermittent theta burst stimulation in the rats without diaphragmatic activity after cervical spinal cord injury. In addition, trans-spinal magnetic intermittent theta burst stimulation is associated with increases in oxygen consumption and carbon dioxide production. Conclusions: These results suggest that trans-spinal magnetic intermittent theta burst stimulation can induce respiratory neuroplasticity. Clinical significance: We propose that trans-spinal theta burst magnetic stimulation may be considered a potential rehabilitative strategy for improving the respiratory activity after cervical spinal cord injury. This will require future clinical study.
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hal-04728550 , version 1 (09-10-2024)

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Kun Ze Lee, Stéphane Vinit. Modulatory effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity following cervical spinal cord contusion in the rat. Spine Journal, 2024, 24 (2), pp.352-372. ⟨10.1016/j.spinee.2023.09.013⟩. ⟨hal-04728550⟩
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